CRCGN008_HEPG2_24H:L08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetamide 20.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

163 genes differentially expressed following the CRCGN008_HEPG2_24H:L08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 9.21905
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 8.59615
SNAP25 synaptosomal-associated protein, 25kDa 8.12425
CYCS cytochrome c, somatic 6.274
PLSCR1 phospholipid scramblase 1 5.6906
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 5.49425
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.2863
MINDY1 MINDY lysine 48 deubiquitinase 1 5.0879
FOS FBJ murine osteosarcoma viral oncogene homolog 4.68485
MSRA methionine sulfoxide reductase A 4.67545
DYNLT3 dynein, light chain, Tctex-type 3 4.6126
E2F2 E2F transcription factor 2 4.5446
ANO1 anoctamin 1, calcium activated chloride channel 4.3255
CCDC92 coiled-coil domain containing 92 4.12885
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.1272
EGF epidermal growth factor 3.81305
LOC122526780 uncharacterized LOC122526780 3.7327
RRAGA Ras-related GTP binding A 3.70555
MICALL1 MICAL-like 1 3.56958
TBXA2R thromboxane A2 receptor 3.07761
EVL Enah/Vasp-like 3.0086
GPATCH8 G patch domain containing 8 2.89403
CHEK2 checkpoint kinase 2 2.84993
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.78685
CRTC3 CREB regulated transcription coactivator 3 2.7221
CKAP5 cytoskeleton associated protein 5 2.7001
CCNF cyclin F 2.68672
FXYD1 FXYD domain containing ion transport regulator 1 2.52735
NCAPH non-SMC condensin I complex, subunit H 2.4941
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.4882
BPHL biphenyl hydrolase-like (serine hydrolase) 2.4344
NKX2-5 NK2 homeobox 5 2.4198
STXBP2 syntaxin binding protein 2 2.33425
PRODH2 proline dehydrogenase (oxidase) 2 2.32265
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.29955
FABP3 fatty acid binding protein 3, muscle and heart 2.2968
CREG1 cellular repressor of E1A-stimulated genes 1 2.2739
KIAA0513 KIAA0513 2.2455
EXO1 exonuclease 1 2.23345
FBRS fibrosin 2.22905
MAOA monoamine oxidase A 2.20765
PVALB parvalbumin 2.1923
GNG5 guanine nucleotide binding protein (G protein), gamma 5 2.19
CENPA centromere protein A 2.18465
MMP2 matrix metallopeptidase 2 2.1542
TPPP3 tubulin polymerization-promoting protein family member 3 2.1405
COX17 COX17 cytochrome c oxidase copper chaperone 2.12495
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.11835
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 2.1182
MAP7 microtubule-associated protein 7 2.1134
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 2.11095
MMP1 matrix metallopeptidase 1 2.10378
TDP1 tyrosyl-DNA phosphodiesterase 1 2.0873
SKA1 spindle and kinetochore associated complex subunit 1 2.072
RHBG Rh family, B glycoprotein (gene/pseudogene) 2.0692
TXNL4B thioredoxin-like 4B 2.05955
SPAG5 sperm associated antigen 5 2.0573
LMTK1 lemur tail kinase 1 2.0526
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.05165
VSNL1 visinin-like 1 2.03767
RUNDC3A RUN domain containing 3A 2.03175
AXIN1 axin 1 2.0274
ARRB2 arrestin, beta 2 2.0163
CCNL1 cyclin L1 2.0076

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -8.71185
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.59135
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.44895
DSG2 desmoglein 2 -5.1686
MRPS2 mitochondrial ribosomal protein S2 -4.9813
CD320 CD320 molecule -4.85565
PCNA proliferating cell nuclear antigen -4.50795
CDC20 cell division cycle 20 -4.3123
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -4.17845
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -3.93245
NVL nuclear VCP-like -3.78675
PCCB propionyl CoA carboxylase, beta polypeptide -3.62
PRPF4 pre-mRNA processing factor 4 -3.41162
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.14427
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.98265
TM9SF2 transmembrane 9 superfamily member 2 -2.94415
ZNF304 zinc finger protein 304 -2.7512
BARD1 BRCA1 associated RING domain 1 -2.7207
ZNF606 zinc finger protein 606 -2.71345
BCL7B B-cell CLL/lymphoma 7B -2.68535
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 -2.6717
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.64087
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -2.6365
UFSP2 UFM1-specific peptidase 2 -2.5873
ITGB1BP1 integrin beta 1 binding protein 1 -2.55632
ZNF134 zinc finger protein 134 -2.55385
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -2.51542
SNX11 sorting nexin 11 -2.49635
DRD1 dopamine receptor D1 -2.4765
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.46095
TM9SF3 transmembrane 9 superfamily member 3 -2.45925
WASHC4 WASH complex subunit 4 -2.45398
ZNF544 zinc finger protein 544 -2.4375
RXRA retinoid X receptor, alpha -2.42063
ZNF345 zinc finger protein 345 -2.39775
ZNF253 zinc finger protein 253 -2.34915
ZNF329 zinc finger protein 329 -2.3436
NOX4 NADPH oxidase 4 -2.3365
ZNF135 zinc finger protein 135 -2.33385
DCAF13 DDB1 and CUL4 associated factor 13 -2.28605
ZNF415 zinc finger protein 415 -2.2827
TGDS TDP-glucose 4,6-dehydratase -2.2789
DGKB diacylglycerol kinase, beta 90kDa -2.26565
VNN2 vanin 2 -2.26495
ATP7A ATPase, Cu++ transporting, alpha polypeptide -2.26437
ZNF701 zinc finger protein 701 -2.2396
ZNF208 zinc finger protein 208 -2.23905
ZNF132 zinc finger protein 132 -2.2335
ANAPC2 anaphase promoting complex subunit 2 -2.2232
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough -2.22015
SCAI suppressor of cancer cell invasion -2.21925
ZNF257 zinc finger protein 257 -2.21775
GPR39 G protein-coupled receptor 39 -2.2129
CNOT7 CCR4-NOT transcription complex, subunit 7 -2.20995
HLA-C major histocompatibility complex, class I, C -2.19485
ZNF551 zinc finger protein 551 -2.19145
MCM3 minichromosome maintenance complex component 3 -2.1912
XAB2 XPA binding protein 2 -2.182
POMT1 protein-O-mannosyltransferase 1 -2.17245
ZNF85 zinc finger protein 85 -2.16655
SECISBP2 SECIS binding protein 2 -2.16165
ZNF613 zinc finger protein 613 -2.15405
PMVK phosphomevalonate kinase -2.15225
BEAN1 brain expressed, associated with NEDD4, 1 -2.14255
ZNF587B zinc finger protein 587B -2.13625
CCDC186 coiled-coil domain containing 186 -2.1296
ZNF419 zinc finger protein 419 -2.12015
UCMA upper zone of growth plate and cartilage matrix associated -2.12
ZNF813 zinc finger protein 813 -2.1102
ZNF665 zinc finger protein 665 -2.10975
ZNF667 zinc finger protein 667 -2.1071
ZNF43 zinc finger protein 43 -2.10702
RAB14 RAB14, member RAS oncogene family -2.10577
PDGFC platelet derived growth factor C -2.0974
MCM6 minichromosome maintenance complex component 6 -2.09205
BMP8B bone morphogenetic protein 8b -2.0899
ZNF91 zinc finger protein 91 -2.0767
ZNF223 zinc finger protein 223 -2.07645
PRR14L proline rich 14-like -2.07335
TXNDC9 thioredoxin domain containing 9 -2.0701
ZNF350 zinc finger protein 350 -2.06695
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 -2.06285
ZNF749 zinc finger protein 749 -2.05875
SUSD5 sushi domain containing 5 -2.05615
WBP1L WW domain binding protein 1-like -2.05405
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -2.0482
PAK1IP1 PAK1 interacting protein 1 -2.0455
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.0441
MRTFB myocardin related transcription factor B -2.03
RBM15B RNA binding motif protein 15B -2.02555
TSPY2 testis specific protein, Y-linked 2 -2.0246
RBM34 RNA binding motif protein 34 -2.0216
PTK7 protein tyrosine kinase 7 (inactive) -2.021
TMPRSS3 transmembrane protease, serine 3 -2.02035
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -2.0199
ZNF154 zinc finger protein 154 -2.0148
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -2.01165
H1-1 H1.1 linker histone, cluster member -2.0051
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.00288