CRCGN008_HEPG2_24H:L19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description succinic anhydride 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN008_HEPG2_24H:L19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHN1 chimerin 1 7.0239
GPATCH8 G patch domain containing 8 5.71815
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 5.2309
EGF epidermal growth factor 5.01355
VAV3 vav 3 guanine nucleotide exchange factor 4.09228
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.9272
PLSCR3 phospholipid scramblase 3 3.62217
LCN2 lipocalin 2 3.56785
PRR15L proline rich 15-like 3.24655
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.0271
HSPA1A heat shock 70kDa protein 1A 2.8651
TBP TATA box binding protein 2.83505
ARID5B AT rich interactive domain 5B (MRF1-like) 2.7716
ZNF589 zinc finger protein 589 2.74875
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.6346
TP53BP2 tumor protein p53 binding protein 2 2.5808
FOS FBJ murine osteosarcoma viral oncogene homolog 2.5801
MMP1 matrix metallopeptidase 1 2.57422
CYCS cytochrome c, somatic 2.56875
FBN1 fibrillin 1 2.37322
GLT8D2 glycosyltransferase 8 domain containing 2 2.32305
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.30965
MDFIC MyoD family inhibitor domain containing 2.192
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.17325
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 2.12565
STAT5A signal transducer and activator of transcription 5A 2.0729
HIP1 huntingtin interacting protein 1 2.0621
NCAPD3 non-SMC condensin II complex, subunit D3 2.05285
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.0423
TLR4 toll-like receptor 4 2.0368
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 2.0305
SOCS2 suppressor of cytokine signaling 2 2.0165
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.01325

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.71165
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -5.5338
GOLT1B golgi transport 1B -5.3685
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.31975
C2CD5 C2 calcium-dependent domain containing 5 -4.5892
FGFR4 fibroblast growth factor receptor 4 -4.4823
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.3895
SLC35F2 solute carrier family 35, member F2 -4.36495
GNAS GNAS complex locus -3.51569
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.1807
NRIP1 nuclear receptor interacting protein 1 -2.99775
CCNB1 cyclin B1 -2.9439
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.9062
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.8486
ETNK1 ethanolamine kinase 1 -2.71252
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.69798
RNF167 ring finger protein 167 -2.67725
OXA1L oxidase (cytochrome c) assembly 1-like -2.55785
IFI30 interferon, gamma-inducible protein 30 -2.5539
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.4765
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide -2.47215
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -2.4258
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 -2.3638
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.31815
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -2.306
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 -2.2749
SYNPO2L synaptopodin 2-like -2.27365
CLSTN2 calsyntenin 2 -2.26795
LECT2 leukocyte cell-derived chemotaxin 2 -2.2063
BAALC brain and acute leukemia, cytoplasmic -2.20275
SRSF4 serine/arginine-rich splicing factor 4 -2.1704
ERGIC2 ERGIC and golgi 2 -2.1671
WBP11 WW domain binding protein 11 -2.07702
RBM34 RNA binding motif protein 34 -2.069
ZNF500 zinc finger protein 500 -2.0503
FAM110A family with sequence similarity 110, member A -2.0501
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 -2.0406
CASQ2 calsequestrin 2 (cardiac muscle) -2.035
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -2.02523
INTS13 integrator complex subunit 13 -2.0176
FUZ fuzzy planar cell polarity protein -2.0072
ENO3 enolase 3 (beta, muscle) -2.0058
PDIA3 protein disulfide isomerase family A, member 3 -2.0041
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.00205