CRCGN008_HEPG2_24H:L20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description succinic anhydride 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

87 genes differentially expressed following the CRCGN008_HEPG2_24H:L20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 10.0
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.44215
STK10 serine/threonine kinase 10 5.63153
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.43225
MYLK myosin light chain kinase 4.86915
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.77895
EPN2 epsin 2 4.75873
SNAP25 synaptosomal-associated protein, 25kDa 4.75727
NOTCH1 notch 1 4.734
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.8151
CYCS cytochrome c, somatic 3.552
GTPBP8 GTP-binding protein 8 (putative) 3.4734
TIAM1 T-cell lymphoma invasion and metastasis 1 3.33938
PFKL phosphofructokinase, liver 3.21825
CEMIP2 cell migration inducing hyaluronidase 2 3.2047
UBE2A ubiquitin-conjugating enzyme E2A 3.2034
MINDY1 MINDY lysine 48 deubiquitinase 1 3.14895
HEBP1 heme binding protein 1 3.0844
LPAR2 lysophosphatidic acid receptor 2 3.07665
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.9996
SH3D19 SH3 domain containing 19 2.77815
HLA-DRA major histocompatibility complex, class II, DR alpha 2.774
PIH1D1 PIH1 domain containing 1 2.4419
EHD3 EH-domain containing 3 2.418
PTPRK protein tyrosine phosphatase, receptor type, K 2.40015
FOS FBJ murine osteosarcoma viral oncogene homolog 2.3499
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.33604
CGRRF1 cell growth regulator with ring finger domain 1 2.3013
OSTF1 osteoclast stimulating factor 1 2.29875
LYN LYN proto-oncogene, Src family tyrosine kinase 2.23932
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.23455
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 2.20557
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 2.20135
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.2004
SEC61G Sec61 gamma subunit 2.19875
SOX13 SRY (sex determining region Y)-box 13 2.17908
IGFBP4 insulin-like growth factor binding protein 4 2.1726
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.15265
WDTC1 WD and tetratricopeptide repeats 1 2.11945
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.106
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.07174
AATF apoptosis antagonizing transcription factor 2.0436
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.0348
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.0342
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 2.02955
CALB1 calbindin 1, 28kDa 2.0181

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.7359
TLCD3A TLC domain containing 3A -5.45555
CD320 CD320 molecule -5.21235
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.0853
LDHD lactate dehydrogenase D -4.91915
SLC35F2 solute carrier family 35, member F2 -4.78355
GNAS GNAS complex locus -4.191
TXNRD1 thioredoxin reductase 1 -3.49245
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.3917
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.2437
CCNB2 cyclin B2 -3.14565
RGS2 regulator of G-protein signaling 2 -3.1237
RNF167 ring finger protein 167 -2.91635
NRIP1 nuclear receptor interacting protein 1 -2.86845
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.80905
ITGB1BP1 integrin beta 1 binding protein 1 -2.5924
PECR peroxisomal trans-2-enoyl-CoA reductase -2.5268
TBX2 T-box 2 -2.46978
BBS1 Bardet-Biedl syndrome 1 -2.4343
AURKB aurora kinase B -2.35965
MMP13 matrix metallopeptidase 13 -2.35575
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.3105
CAB39 calcium binding protein 39 -2.2993
NPY neuropeptide Y -2.2589
RBM41 RNA binding motif protein 41 -2.25095
VKORC1 vitamin K epoxide reductase complex, subunit 1 -2.2398
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.20943
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.2037
TEX261 testis expressed 261 -2.20165
ITPKA inositol-trisphosphate 3-kinase A -2.17595
MPV17 MpV17 mitochondrial inner membrane protein -2.1368
SPG11 spastic paraplegia 11 (autosomal recessive) -2.11755
SCMH1 sex comb on midleg homolog 1 (Drosophila) -2.11115
LOXL1 lysyl oxidase-like 1 -2.09335
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.0796
PUM1 pumilio RNA-binding family member 1 -2.07585
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) -2.0752
FUCA1 fucosidase, alpha-L- 1, tissue -2.05065
TCTN1 tectonic family member 1 -2.04735
ALG9 ALG9, alpha-1,2-mannosyltransferase -2.03045
TOMM70 translocase of outer mitochondrial membrane 70 -2.00635