| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | succinic anhydride 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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250 genes differentially expressed following the CRCGN008_HEPG2_24H:L21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 5.2018 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 4.95295 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.81325 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.65285 |
| PIH1D1 | PIH1 domain containing 1 | 4.5584 |
| TBPL1 | TBP-like 1 | 4.51785 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 4.2864 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 4.22303 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.91338 |
| CYCS | cytochrome c, somatic | 3.75495 |
| TBP | TATA box binding protein | 3.1777 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 3.12245 |
| CHN1 | chimerin 1 | 3.1139 |
| MAP7 | microtubule-associated protein 7 | 3.09065 |
| SLCO4C1 | solute carrier organic anion transporter family, member 4C1 | 2.90145 |
| RAB36 | RAB36, member RAS oncogene family | 2.8116 |
| CCDC85B | coiled-coil domain containing 85B | 2.80095 |
| CST4 | cystatin S | 2.7758 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 2.7737 |
| ZNF267 | zinc finger protein 267 | 2.77045 |
| WDTC1 | WD and tetratricopeptide repeats 1 | 2.74018 |
| EZR | ezrin | 2.70222 |
| MB | myoglobin | 2.67865 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.67575 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 2.66182 |
| VPS52 | vacuolar protein sorting 52 homolog (S. cerevisiae) | 2.6547 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 2.6249 |
| NAGK | N-acetylglucosamine kinase | 2.61945 |
| SLC17A3 | solute carrier family 17 (organic anion transporter), member 3 | 2.612 |
| CPT1B | carnitine palmitoyltransferase 1B (muscle) | 2.58833 |
| KRT23 | keratin 23, type I | 2.5512 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.52067 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 2.51675 |
| TCF20 | transcription factor 20 (AR1) | 2.5155 |
| RNF4 | ring finger protein 4 | 2.51305 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 2.50895 |
| TMEM176B | transmembrane protein 176B | 2.5052 |
| SDC4 | syndecan 4 | 2.4612 |
| VCPKMT | valosin containing protein lysine (K) methyltransferase | 2.461 |
| SPI1 | Spi-1 proto-oncogene | 2.43525 |
| PDZK1 | PDZ domain containing 1 | 2.40315 |
| TMEM176A | transmembrane protein 176A | 2.3885 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 2.3805 |
| IMPACT | impact RWD domain protein | 2.3756 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 2.3628 |
| DCTN4 | dynactin 4 (p62) | 2.3562 |
| FIG4 | FIG4 phosphoinositide 5-phosphatase | 2.35195 |
| NR1H4 | nuclear receptor subfamily 1, group H, member 4 | 2.3455 |
| NTS | neurotensin | 2.34475 |
| RTN2 | reticulon 2 | 2.33415 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 2.31275 |
| STATH | statherin | 2.3035 |
| GRAMD1C | GRAM domain containing 1C | 2.3015 |
| REC8 | REC8 meiotic recombination protein | 2.29115 |
| ETNPPL | ethanolamine-phosphate phospho-lyase | 2.28935 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 2.2891 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | 2.276 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | 2.2641 |
| CCL17 | chemokine (C-C motif) ligand 17 | 2.26285 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 2.26065 |
| AP1M2 | adaptor-related protein complex 1, mu 2 subunit | 2.26017 |
| PRPF3 | pre-mRNA processing factor 3 | 2.2596 |
| AHSP | alpha hemoglobin stabilizing protein | 2.25305 |
| AOAH | acyloxyacyl hydrolase (neutrophil) | 2.2421 |
| FCER2 | Fc fragment of IgE, low affinity II, receptor for (CD23) | 2.2367 |
| ALCAM | activated leukocyte cell adhesion molecule | 2.23053 |
| NNMT | nicotinamide N-methyltransferase | 2.21033 |
| ATAD3A | ATPase family, AAA domain containing 3A | 2.207 |
| MFAP2 | microfibrillar-associated protein 2 | 2.19425 |
| EHHADH | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 2.18065 |
| WHR1 | winged helix repair factor 1 | 2.17613 |
| MTCL1 | microtubule crosslinking factor 1 | 2.1753 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.17135 |
| DYNLT1 | dynein, light chain, Tctex-type 1 | 2.15745 |
| SNX7 | sorting nexin 7 | 2.1563 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 2.15485 |
| MYOT | myotilin | 2.1511 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 2.14405 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 2.13925 |
| TRMT1L | tRNA methyltransferase 1 homolog (S. cerevisiae)-like | 2.1351 |
| HSPB8 | heat shock 22kDa protein 8 | 2.13185 |
| CORO1C | coronin, actin binding protein, 1C | 2.1318 |
| DIABLO | diablo, IAP-binding mitochondrial protein | 2.12935 |
| ZNRF2 | zinc and ring finger 2, E3 ubiquitin protein ligase | 2.1252 |
| MTCH1 | mitochondrial carrier 1 | 2.1232 |
| MORN1 | MORN repeat containing 1 | 2.1226 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 2.11115 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 2.1078 |
| ATP5MC1 | ATP synthase membrane subunit c locus 1 | 2.1061 |
| CACNA1F | calcium channel, voltage-dependent, L type, alpha 1F subunit | 2.1032 |
| VRTN | vertebrae development associated | 2.0883 |
| IQCB1 | IQ motif containing B1 | 2.088 |
| TUFT1 | tuftelin 1 | 2.085 |
| MCM9 | minichromosome maintenance complex component 9 | 2.0783 |
| PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | 2.0767 |
| HTN3 | histatin 3 | 2.06985 |
| COXFA4L2 | cytochrome c oxidase hypoxia associated subunit FA4L2 | 2.0695 |
| TBC1D3G | TBC1 domain family member 3G | 2.06455 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 2.0626 |
| CLASRP | CLK4-associating serine/arginine rich protein | 2.0613 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 2.05897 |
| CHSY1 | chondroitin sulfate synthase 1 | 2.05725 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 2.05545 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | 2.0476 |
| SCGN | secretagogin, EF-hand calcium binding protein | 2.0417 |
| OGFRL1 | opioid growth factor receptor-like 1 | 2.04135 |
| SMAP1 | small ArfGAP 1 | 2.03935 |
| SPC25 | SPC25, NDC80 kinetochore complex component | 2.03765 |
| LZTR1 | leucine-zipper-like transcription regulator 1 | 2.0369 |
| ACTA1 | actin, alpha 1, skeletal muscle | 2.0365 |
| DNAH6 | dynein, axonemal, heavy chain 6 | 2.0337 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 | 2.023 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.02253 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 2.02205 |
| GIN1 | gypsy retrotransposon integrase 1 | 2.0197 |
| TCAP | titin-cap | 2.01875 |
| PRR14 | proline rich 14 | 2.01493 |
| CA6 | carbonic anhydrase VI | 2.0134 |
| CKMT1A | creatine kinase, mitochondrial 1A | 2.0129 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | 2.0102 |
| POF1B | premature ovarian failure, 1B | 2.0048 |
| CISH | cytokine inducible SH2-containing protein | 2.00455 |
| C1QB | complement component 1, q subcomponent, B chain | 2.00375 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD320 | CD320 molecule | -10.0 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -10.0 |
| CCNB2 | cyclin B2 | -8.4681 |
| GNAS | GNAS complex locus | -7.65872 |
| ADI1 | acireductone dioxygenase 1 | -5.3676 |
| THAP11 | THAP domain containing 11 | -5.12135 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -5.10075 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -5.07872 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -4.97825 |
| NRIP1 | nuclear receptor interacting protein 1 | -4.73245 |
| MRPS16 | mitochondrial ribosomal protein S16 | -4.69065 |
| COG7 | component of oligomeric golgi complex 7 | -4.66275 |
| ANKRD10 | ankyrin repeat domain 10 | -4.61085 |
| SLC35F2 | solute carrier family 35, member F2 | -4.6019 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -4.48225 |
| LDHD | lactate dehydrogenase D | -4.46915 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -4.31122 |
| RPS5 | ribosomal protein S5 | -4.02665 |
| RPLP2 | ribosomal protein, large, P2 | -3.45335 |
| DGAT1 | diacylglycerol O-acyltransferase 1 | -3.35485 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -3.1298 |
| NELFCD | negative elongation factor complex member C/D | -3.091 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.9585 |
| ALG9 | ALG9, alpha-1,2-mannosyltransferase | -2.87055 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -2.7961 |
| ZNF586 | zinc finger protein 586 | -2.7613 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 | -2.75915 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -2.75605 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | -2.74215 |
| UBFD1 | ubiquitin family domain containing 1 | -2.72235 |
| ICAM3 | intercellular adhesion molecule 3 | -2.59655 |
| HSPA8 | heat shock 70kDa protein 8 | -2.59065 |
| RPL27A | ribosomal protein L27a | -2.5864 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -2.58393 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -2.58245 |
| CCNB1 | cyclin B1 | -2.58115 |
| NTAN1 | N-terminal asparagine amidase | -2.54722 |
| S100A4 | S100 calcium binding protein A4 | -2.5227 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -2.52095 |
| B2M | beta-2-microglobulin | -2.49905 |
| EEF1B2 | eukaryotic translation elongation factor 1 beta 2 | -2.4913 |
| RPS11 | ribosomal protein S11 | -2.48665 |
| NR2E1 | nuclear receptor subfamily 2, group E, member 1 | -2.4753 |
| ACTG1 | actin gamma 1 | -2.46174 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | -2.45775 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -2.4565 |
| POTEF | POTE ankyrin domain family, member F | -2.45439 |
| MEPCE | methylphosphate capping enzyme | -2.452 |
| ENTPD5 | ectonucleoside triphosphate diphosphohydrolase 5 | -2.4358 |
| RPL38 | ribosomal protein L38 | -2.4257 |
| ASTE1 | asteroid homolog 1 (Drosophila) | -2.4249 |
| UBC | ubiquitin C | -2.42075 |
| AOC3 | amine oxidase, copper containing 3 | -2.42005 |
| BUD23 | BUD23 rRNA methyltransferase and ribosome maturation factor | -2.4084 |
| RPL19 | ribosomal protein L19 | -2.3973 |
| RPS7 | ribosomal protein S7 | -2.37365 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | -2.3673 |
| FLCN | folliculin | -2.3585 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -2.35045 |
| ALKBH4 | alkB, alkylation repair homolog 4 (E. coli) | -2.33705 |
| CITED1 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 | -2.33415 |
| RPL9 | ribosomal protein L9 | -2.32535 |
| RBBP5 | retinoblastoma binding protein 5 | -2.3253 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | -2.3219 |
| SRPX | sushi-repeat containing protein, X-linked | -2.30995 |
| GPR20 | G protein-coupled receptor 20 | -2.30915 |
| HSPA1B | heat shock 70kDa protein 1B | -2.30767 |
| RPS4X | ribosomal protein S4, X-linked | -2.30645 |
| RPS20 | ribosomal protein S20 | -2.3043 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -2.28655 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | -2.2774 |
| RNF216 | ring finger protein 216 | -2.25805 |
| BEAN1 | brain expressed, associated with NEDD4, 1 | -2.2496 |
| CCNG1 | cyclin G1 | -2.23415 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -2.22915 |
| ITPKA | inositol-trisphosphate 3-kinase A | -2.2173 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | -2.21665 |
| EMC7 | ER membrane protein complex subunit 7 | -2.2162 |
| RPS24 | ribosomal protein S24 | -2.216 |
| LEP | leptin | -2.1823 |
| RPN2 | ribophorin II | -2.1822 |
| NDUFA7 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa | -2.1806 |
| MECOM | MDS1 and EVI1 complex locus | -2.18012 |
| RPL10A | ribosomal protein L10a | -2.17825 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -2.17269 |
| RAG2 | recombination activating gene 2 | -2.16925 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -2.16855 |
| EIF4H | eukaryotic translation initiation factor 4H | -2.16425 |
| RAG1 | recombination activating gene 1 | -2.16345 |
| TUBA1C | tubulin, alpha 1c | -2.15763 |
| TRAPPC12 | trafficking protein particle complex 12 | -2.1546 |
| PAFAH2 | platelet-activating factor acetylhydrolase 2, 40kDa | -2.15427 |
| POLRMT | polymerase (RNA) mitochondrial (DNA directed) | -2.15325 |
| NTNG2 | netrin G2 | -2.14965 |
| TGIF2 | TGFB-induced factor homeobox 2 | -2.1491 |
| IL1RAP | interleukin 1 receptor accessory protein | -2.1406 |
| ZNF556 | zinc finger protein 556 | -2.1392 |
| OXCT1 | 3-oxoacid CoA transferase 1 | -2.13405 |
| E2F5 | E2F transcription factor 5, p130-binding | -2.1336 |
| MAB21L4 | mab-21 like 4 | -2.13255 |
| CHCHD3 | coiled-coil-helix-coiled-coil-helix domain containing 3 | -2.13155 |
| RPL4 | ribosomal protein L4 | -2.13107 |
| POMGNT1 | protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | -2.1305 |
| ZFYVE26 | zinc finger, FYVE domain containing 26 | -2.1211 |
| SEC24C | SEC24 family member C | -2.1124 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -2.11147 |
| SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 | -2.1067 |
| RERGL | RERG/RAS-like | -2.09715 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -2.09315 |
| TCL1A | T-cell leukemia/lymphoma 1A | -2.08168 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -2.07735 |
| ATP6V1H | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H | -2.0773 |
| GTF2F1 | general transcription factor IIF, polypeptide 1, 74kDa | -2.0733 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -2.07315 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -2.0661 |
| CORO2B | coronin, actin binding protein, 2B | -2.0593 |
| SEM1 | SEM1 26S proteasome subunit | -2.05735 |
| MYOC | myocilin, trabecular meshwork inducible glucocorticoid response | -2.0549 |
| AGBL5 | ATP/GTP binding protein-like 5 | -2.0416 |
| PCDH8 | protocadherin 8 | -2.03795 |
| DDHD2 | DDHD domain containing 2 | -2.03485 |
| RPL14 | ribosomal protein L14 | -2.0331 |
| RETREG3 | reticulophagy regulator family member 3 | -2.02725 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -2.02022 |
| AREL1 | apoptosis resistant E3 ubiquitin protein ligase 1 | -2.01785 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | -2.0087 |
| POMZP3 | POM121 and ZP3 fusion | -2.00738 |
