CRCGN008_HEPG2_24H:L22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description succinic anhydride 5.03 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

81 genes differentially expressed following the CRCGN008_HEPG2_24H:L22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BPHL biphenyl hydrolase-like (serine hydrolase) 7.5604
HEBP1 heme binding protein 1 5.47985
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.36855
HLA-DMA major histocompatibility complex, class II, DM alpha 5.1785
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.80295
CBR3 carbonyl reductase 3 4.771
EGF epidermal growth factor 4.40635
SSBP2 single-stranded DNA binding protein 2 4.2833
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.26195
LOC122526780 uncharacterized LOC122526780 4.15065
HLA-DRA major histocompatibility complex, class II, DR alpha 4.12642
TRIM13 tripartite motif containing 13 3.63515
CYB561 cytochrome b561 3.37248
GPER1 G protein-coupled estrogen receptor 1 3.36695
CCDC85B coiled-coil domain containing 85B 3.1325
TBXA2R thromboxane A2 receptor 3.10815
BIRC2 baculoviral IAP repeat containing 2 3.0627
HSPA1A heat shock 70kDa protein 1A 2.9705
GPATCH8 G patch domain containing 8 2.86155
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.8074
TBP TATA box binding protein 2.63525
KIF20A kinesin family member 20A 2.6309
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.5881
FPGS folylpolyglutamate synthase 2.54655
SNRPC small nuclear ribonucleoprotein polypeptide C 2.4975
WDTC1 WD and tetratricopeptide repeats 1 2.48643
FAM234B family with sequence similarity 234 member B 2.48075
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.3966
CCNH cyclin H 2.373
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.28665
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.2816
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 2.28142
BBS10 Bardet-Biedl syndrome 10 2.2419
CYCS cytochrome c, somatic 2.2128
RGS19 regulator of G-protein signaling 19 2.19335
TULP3 tubby like protein 3 2.18747
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.1769
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.1533
IFI44 interferon-induced protein 44 2.1421
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.12045
SCGB2A1 secretoglobin, family 2A, member 1 2.0794
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.0701
ZNF467 zinc finger protein 467 2.06165
FAM200C family with sequence similarity 200 member C 2.056
MRPL49 mitochondrial ribosomal protein L49 2.05275
ANKRD6 ankyrin repeat domain 6 2.0284
WDCP WD repeat and coiled coil containing 2.00195

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -5.6498
MRPS2 mitochondrial ribosomal protein S2 -5.5078
ACOT9 acyl-CoA thioesterase 9 -5.1652
PCNA proliferating cell nuclear antigen -5.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.88505
ISOC1 isochorismatase domain containing 1 -4.864
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.6568
CD320 CD320 molecule -4.4901
TUBB6 tubulin, beta 6 class V -4.30895
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.21435
SLC35F2 solute carrier family 35, member F2 -4.0303
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -3.6459
ANKRD10 ankyrin repeat domain 10 -3.58375
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.37845
OXA1L oxidase (cytochrome c) assembly 1-like -2.85825
FBXL12 F-box and leucine-rich repeat protein 12 -2.84955
CCNB1 cyclin B1 -2.82615
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.72318
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.5509
LGMN legumain -2.5294
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.46675
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.3975
RBM34 RNA binding motif protein 34 -2.32438
PRPF4 pre-mRNA processing factor 4 -2.32148
GAS6 growth arrest-specific 6 -2.3179
FUBP3 far upstream element (FUSE) binding protein 3 -2.30665
CCP110 centriolar coiled coil protein 110kDa -2.27815
SMIM5 small integral membrane protein 5 -2.20547
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -2.1689
SEPTIN8 septin 8 -2.11935
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.1141
PAEP progestagen-associated endometrial protein -2.10815
SLAMF7 SLAM family member 7 -2.07775
MYO1A myosin IA -2.0188