CRCGN008_HEPG2_24H:L23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description succinic anhydride 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

84 genes differentially expressed following the CRCGN008_HEPG2_24H:L23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRR15L proline rich 15-like 8.5993
GSTZ1 glutathione S-transferase zeta 1 6.4702
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.30535
STIMATE STIM activating enhancer 5.53525
E2F2 E2F transcription factor 2 5.1389
RPP38 ribonuclease P/MRP 38kDa subunit 5.0887
MAMLD1 mastermind-like domain containing 1 4.74165
PPARG peroxisome proliferator-activated receptor gamma 4.42565
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.3418
HLA-DRA major histocompatibility complex, class II, DR alpha 4.28622
SSBP2 single-stranded DNA binding protein 2 4.11477
CXCR4 chemokine (C-X-C motif) receptor 4 4.10627
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.08865
CNPY3 canopy FGF signaling regulator 3 4.01935
GPER1 G protein-coupled estrogen receptor 1 3.95428
SNAP25 synaptosomal-associated protein, 25kDa 3.896
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.1891
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.08532
HEBP1 heme binding protein 1 3.0669
JADE2 jade family PHD finger 2 3.00685
TIAM1 T-cell lymphoma invasion and metastasis 1 2.97815
MAST2 microtubule associated serine/threonine kinase 2 2.93952
CRTAP cartilage associated protein 2.9181
GPATCH8 G patch domain containing 8 2.7571
SLC75A1 solute carrier family 75 member 1 2.74935
CCNF cyclin F 2.43265
FSD1 fibronectin type III and SPRY domain containing 1 2.4272
HSPA14 heat shock 70kDa protein 14 2.4144
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.33675
WDTC1 WD and tetratricopeptide repeats 1 2.31962
CST2 cystatin SA 2.2914
VPREB3 pre-B lymphocyte 3 2.2835
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.2774
USP6NL USP6 N-terminal like 2.236
CFHR2 complement factor H-related 2 2.21535
GPR132 G protein-coupled receptor 132 2.1867
VPREB1 pre-B lymphocyte 1 2.18445
TBC1D4 TBC1 domain family, member 4 2.14815
GLRA2 glycine receptor, alpha 2 2.1364
EPHA3 EPH receptor A3 2.10758
NTS neurotensin 2.10465
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.09315
POMT2 protein-O-mannosyltransferase 2 2.0806
FAM50B family with sequence similarity 50, member B 2.07135
TCP11L1 t-complex 11, testis-specific-like 1 2.0624
IL22 interleukin 22 2.05125
CD81 CD81 molecule 2.0476
CDC123 cell division cycle 123 2.04565
FANCC Fanconi anemia, complementation group C 2.0349
HPX hemopexin 2.03067
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.0244

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
GTPBP8 GTP-binding protein 8 (putative) -5.61225
TRIB3 tribbles pseudokinase 3 -5.22635
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.175
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.17445
KDM3A lysine (K)-specific demethylase 3A -5.10985
GDF15 growth differentiation factor 15 -5.0
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -4.726
ZMIZ1 zinc finger, MIZ-type containing 1 -4.6651
SLC35F2 solute carrier family 35, member F2 -4.2151
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.2074
RBM15B RNA binding motif protein 15B -4.1722
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -4.0264
MAPK13 mitogen-activated protein kinase 13 -3.99223
GNAS GNAS complex locus -3.4762
CCNB2 cyclin B2 -3.39385
RGS2 regulator of G-protein signaling 2 -3.3304
ZNF586 zinc finger protein 586 -3.3233
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.1395
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.85703
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.64615
HSPA8 heat shock 70kDa protein 8 -2.63072
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.61112
TXNDC9 thioredoxin domain containing 9 -2.53988
FHL2 four and a half LIM domains 2 -2.5141
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like -2.4419
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.4388
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -2.28735
COPS4 COP9 signalosome subunit 4 -2.1858
CAVIN2 caveolae associated protein 2 -2.17185
SEC61G Sec61 gamma subunit -2.1156
DCTN4 dynactin 4 (p62) -2.0977
PHLDA3 pleckstrin homology-like domain, family A, member 3 -2.01165