CRCGN008_HEPG2_24H:M01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-diaminotoluene 39.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

126 genes differentially expressed following the CRCGN008_HEPG2_24H:M01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 6.27935
E2F2 E2F transcription factor 2 6.156
PPARG peroxisome proliferator-activated receptor gamma 5.4139
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.30115
VAT1 vesicle amine transport 1 5.24825
ADRB2 adrenoceptor beta 2, surface 5.18485
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.9813
ATP11B ATPase, class VI, type 11B 4.9006
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.68295
ABHD6 abhydrolase domain containing 6 4.40367
CARMIL1 capping protein regulator and myosin 1 linker 1 4.35055
CEP57 centrosomal protein 57kDa 4.20377
GPER1 G protein-coupled estrogen receptor 1 4.18808
PEX11A peroxisomal biogenesis factor 11 alpha 4.08165
CCL2 chemokine (C-C motif) ligand 2 4.04265
MICALL1 MICAL-like 1 4.0127
CDC45 cell division cycle 45 4.00775
HEBP1 heme binding protein 1 3.7958
EPN2 epsin 2 3.744
VGLL4 vestigial-like family member 4 3.30728
CHMP6 charged multivesicular body protein 6 3.24835
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 3.18863
CCDC85B coiled-coil domain containing 85B 3.1827
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 3.11435
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.1105
TBC1D31 TBC1 domain family, member 31 3.08485
EGF epidermal growth factor 3.0721
CYB561 cytochrome b561 2.91431
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 2.8997
FSD1 fibronectin type III and SPRY domain containing 1 2.8168
HLA-DRA major histocompatibility complex, class II, DR alpha 2.79785
JADE2 jade family PHD finger 2 2.76857
MYLK myosin light chain kinase 2.72675
HMOX1 heme oxygenase 1 2.6955
TXNRD1 thioredoxin reductase 1 2.68485
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.60695
PLSCR1 phospholipid scramblase 1 2.59223
EPHA3 EPH receptor A3 2.5605
TNIP1 TNFAIP3 interacting protein 1 2.50195
PLS1 plastin 1 2.4886
TBXA2R thromboxane A2 receptor 2.44675
HAND1 heart and neural crest derivatives expressed 1 2.43495
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.424
HOXA6 homeobox A6 2.40625
S100A10 S100 calcium binding protein A10 2.39015
GRAMD4 GRAM domain containing 4 2.377
ANXA7 annexin A7 2.35565
PEX26 peroxisomal biogenesis factor 26 2.35195
CYCS cytochrome c, somatic 2.3054
SCG2 secretogranin II 2.28455
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.26912
CUBN cubilin (intrinsic factor-cobalamin receptor) 2.2678
ECD ecdysoneless homolog (Drosophila) 2.26085
PITX2 paired-like homeodomain 2 2.2556
CBR1 carbonyl reductase 1 2.23715
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.234
CDC25B cell division cycle 25B 2.2185
FAM163A family with sequence similarity 163, member A 2.21255
MAB21L1 mab-21-like 1 (C. elegans) 2.2114
H2AP H2A.P histone 2.19285
ZNF33B zinc finger protein 33B 2.18335
EYA4 EYA transcriptional coactivator and phosphatase 4 2.1672
MAGEA12 melanoma antigen family A12 2.15865
GATA4 GATA binding protein 4 2.15175
MAGEA2B melanoma antigen family A2B 2.14175
CRYL1 crystallin, lambda 1 2.12795
GIPC2 GIPC PDZ domain containing family, member 2 2.11865
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 2.0874
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 2.0753
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 2.07455
BFSP1 beaded filament structural protein 1, filensin 2.06095
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 2.0588
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.05305
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 2.0445
GPA33 glycoprotein A33 (transmembrane) 2.01845
CDHR5 cadherin-related family member 5 2.01067

decreased expression

Symbol Name Standardized Value
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.2323
WASHC4 WASH complex subunit 4 -5.2107
CCNB2 cyclin B2 -4.97585
PLK1 polo-like kinase 1 -4.8169
LDHD lactate dehydrogenase D -4.7335
ILK integrin-linked kinase -4.6544
PCNA proliferating cell nuclear antigen -4.50795
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -4.2185
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.9245
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.6497
UGDH UDP-glucose 6-dehydrogenase -3.6481
ACAA1 acetyl-CoA acyltransferase 1 -3.5148
DDIT4 DNA-damage-inducible transcript 4 -3.11565
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.10675
CEP83 centrosomal protein 83kDa -2.62855
HYOU1 hypoxia up-regulated 1 -2.6139
ANKRD10 ankyrin repeat domain 10 -2.60955
ALDOC aldolase C, fructose-bisphosphate -2.59725
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.59633
CLDN1 claudin 1 -2.5274
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -2.514
FZD7 frizzled class receptor 7 -2.50253
CYB5R2 cytochrome b5 reductase 2 -2.48295
NVL nuclear VCP-like -2.40825
KDM3A lysine (K)-specific demethylase 3A -2.4004
CCP110 centriolar coiled coil protein 110kDa -2.38335
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha -2.37827
ATF5 activating transcription factor 5 -2.34605
NCAPD2 non-SMC condensin I complex, subunit D2 -2.3306
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.30555
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.2198
SPDEF SAM pointed domain containing ETS transcription factor -2.21202
NUP58 nucleoporin 58 -2.2094
INSL4 insulin-like 4 (placenta) -2.19665
RCL1 RNA terminal phosphate cyclase-like 1 -2.1909
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -2.15665
SLC49A3 solute carrier family 49 member 3 -2.147
ZNF12 zinc finger protein 12 -2.12985
NRIP1 nuclear receptor interacting protein 1 -2.12385
GCC2 GRIP and coiled-coil domain containing 2 -2.0878
FJX1 four jointed box 1 (Drosophila) -2.0862
RHOF ras homolog family member F (in filopodia) -2.0648
ZNF26 zinc finger protein 26 -2.05055
ZNF226 zinc finger protein 226 -2.03595
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -2.02915
CD58 CD58 molecule -2.02637
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.02415
SELENOW selenoprotein W -2.0183
TDG thymine-DNA glycosylase -2.013
COL4A5 collagen, type IV, alpha 5 -2.0115