| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2,4-diaminotoluene 9.8 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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113 genes differentially expressed following the CRCGN008_HEPG2_24H:M03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 6.63807 |
| LAGE3 | L antigen family, member 3 | 5.5248 |
| CEP57 | centrosomal protein 57kDa | 5.4454 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 5.3687 |
| E2F2 | E2F transcription factor 2 | 5.23965 |
| MAMLD1 | mastermind-like domain containing 1 | 5.19055 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.7389 |
| ARL4C | ADP-ribosylation factor-like 4C | 4.4933 |
| ZFP36 | ZFP36 ring finger protein | 4.19405 |
| ADAM10 | ADAM metallopeptidase domain 10 | 3.99657 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 3.9862 |
| CYCS | cytochrome c, somatic | 3.66675 |
| NOSIP | nitric oxide synthase interacting protein | 3.6045 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.57515 |
| TBPL1 | TBP-like 1 | 3.41285 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 3.40939 |
| RXYLT1 | ribitol xylosyltransferase 1 | 3.31327 |
| PLSCR1 | phospholipid scramblase 1 | 3.2136 |
| SOCS2 | suppressor of cytokine signaling 2 | 3.1146 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | 3.1109 |
| CHN1 | chimerin 1 | 3.07255 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | 3.0106 |
| CRYZ | crystallin, zeta (quinone reductase) | 2.90225 |
| MED17 | mediator complex subunit 17 | 2.8961 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.89295 |
| ADAT1 | adenosine deaminase, tRNA-specific 1 | 2.78745 |
| BAMBI | BMP and activin membrane-bound inhibitor | 2.71375 |
| TRIM13 | tripartite motif containing 13 | 2.6091 |
| DNASE2 | deoxyribonuclease II, lysosomal | 2.60545 |
| WDTC1 | WD and tetratricopeptide repeats 1 | 2.60365 |
| DROSHA | drosha, ribonuclease type III | 2.49255 |
| SPRR3 | small proline-rich protein 3 | 2.46925 |
| RAB6A | RAB6A, member RAS oncogene family | 2.4395 |
| PPIP5K2 | diphosphoinositol pentakisphosphate kinase 2 | 2.43705 |
| SLC25A32 | solute carrier family 25 (mitochondrial folate carrier), member 32 | 2.3664 |
| KLF2 | Kruppel-like factor 2 | 2.35525 |
| GDI1 | GDP dissociation inhibitor 1 | 2.35475 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.32083 |
| ANKRD49 | ankyrin repeat domain 49 | 2.3107 |
| KCNK2 | potassium channel, two pore domain subfamily K, member 2 | 2.3087 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 2.23062 |
| ARHGEF17 | Rho guanine nucleotide exchange factor (GEF) 17 | 2.22165 |
| DCUN1D1 | DCN1, defective in cullin neddylation 1, domain containing 1 | 2.21855 |
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | 2.18322 |
| NMU | neuromedin U | 2.1744 |
| EMP2 | epithelial membrane protein 2 | 2.1713 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 2.166 |
| XPOT | exportin, tRNA | 2.1389 |
| AXIN1 | axin 1 | 2.1212 |
| CYP2C8 | cytochrome P450, family 2, subfamily C, polypeptide 8 | 2.1175 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 2.11013 |
| ANXA2 | annexin A2 | 2.10442 |
| NAPG | N-ethylmaleimide-sensitive factor attachment protein, gamma | 2.1009 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 2.0842 |
| LOC122526780 | uncharacterized LOC122526780 | 2.0834 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 2.03545 |
| KRT13 | keratin 13, type I | 2.0278 |
| SOD1 | superoxide dismutase 1, soluble | 2.01605 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HMG20B | high mobility group 20B | -6.36522 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -5.77265 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -5.4639 |
| CDC20 | cell division cycle 20 | -5.318 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -5.22315 |
| ZNF586 | zinc finger protein 586 | -5.2104 |
| STK25 | serine/threonine kinase 25 | -5.16055 |
| MRPS2 | mitochondrial ribosomal protein S2 | -5.10305 |
| ISOC1 | isochorismatase domain containing 1 | -5.0833 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.02785 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -5.00965 |
| UGDH | UDP-glucose 6-dehydrogenase | -5.0 |
| PCNA | proliferating cell nuclear antigen | -5.0 |
| LDHD | lactate dehydrogenase D | -4.94555 |
| CHMP4B | charged multivesicular body protein 4B | -4.9258 |
| TLCD3A | TLC domain containing 3A | -4.8667 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -4.85895 |
| COG2 | component of oligomeric golgi complex 2 | -4.5255 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -4.07985 |
| GNAS | GNAS complex locus | -4.0659 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.89635 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -3.89155 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -3.7815 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | -3.07915 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | -2.994 |
| ZW10 | zw10 kinetochore protein | -2.9637 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.89425 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.80538 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -2.6972 |
| P2RX5 | purinergic receptor P2X, ligand gated ion channel, 5 | -2.6731 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | -2.65935 |
| CCP110 | centriolar coiled coil protein 110kDa | -2.65715 |
| NEDD8 | neural precursor cell expressed, developmentally down-regulated 8 | -2.427 |
| HYI | hydroxypyruvate isomerase (putative) | -2.38985 |
| RPP25 | ribonuclease P/MRP 25kDa subunit | -2.38285 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | -2.3469 |
| PLXDC2 | plexin domain containing 2 | -2.34015 |
| STAG3 | stromal antigen 3 | -2.2992 |
| PZP | pregnancy-zone protein | -2.25115 |
| PAIP2B | poly(A) binding protein interacting protein 2B | -2.21605 |
| LDB3 | LIM domain binding 3 | -2.19537 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -2.1873 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -2.1511 |
| SLURP1 | secreted LY6/PLAUR domain containing 1 | -2.14915 |
| KCNK7 | potassium channel, two pore domain subfamily K, member 7 | -2.13805 |
| TMEM80 | transmembrane protein 80 | -2.1176 |
| ALKBH1 | alkB, alkylation repair homolog 1 (E. coli) | -2.0913 |
| MPV17L-BMERB1 | MPV17L-BMERB1 readthrough | -2.07925 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.07643 |
| PLN | phospholamban | -2.06428 |
| YJU2B | YJU2 splicing factor homolog B | -2.0624 |
| CDC42EP2 | CDC42 effector protein (Rho GTPase binding) 2 | -2.06077 |
| CCND2 | cyclin D2 | -2.05423 |
| TFEB | transcription factor EB | -2.0514 |
| SNRPN | small nuclear ribonucleoprotein polypeptide N | -2.00065 |
