CRCGN008_HEPG2_24H:M04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-diaminotoluene 4.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

182 genes differentially expressed following the CRCGN008_HEPG2_24H:M04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 6.12885
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.6695
GPATCH8 G patch domain containing 8 5.24942
ADGRE5 adhesion G protein-coupled receptor E5 4.986
EPHA3 EPH receptor A3 4.84788
LOC122526780 uncharacterized LOC122526780 4.70265
MYLK myosin light chain kinase 4.6898
VAV3 vav 3 guanine nucleotide exchange factor 4.65658
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.5164
RPP38 ribonuclease P/MRP 38kDa subunit 4.39815
MAMLD1 mastermind-like domain containing 1 4.08075
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.79869
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.4682
FAIM Fas apoptotic inhibitory molecule 3.38825
CDCA4 cell division cycle associated 4 3.32765
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.26516
MAP7 microtubule-associated protein 7 3.10987
TIAM1 T-cell lymphoma invasion and metastasis 1 3.08363
S100A5 S100 calcium binding protein A5 3.0425
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 3.03015
BZW2 basic leucine zipper and W2 domains 2 3.0112
CCL24 chemokine (C-C motif) ligand 24 2.9545
BPHL biphenyl hydrolase-like (serine hydrolase) 2.9156
HEBP1 heme binding protein 1 2.8367
CCNA1 cyclin A1 2.75865
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 2.69895
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.64215
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.63875
CDC16 cell division cycle 16 2.58915
CYCS cytochrome c, somatic 2.52595
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.5227
ERC1 ELKS/RAB6-interacting/CAST family member 1 2.48725
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.4795
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1 2.47735
TRAT1 T cell receptor associated transmembrane adaptor 1 2.45805
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.45
MTM1 myotubularin 1 2.43365
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.42885
DOCK5 dedicator of cytokinesis 5 2.42365
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.40808
GRIK4 glutamate receptor, ionotropic, kainate 4 2.40635
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.38687
MED31 mediator complex subunit 31 2.3804
PTPRS protein tyrosine phosphatase, receptor type, S 2.37945
CLDN9 claudin 9 2.3501
ZNF528 zinc finger protein 528 2.34365
CPAP centrosome assembly and centriole elongation protein 2.33245
ACYP1 acylphosphatase 1, erythrocyte (common) type 2.32095
EML2 echinoderm microtubule associated protein like 2 2.31875
FAM90A1 family with sequence similarity 90, member A1 2.3038
NMUR1 neuromedin U receptor 1 2.30305
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.29945
DLK2 delta-like 2 homolog (Drosophila) 2.29605
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 2.2907
FANCC Fanconi anemia, complementation group C 2.29015
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.2886
MAP2K4 mitogen-activated protein kinase kinase 4 2.28277
TMEM160 transmembrane protein 160 2.28175
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.274
NOX1 NADPH oxidase 1 2.27378
EXTL1 exostosin-like glycosyltransferase 1 2.27285
FMOD fibromodulin 2.25345
ONECUT1 one cut homeobox 1 2.2501
AMHR2 anti-Mullerian hormone receptor, type II 2.2442
GEMIN7 gem (nuclear organelle) associated protein 7 2.24085
KSR1 kinase suppressor of ras 1 2.23875
MRNIP MRN complex interacting protein 2.23215
NKX6-1 NK6 homeobox 1 2.2287
SIRT3 sirtuin 3 2.22827
TAAR5 trace amine associated receptor 5 2.22795
COMMD3 COMM domain containing 3 2.21865
VENTX VENT homeobox 2.2083
IL18 interleukin 18 2.2061
CENPO centromere protein O 2.20525
PDIA2 protein disulfide isomerase family A, member 2 2.2046
UPK1A uroplakin 1A 2.20245
ZIC4 Zic family member 4 2.20075
PRDM16 PR domain containing 16 2.19325
DUOX2 dual oxidase 2 2.1926
ALX4 ALX homeobox 4 2.19235
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.19
LGALS4 lectin, galactoside-binding, soluble, 4 2.1882
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.18385
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 2.1816
NGB neuroglobin 2.18075
CCL1 chemokine (C-C motif) ligand 1 2.17825
SH2D3A SH2 domain containing 3A 2.17632
PLA2G2F phospholipase A2, group IIF 2.17545
FAM246A family with sequence similarity 246 member A 2.16625
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 2.1645
GIMAP4 GTPase, IMAP family member 4 2.1588
STMN3 stathmin-like 3 2.15865
EPHA1 EPH receptor A1 2.1491
MAPK3 mitogen-activated protein kinase 3 2.1409
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.1399
LOC124900193 uncharacterized LOC124900193 2.1395
PPIAL4H peptidylprolyl isomerase A like 4H 2.13385
TREX2 three prime repair exonuclease 2 2.1251
RBL1 retinoblastoma-like 1 2.1208
ACVRL1 activin A receptor type II-like 1 2.12065
NEUROG3 neurogenin 3 2.1202
VPS26C VPS26 endosomal protein sorting factor C 2.1199
VAMP8 vesicle-associated membrane protein 8 2.1165
MYBBP1A MYB binding protein (P160) 1a 2.1161
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.11565
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.1136
TYRO3 TYRO3 protein tyrosine kinase 2.11258
TCL1B T-cell leukemia/lymphoma 1B 2.10205
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.10205
CNGB3 cyclic nucleotide gated channel beta 3 2.10025
INCENP inner centromere protein antigens 135/155kDa 2.0963
GINS3 GINS complex subunit 3 (Psf3 homolog) 2.0926
DIPK2B divergent protein kinase domain 2B 2.09085
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.0904
KATNBL1 katanin p80 subunit B-like 1 2.08545
PTCH2 patched 2 2.0837
LTBP4 latent transforming growth factor beta binding protein 4 2.08092
SBNO2 strawberry notch homolog 2 (Drosophila) 2.06682
LIMS2 LIM and senescent cell antigen-like domains 2 2.0667
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 2.06485
NEIL3 nei endonuclease VIII-like 3 (E. coli) 2.0647
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.0556
NOX3 NADPH oxidase 3 2.05305
AQR aquarius intron-binding spliceosomal factor 2.0476
KIF25 kinesin family member 25 2.04367
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 2.04275
GAST gastrin 2.03885
TMOD3 tropomodulin 3 (ubiquitous) 2.0362
PPP1R37 protein phosphatase 1, regulatory subunit 37 2.03122
NKX2-5 NK2 homeobox 5 2.022
CCKAR cholecystokinin A receptor 2.02135
MYL7 myosin, light chain 7, regulatory 2.0209
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 2.0202
ANXA2 annexin A2 2.01937
NCR2 natural cytotoxicity triggering receptor 2 2.01313
FGF8 fibroblast growth factor 8 (androgen-induced) 2.0115
FGF6 fibroblast growth factor 6 2.00705

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
SLC35F2 solute carrier family 35, member F2 -7.8031
MRPS2 mitochondrial ribosomal protein S2 -5.2275
ADI1 acireductone dioxygenase 1 -5.0945
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.92165
LDHD lactate dehydrogenase D -4.7957
CCNB2 cyclin B2 -4.7794
PCNA proliferating cell nuclear antigen -4.77245
CCDC86 coiled-coil domain containing 86 -4.63215
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.55585
ZNF586 zinc finger protein 586 -4.29415
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.26585
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -4.2218
HLA-DMA major histocompatibility complex, class II, DM alpha -4.1028
GNAS GNAS complex locus -4.03938
SPAG4 sperm associated antigen 4 -4.01065
PRPF4 pre-mRNA processing factor 4 -3.5795
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.5604
ZW10 zw10 kinetochore protein -3.34405
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.81375
UTP11 UTP11 small subunit processome component -2.71385
ADRM1 adhesion regulating molecule 1 -2.576
TXNDC9 thioredoxin domain containing 9 -2.48095
GET1 guided entry of tail-anchored proteins factor 1 -2.41835
PMPCA peptidase (mitochondrial processing) alpha -2.38825
OXA1L oxidase (cytochrome c) assembly 1-like -2.36575
SNX11 sorting nexin 11 -2.36347
IST1 increased sodium tolerance 1 homolog (yeast) -2.32825
UBAC1 UBA domain containing 1 -2.32765
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -2.31255
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.2389
NRIP1 nuclear receptor interacting protein 1 -2.23213
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 -2.14815
TMEM185B transmembrane protein 185B -2.13375
ANAPC2 anaphase promoting complex subunit 2 -2.11815
NQO1 NAD(P)H dehydrogenase, quinone 1 -2.1145
PPP6C protein phosphatase 6, catalytic subunit -2.1054
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.08712
NLRP4 NLR family, pyrin domain containing 4 -2.07345
SEC16A SEC16 homolog A (S. cerevisiae) -2.07235
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.04065
RAB1B RAB1B, member RAS oncogene family -2.04025
FOXD1 forkhead box D1 -2.02965
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -2.02755
MEPCE methylphosphate capping enzyme -2.0178