| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2,4-diaminotoluene 1.22 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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124 genes differentially expressed following the CRCGN008_HEPG2_24H:M06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PRR15L | proline rich 15-like | 8.9403 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 6.67172 |
| GAA | glucosidase, alpha; acid | 5.4145 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 5.1183 |
| RPL39L | ribosomal protein L39-like | 4.85095 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.7144 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.71075 |
| NOTCH1 | notch 1 | 4.70525 |
| ATP11B | ATPase, class VI, type 11B | 4.70525 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.4389 |
| E2F2 | E2F transcription factor 2 | 4.4047 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 4.2162 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 3.94986 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 3.9419 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 3.84783 |
| GRB10 | growth factor receptor-bound protein 10 | 3.81542 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.76113 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 3.7277 |
| CHN1 | chimerin 1 | 3.0994 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 3.05625 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 3.01645 |
| NMU | neuromedin U | 2.94495 |
| RPA3 | replication protein A3, 14kDa | 2.85725 |
| ADAT1 | adenosine deaminase, tRNA-specific 1 | 2.7366 |
| SFTPB | surfactant protein B | 2.71823 |
| TBPL1 | TBP-like 1 | 2.5853 |
| TRIM8 | tripartite motif containing 8 | 2.54785 |
| JADE2 | jade family PHD finger 2 | 2.50517 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 2.48525 |
| CLEC4A | C-type lectin domain family 4, member A | 2.48305 |
| LCMT2 | leucine carboxyl methyltransferase 2 | 2.3867 |
| SNX15 | sorting nexin 15 | 2.38235 |
| KRT1 | keratin 1, type II | 2.37955 |
| PLSCR1 | phospholipid scramblase 1 | 2.37707 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 2.3762 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 2.3732 |
| TNIP1 | TNFAIP3 interacting protein 1 | 2.3666 |
| WFDC2 | WAP four-disulfide core domain 2 | 2.26155 |
| GAMT | guanidinoacetate N-methyltransferase | 2.22005 |
| FLVCR2 | feline leukemia virus subgroup C cellular receptor family, member 2 | 2.20435 |
| PARN | poly(A)-specific ribonuclease | 2.19125 |
| ANGPT2 | angiopoietin 2 | 2.19035 |
| VANGL1 | VANGL planar cell polarity protein 1 | 2.1685 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 2.167 |
| BCL6 | B-cell CLL/lymphoma 6 | 2.16333 |
| URGCP | upregulator of cell proliferation | 2.12155 |
| NOD2 | nucleotide-binding oligomerization domain containing 2 | 2.11875 |
| CD34 | CD34 molecule | 2.1141 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.11325 |
| NDUFA10 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa | 2.111 |
| HSPB1 | heat shock 27kDa protein 1 | 2.0848 |
| SHCBP1 | SHC SH2-domain binding protein 1 | 2.0751 |
| PGR | progesterone receptor | 2.06255 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 2.06245 |
| ARHGAP10 | Rho GTPase activating protein 10 | 2.0568 |
| KIFC1 | kinesin family member C1 | 2.04705 |
| THNSL2 | threonine synthase-like 2 (S. cerevisiae) | 2.0305 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 2.0197 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 2.0029 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FGFR4 | fibroblast growth factor receptor 4 | -8.3248 |
| MRPS2 | mitochondrial ribosomal protein S2 | -5.95805 |
| DNM1L | dynamin 1-like | -5.33605 |
| LDHD | lactate dehydrogenase D | -5.25385 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -5.2337 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -5.01353 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -5.0 |
| CDC20 | cell division cycle 20 | -5.0 |
| CD320 | CD320 molecule | -4.98315 |
| PCNA | proliferating cell nuclear antigen | -4.81965 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -4.78295 |
| CCNB2 | cyclin B2 | -4.6831 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -4.6647 |
| ZNF586 | zinc finger protein 586 | -4.64275 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -4.19475 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -3.825 |
| SPAG4 | sperm associated antigen 4 | -3.6708 |
| LGMN | legumain | -3.64175 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | -3.63255 |
| PAEP | progestagen-associated endometrial protein | -3.42085 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | -3.2182 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | -3.1819 |
| KLRC4-KLRK1 | KLRC4-KLRK1 readthrough | -2.8921 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -2.8799 |
| KLRG1 | killer cell lectin-like receptor subfamily G, member 1 | -2.74835 |
| WASHC4 | WASH complex subunit 4 | -2.62058 |
| TXNDC5 | thioredoxin domain containing 5 (endoplasmic reticulum) | -2.6199 |
| SNX11 | sorting nexin 11 | -2.55928 |
| ADRM1 | adhesion regulating molecule 1 | -2.5442 |
| TENT4A | terminal nucleotidyltransferase 4A | -2.5442 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | -2.51165 |
| RAI14 | retinoic acid induced 14 | -2.5116 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.45923 |
| S1PR5 | sphingosine-1-phosphate receptor 5 | -2.4521 |
| TCF21 | transcription factor 21 | -2.44945 |
| KLF1 | Kruppel-like factor 1 (erythroid) | -2.41905 |
| CCL5 | chemokine (C-C motif) ligand 5 | -2.3682 |
| DMAP1 | DNA methyltransferase 1 associated protein 1 | -2.32775 |
| CTSW | cathepsin W | -2.299 |
| KLRF1 | killer cell lectin-like receptor subfamily F, member 1 | -2.2471 |
| NVL | nuclear VCP-like | -2.2418 |
| GZMK | granzyme K (granzyme 3; tryptase II) | -2.2412 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -2.2408 |
| RGS2 | regulator of G-protein signaling 2 | -2.2272 |
| CDC25B | cell division cycle 25B | -2.2257 |
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | -2.22095 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.2135 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -2.20935 |
| SMIM29 | small integral membrane protein 29 | -2.20065 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -2.1599 |
| PRR5 | proline rich 5 (renal) | -2.15015 |
| SH2D2A | SH2 domain containing 2A | -2.13295 |
| CSRP1 | cysteine and glycine-rich protein 1 | -2.12097 |
| TCIM | transcriptional and immune response regulator | -2.088 |
| UCKL1 | uridine-cytidine kinase 1-like 1 | -2.0814 |
| RFPL2 | ret finger protein-like 2 | -2.07915 |
| CCDC57 | coiled-coil domain containing 57 | -2.0745 |
| NKG7 | natural killer cell granule protein 7 | -2.0742 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -2.05812 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | -2.0542 |
| CD46 | CD46 molecule, complement regulatory protein | -2.03623 |
| BTG2 | BTG family, member 2 | -2.02742 |
| PLA2G15 | phospholipase A2, group XV | -2.0176 |
| LSM1 | LSM1, U6 small nuclear RNA associated | -2.0153 |
| ANXA1 | annexin A1 | -2.00505 |
