CRCGN008_HEPG2_24H:M08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description barium chloride dihydrate 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

143 genes differentially expressed following the CRCGN008_HEPG2_24H:M08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCNF cyclin F 5.64722
JADE2 jade family PHD finger 2 5.47968
MAMLD1 mastermind-like domain containing 1 5.3639
HLA-DMA major histocompatibility complex, class II, DM alpha 5.29115
E2F2 E2F transcription factor 2 5.0481
UBQLN2 ubiquilin 2 4.996
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.92995
PTPN6 protein tyrosine phosphatase, non-receptor type 6 4.84805
CBR3 carbonyl reductase 3 4.70935
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.50042
EGF epidermal growth factor 4.49405
BIRC2 baculoviral IAP repeat containing 2 4.2758
GPER1 G protein-coupled estrogen receptor 1 3.5905
KDM5A lysine (K)-specific demethylase 5A 3.57025
HEBP1 heme binding protein 1 3.4529
CHN1 chimerin 1 3.38905
SIRT3 sirtuin 3 3.18883
NPDC1 neural proliferation, differentiation and control, 1 3.1621
SLC75A1 solute carrier family 75 member 1 3.09145
CCDC85B coiled-coil domain containing 85B 3.0193
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.90215
SFTPB surfactant protein B 2.89975
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.79045
GRPR gastrin-releasing peptide receptor 2.761
LGALS14 lectin, galactoside-binding, soluble, 14 2.66115
KIF20A kinesin family member 20A 2.6257
WDTC1 WD and tetratricopeptide repeats 1 2.57273
CYB5RL cytochrome b5 reductase-like 2.53125
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.513
HMHB1 histocompatibility (minor) HB-1 2.47755
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.4508
PRKCE protein kinase C, epsilon 2.4231
DPF1 D4, zinc and double PHD fingers family 1 2.3989
FPGS folylpolyglutamate synthase 2.3933
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.38825
GEMIN7 gem (nuclear organelle) associated protein 7 2.37475
EVL Enah/Vasp-like 2.35665
ZNF236 zinc finger protein 236 2.33175
FAM50B family with sequence similarity 50, member B 2.32945
H1-3 H1.3 linker histone, cluster member 2.2983
MAP3K3 mitogen-activated protein kinase kinase kinase 3 2.2979
PTCD2 pentatricopeptide repeat domain 2 2.2866
DMTF1 cyclin D binding myb-like transcription factor 1 2.28163
CCDC198 coiled-coil domain containing 198 2.2519
PON3 paraoxonase 3 2.25025
NXPH4 neurexophilin 4 2.24955
CPNE2 copine II 2.24775
RGS14 regulator of G-protein signaling 14 2.24585
RAB21 RAB21, member RAS oncogene family 2.23385
ACR acrosin 2.2332
RPAIN RPA interacting protein 2.2259
PALB2 partner and localizer of BRCA2 2.22375
LUZP4 leucine zipper protein 4 2.2045
WDR11 WD repeat domain 11 2.20355
KDM5C lysine (K)-specific demethylase 5C 2.1966
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase 2.19565
SMAD2 SMAD family member 2 2.19482
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 2.19125
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.1817
RBFA ribosome binding factor A (putative) 2.18015
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.1625
TTPA tocopherol (alpha) transfer protein 2.1586
ANO10 anoctamin 10 2.14355
PDYN prodynorphin 2.1272
ERCC4 excision repair cross-complementation group 4 2.12635
PRODH proline dehydrogenase (oxidase) 1 2.1206
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.1202
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.1186
NOD1 nucleotide-binding oligomerization domain containing 1 2.11525
MIMS2 mitochondrial inner membrane scaffold 2 2.1124
TEC tec protein tyrosine kinase 2.10845
TTC21B tetratricopeptide repeat domain 21B 2.1075
FGB fibrinogen beta chain 2.1062
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.09685
DHRS1 dehydrogenase/reductase (SDR family) member 1 2.0954
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 2.0946
OR1F1 olfactory receptor, family 1, subfamily F, member 1 2.0797
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) 2.07835
GPX4 glutathione peroxidase 4 2.0626
IL22 interleukin 22 2.0607
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 2.0534
DELE1 DAP3 binding cell death enhancer 1 2.05115
LRRC23 leucine rich repeat containing 23 2.04842
SLC17A2 solute carrier family 17, member 2 2.04685
DNAI7 dynein axonemal intermediate chain 7 2.03675
DDN dendrin 2.03195
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 2.03045
SSX1 synovial sarcoma, X breakpoint 1 2.01395
SNAI1 snail family zinc finger 1 2.01385
RAG2 recombination activating gene 2 2.0128
C8A complement component 8, alpha polypeptide 2.0124
CD22 CD22 molecule 2.00985
CRYGB crystallin, gamma B 2.00375
IL9R interleukin 9 receptor 2.0018
ZNF862 zinc finger protein 862 2.00075

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -10.0
LDHD lactate dehydrogenase D -10.0
MAPK13 mitogen-activated protein kinase 13 -7.5023
TUBB6 tubulin, beta 6 class V -5.4762
ZNF586 zinc finger protein 586 -5.02285
CD320 CD320 molecule -4.86895
CCNB2 cyclin B2 -4.764
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.7278
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.6491
NRIP1 nuclear receptor interacting protein 1 -4.31493
GNAS GNAS complex locus -4.00493
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.95235
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.92645
NGRN neugrin, neurite outgrowth associated -3.39215
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.3785
ANKRD10 ankyrin repeat domain 10 -3.3365
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.30282
ZMIZ1 zinc finger, MIZ-type containing 1 -3.2153
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.14528
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.0253
SNX11 sorting nexin 11 -2.78115
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.74085
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.6707
PDHX pyruvate dehydrogenase complex, component X -2.64627
NAT10 N-acetyltransferase 10 (GCN5-related) -2.4129
EHF ets homologous factor -2.37395
PSRC1 proline/serine-rich coiled-coil 1 -2.37205
MRM3 mitochondrial rRNA methyltransferase 3 -2.3093
CHIC2 cysteine-rich hydrophobic domain 2 -2.29765
RFK riboflavin kinase -2.26785
TRIM16 tripartite motif containing 16 -2.2632
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.25547
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -2.22705
HSPA8 heat shock 70kDa protein 8 -2.21697
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.18635
ACAA1 acetyl-CoA acyltransferase 1 -2.17027
LYPD3 LY6/PLAUR domain containing 3 -2.1512
ADORA2B adenosine A2b receptor -2.1453
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.10082
LOC128966597 MAL-like protein -2.03125
ZWILCH zwilch kinetochore protein -2.02135
TMEM51 transmembrane protein 51 -2.02065
COTL1 coactosin-like F-actin binding protein 1 -2.013
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A -2.012
PARP12 poly (ADP-ribose) polymerase family, member 12 -2.01155
CAVIN2 caveolae associated protein 2 -2.00965
STOM stomatin -2.0057
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough -2.00235