CRCGN008_HEPG2_24H:M12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description barium chloride dihydrate 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

208 genes differentially expressed following the CRCGN008_HEPG2_24H:M12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIAM1 T-cell lymphoma invasion and metastasis 1 7.52227
ADRB2 adrenoceptor beta 2, surface 6.2674
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.56315
CHMP6 charged multivesicular body protein 6 5.4686
E2F2 E2F transcription factor 2 5.29605
HLA-DMA major histocompatibility complex, class II, DM alpha 5.29355
CBR3 carbonyl reductase 3 5.27145
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.1025
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.01895
AMDHD2 amidohydrolase domain containing 2 4.9598
NOSIP nitric oxide synthase interacting protein 4.8398
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.29105
GPER1 G protein-coupled estrogen receptor 1 4.22215
STK10 serine/threonine kinase 10 4.14905
PRR15L proline rich 15-like 3.95015
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.94285
PRKCH protein kinase C, eta 3.94225
RRAGA Ras-related GTP binding A 3.9047
SNAP25 synaptosomal-associated protein, 25kDa 3.86303
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.6494
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.42497
SIRPG signal-regulatory protein gamma 3.4141
CCL2 chemokine (C-C motif) ligand 2 3.3076
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.24268
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 3.2298
HEBP1 heme binding protein 1 3.20235
HLA-DRA major histocompatibility complex, class II, DR alpha 3.1701
TBPL1 TBP-like 1 3.1346
ZNF589 zinc finger protein 589 3.1298
ANO1 anoctamin 1, calcium activated chloride channel 3.0359
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 3.02065
PLSCR1 phospholipid scramblase 1 2.94005
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.89405
MRTFB myocardin related transcription factor B 2.82205
NUBP2 nucleotide binding protein 2 2.80785
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 2.8007
PRB3 proline-rich protein BstNI subfamily 3 2.7597
NOD2 nucleotide-binding oligomerization domain containing 2 2.7474
SMAD3 SMAD family member 3 2.73379
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.7087
SIX1 SIX homeobox 1 2.7031
ARHGAP28 Rho GTPase activating protein 28 2.68635
SHB Src homology 2 domain containing adaptor protein B 2.641
LAG3 lymphocyte-activation gene 3 2.62705
IL21 interleukin 21 2.62335
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 2.6075
TXNL4B thioredoxin-like 4B 2.5776
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.55455
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.53075
PEAK1 pseudopodium-enriched atypical kinase 1 2.52675
LPAR2 lysophosphatidic acid receptor 2 2.52052
GPR19 G protein-coupled receptor 19 2.5176
ASB7 ankyrin repeat and SOCS box containing 7 2.49795
PRB4 proline-rich protein BstNI subfamily 4 2.49705
CD101 CD101 molecule 2.4881
TM2D3 TM2 domain containing 3 2.4697
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.4304
ASXL2 additional sex combs like transcriptional regulator 2 2.42685
NKAIN1 Na+/K+ transporting ATPase interacting 1 2.4139
HOXA1 homeobox A1 2.4074
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.4066
ACOT2 acyl-CoA thioesterase 2 2.3934
CBX4 chromobox homolog 4 2.3921
CABP5 calcium binding protein 5 2.38185
CTXND1 cortexin domain containing 1 2.37575
FOXL1 forkhead box L1 2.37435
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 2.3674
UBASH3A ubiquitin associated and SH3 domain containing A 2.357
CD5 CD5 molecule 2.34535
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.34233
IL10RA interleukin 10 receptor, alpha 2.34065
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.31862
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 2.31145
ASIC4 acid sensing (proton gated) ion channel family member 4 2.3022
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.29295
LCT lactase 2.29155
GML glycosylphosphatidylinositol anchored molecule like 2.2697
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.258
GPR32 G protein-coupled receptor 32 2.25735
MAP3K6 mitogen-activated protein kinase kinase kinase 6 2.2518
PRDM16 PR domain containing 16 2.2487
RBM19 RNA binding motif protein 19 2.23852
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.23175
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 2.2249
BTN2A2 butyrophilin, subfamily 2, member A2 2.2192
RAB20 RAB20, member RAS oncogene family 2.21905
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.21645
COL11A2 collagen, type XI, alpha 2 2.21137
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.18462
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.18345
CD200R1 CD200 receptor 1 2.1826
ADAM19 ADAM metallopeptidase domain 19 2.18052
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.17615
NGF nerve growth factor (beta polypeptide) 2.1717
SIX2 SIX homeobox 2 2.15715
OPCML opioid binding protein/cell adhesion molecule-like 2.15408
COL9A1 collagen, type IX, alpha 1 2.14395
HOXD12 homeobox D12 2.1346
TLR5 toll-like receptor 5 2.13325
IL3RA interleukin 3 receptor, alpha (low affinity) 2.1321
BPIFA1 BPI fold containing family A, member 1 2.12605
NBAS neuroblastoma amplified sequence 2.11955
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.11535
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.10895
RAG2 recombination activating gene 2 2.1074
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.10653
OR1G1 olfactory receptor, family 1, subfamily G, member 1 2.10035
OR7E24 olfactory receptor, family 7, subfamily E, member 24 2.09775
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.0907
SIM1 single-minded family bHLH transcription factor 1 2.0903
FBXL8 F-box and leucine-rich repeat protein 8 2.08755
HLA-DMB major histocompatibility complex, class II, DM beta 2.08095
GFRA1 GDNF family receptor alpha 1 2.07485
PGBD5 piggyBac transposable element derived 5 2.07365
PTPRT protein tyrosine phosphatase, receptor type, T 2.0728
SKI SKI proto-oncogene 2.0661
CAPN10 calpain 10 2.0628
HAS2 hyaluronan synthase 2 2.06275
CSK c-src tyrosine kinase 2.05575
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.05575
CLEC1A C-type lectin domain family 1, member A 2.05495
TAC3 tachykinin 3 2.0531
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.0521
FOXA2 forkhead box A2 2.0504
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.0503
EDA2R ectodysplasin A2 receptor 2.0448
DNMBP dynamin binding protein 2.04145
SNN stannin 2.04027
MTMR10 myotubularin related protein 10 2.0346
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.0334
RYR3 ryanodine receptor 3 2.03315
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.03065
LY86 lymphocyte antigen 86 2.0293
PDE8B phosphodiesterase 8B 2.02895
PLXNB3 plexin B3 2.0266
CHRM5 cholinergic receptor, muscarinic 5 2.02615
SFT2D2 SFT2 domain containing 2 2.02105
PRB2 proline-rich protein BstNI subfamily 2 2.01832
OR1E2 olfactory receptor, family 1, subfamily E, member 2 2.0176
SPATA31A3 SPATA31 subfamily A, member 3 2.01535
AFF3 AF4/FMR2 family, member 3 2.01253
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 2.01055
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 2.0103
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.0089
HTN1 histatin 1 2.0089
MC3R melanocortin 3 receptor 2.0089
LYRM9 LYR motif containing 9 2.0088

decreased expression

Symbol Name Standardized Value
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -8.47363
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -5.91885
DNM1L dynamin 1-like -5.0393
PCNA proliferating cell nuclear antigen -5.0
CDC20 cell division cycle 20 -5.0
KDM3A lysine (K)-specific demethylase 3A -4.9954
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.8984
CCNB2 cyclin B2 -4.75715
PECR peroxisomal trans-2-enoyl-CoA reductase -4.75465
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.7395
RFC2 replication factor C (activator 1) 2, 40kDa -4.43773
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.3688
PUF60 poly-U binding splicing factor 60KDa -3.97865
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.8797
RNF167 ring finger protein 167 -3.6717
FADS2 fatty acid desaturase 2 -3.35525
OXA1L oxidase (cytochrome c) assembly 1-like -3.1515
ZMIZ1 zinc finger, MIZ-type containing 1 -2.92705
NVL nuclear VCP-like -2.84085
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.8247
PAIP1 poly(A) binding protein interacting protein 1 -2.81101
SPAG4 sperm associated antigen 4 -2.73675
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.70615
SQLE squalene epoxidase -2.69722
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -2.6861
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.6463
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.59005
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.57698
CDKN2AIP CDKN2A interacting protein -2.53885
PCNP PEST proteolytic signal containing nuclear protein -2.5142
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.5134
MSMO1 methylsterol monooxygenase 1 -2.49465
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.49035
TXNRD1 thioredoxin reductase 1 -2.4786
KIAA0930 KIAA0930 -2.46983
SCRIB scribbled planar cell polarity protein -2.46025
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.45703
IFT57 intraflagellar transport 57 -2.42965
TMEM267 transmembrane protein 267 -2.3964
MYO1D myosin ID -2.3618
NUP155 nucleoporin 155kDa -2.2716
HSPA6 heat shock 70kDa protein 6 (HSP70B') -2.22598
FKBP9 FK506 binding protein 9, 63 kDa -2.206
BIK BCL2-interacting killer (apoptosis-inducing) -2.1871
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.17275
SRP9 signal recognition particle 9kDa -2.1464
CDC25B cell division cycle 25B -2.12795
GMCL1 germ cell-less, spermatogenesis associated 1 -2.12095
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.1192
AVL9 AVL9 homolog (S. cerevisiase) -2.11298
HIPK1 homeodomain interacting protein kinase 1 -2.07657
ACTN4 actinin, alpha 4 -2.0742
ARL2 ADP-ribosylation factor-like 2 -2.069
H2AC19 H2A clustered histone 19 -2.061
GIPC1 GIPC PDZ domain containing family, member 1 -2.0505
INAVA innate immunity activator -2.0442
ICE1 interactor of little elongation complex ELL subunit 1 -2.03625
KLF11 Kruppel-like factor 11 -2.03145
TBC1D15 TBC1 domain family, member 15 -2.03
BRIX1 BRX1, biogenesis of ribosomes -2.02635
PADI2 peptidyl arginine deiminase, type II -2.0158