CRCGN008_HEPG2_24H:M14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(chloromethyl)pyridine.hcl 19.7 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

102 genes differentially expressed following the CRCGN008_HEPG2_24H:M14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRKCH protein kinase C, eta 6.63585
CIAO3 cytosolic iron-sulfur assembly component 3 5.5578
NMU neuromedin U 5.2477
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.9416
RPP38 ribonuclease P/MRP 38kDa subunit 4.895
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.7778
CXCR4 chemokine (C-X-C motif) receptor 4 4.3462
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.9497
SATB1 SATB homeobox 1 3.8265
PFKL phosphofructokinase, liver 3.76467
CHN1 chimerin 1 3.68765
CGRRF1 cell growth regulator with ring finger domain 1 3.6616
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.52163
ABHD6 abhydrolase domain containing 6 3.44458
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.4109
TIAM1 T-cell lymphoma invasion and metastasis 1 3.2972
TMEM186 transmembrane protein 186 3.26715
PMM2 phosphomannomutase 2 3.13135
SSBP2 single-stranded DNA binding protein 2 3.05185
CCNF cyclin F 3.0475
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.04035
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.82395
TBP TATA box binding protein 2.6653
PGP phosphoglycolate phosphatase 2.65615
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.65252
NENF neudesin neurotrophic factor 2.62375
GPR137B G protein-coupled receptor 137B 2.5822
MFGE8 milk fat globule-EGF factor 8 protein 2.5817
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.5522
PPP4C protein phosphatase 4, catalytic subunit 2.53735
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.5014
ZNF32 zinc finger protein 32 2.4849
ARID4B AT rich interactive domain 4B (RBP1-like) 2.45655
THOC6 THO complex 6 2.4112
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.39425
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.392
PRPF18 pre-mRNA processing factor 18 2.3414
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.26135
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2.2511
GATD3 glutamine amidotransferase class 1 domain containing 3 2.24983
TASOR2 transcription activation suppressor family member 2 2.22035
ALG11 ALG11, alpha-1,2-mannosyltransferase 2.1731
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 2.16235
GRB14 growth factor receptor-bound protein 14 2.1576
CRYAB crystallin, alpha B 2.1519
ZNF668 zinc finger protein 668 2.1476
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 2.1453
CXCR2 chemokine (C-X-C motif) receptor 2 2.1337
GRHPR glyoxylate reductase/hydroxypyruvate reductase 2.10968
SYNPO2L synaptopodin 2-like 2.1041
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 2.09735
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 2.08962
PVALB parvalbumin 2.0877
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.07635
ARID4A AT rich interactive domain 4A (RBP1-like) 2.06945
FRMD4A FERM domain containing 4A 2.06128
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.05945
CDK19 cyclin-dependent kinase 19 2.0543
RBM10 RNA binding motif protein 10 2.03712
THOC1 THO complex 1 2.01235
MVD mevalonate (diphospho) decarboxylase 2.0071
CD40 CD40 molecule, TNF receptor superfamily member 5 2.00215

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
CCNB2 cyclin B2 -9.3661
CASP7 caspase 7, apoptosis-related cysteine peptidase -7.7458
CCDC86 coiled-coil domain containing 86 -5.5316
OXA1L oxidase (cytochrome c) assembly 1-like -5.37535
TSEN2 TSEN2 tRNA splicing endonuclease subunit -5.3579
DNM1L dynamin 1-like -5.25395
ADI1 acireductone dioxygenase 1 -4.84645
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.2712
FBXO7 F-box protein 7 -4.0588
RFC2 replication factor C (activator 1) 2, 40kDa -3.4833
TXNRD1 thioredoxin reductase 1 -3.10545
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.82138
CCNB1 cyclin B1 -2.5779
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.45225
CD320 CD320 molecule -2.39875
CDC25B cell division cycle 25B -2.38445
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.3702
PDCD6IP programmed cell death 6 interacting protein -2.36995
TRIM24 tripartite motif containing 24 -2.29905
COCH cochlin -2.29665
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.20955
GLOD4 glyoxalase domain containing 4 -2.2053
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -2.18245
NRIP1 nuclear receptor interacting protein 1 -2.18152
SPATA6 spermatogenesis associated 6 -2.17705
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -2.1715
NHEJ1 nonhomologous end-joining factor 1 -2.1706
DCK deoxycytidine kinase -2.16625
EYA1 EYA transcriptional coactivator and phosphatase 1 -2.154
SYNGR3 synaptogyrin 3 -2.1341
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.1227
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 -2.1136
DDB1 damage-specific DNA binding protein 1, 127kDa -2.0815
DMTN dematin actin binding protein -2.0515
DERA deoxyribose-phosphate aldolase (putative) -2.04895
ODF1 outer dense fiber of sperm tails 1 -2.03975
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -2.0379
SPTSSA serine palmitoyltransferase, small subunit A -2.02475
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -2.0245