CRCGN008_HEPG2_24H:M15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(chloromethyl)pyridine.hcl 9.85 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

143 genes differentially expressed following the CRCGN008_HEPG2_24H:M15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF589 zinc finger protein 589 5.45993
GPATCH8 G patch domain containing 8 5.40632
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.3553
CBR3 carbonyl reductase 3 5.2381
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 5.14635
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.03565
STK10 serine/threonine kinase 10 5.0111
C2CD2 C2 calcium-dependent domain containing 2 4.96565
PRR15L proline rich 15-like 4.7644
JADE2 jade family PHD finger 2 4.73975
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.5349
CIAO3 cytosolic iron-sulfur assembly component 3 4.527
RPL39L ribosomal protein L39-like 4.50865
STIMATE STIM activating enhancer 4.49265
PIH1D1 PIH1 domain containing 1 4.31365
PEX11A peroxisomal biogenesis factor 11 alpha 4.249
CHN1 chimerin 1 4.0378
CD40 CD40 molecule, TNF receptor superfamily member 5 3.83889
TXNL4B thioredoxin-like 4B 3.81275
NOSIP nitric oxide synthase interacting protein 3.711
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.5714
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.54775
EGF epidermal growth factor 3.5222
EVL Enah/Vasp-like 3.3927
CDPF1 cysteine-rich, DPF motif domain containing 1 3.11075
ACTL6A actin-like 6A 3.06725
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.88987
ACP6 acid phosphatase 6, lysophosphatidic 2.8661
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.77708
TBCCD1 TBCC domain containing 1 2.7161
FOS FBJ murine osteosarcoma viral oncogene homolog 2.6939
SMYD5 SMYD family member 5 2.67125
MRNIP MRN complex interacting protein 2.61395
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.5889
RPA3 replication protein A3, 14kDa 2.53745
CXCL6 chemokine (C-X-C motif) ligand 6 2.50885
CFAP20 cilia and flagella associated protein 20 2.5034
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 2.4688
IST1 increased sodium tolerance 1 homolog (yeast) 2.4652
WDTC1 WD and tetratricopeptide repeats 1 2.45835
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.4154
GRWD1 glutamate-rich WD repeat containing 1 2.405
CTCF CCCTC-binding factor (zinc finger protein) 2.35395
PRMT1 protein arginine methyltransferase 1 2.32865
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 2.3085
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.3021
MCUR1 mitochondrial calcium uniporter regulator 1 2.29405
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.29365
CORO2B coronin, actin binding protein, 2B 2.2573
PLAT plasminogen activator, tissue 2.25465
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.254
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 2.23625
BTG3 BTG family, member 3 2.22723
PER1 period circadian clock 1 2.19285
SDC3 syndecan 3 2.18835
S100B S100 calcium binding protein B 2.1817
STEAP1 six transmembrane epithelial antigen of the prostate 1 2.18145
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 2.15915
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 2.1551
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 2.13527
DCBLD2 discoidin, CUB and LCCL domain containing 2 2.13
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 2.11845
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 2.118
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 2.10305
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.10255
LZTS3 leucine zipper, putative tumor suppressor family member 3 2.08525
PARL presenilin associated, rhomboid-like 2.0831
CXCL5 chemokine (C-X-C motif) ligand 5 2.05795
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 2.05425
ZNF580 zinc finger protein 580 2.0509
ANXA1 annexin A1 2.0361
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 2.036
GGNBP2 gametogenetin binding protein 2 2.0355
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.0078
YJU2B YJU2 splicing factor homolog B 2.0051
G0S2 G0/G1 switch 2 2.00285
PLA2G2D phospholipase A2, group IID 2.0003

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -8.27255
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.8732
WASHC4 WASH complex subunit 4 -5.65818
UGDH UDP-glucose 6-dehydrogenase -5.36215
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -5.19035
NT5DC2 5'-nucleotidase domain containing 2 -5.16795
C2CD5 C2 calcium-dependent domain containing 5 -5.11615
NRIP1 nuclear receptor interacting protein 1 -5.09415
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -5.02505
CDC20 cell division cycle 20 -5.0
LDHD lactate dehydrogenase D -4.6277
FGFR4 fibroblast growth factor receptor 4 -3.9867
HLA-DMA major histocompatibility complex, class II, DM alpha -3.8875
CCNB2 cyclin B2 -3.36225
BLCAP bladder cancer associated protein -3.32745
OXA1L oxidase (cytochrome c) assembly 1-like -3.30165
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.25835
HSPA8 heat shock 70kDa protein 8 -3.13775
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.03333
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 -3.0277
CARTPT CART prepropeptide -2.88395
HSPB3 heat shock 27kDa protein 3 -2.72735
HMG20B high mobility group 20B -2.68215
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.6486
GATA6 GATA binding protein 6 -2.61395
ZNF74 zinc finger protein 74 -2.58495
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 -2.58275
ATXN7L1 ataxin 7-like 1 -2.58175
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -2.53125
ACTC1 actin, alpha, cardiac muscle 1 -2.5291
ACTA1 actin, alpha 1, skeletal muscle -2.51265
PLA2G15 phospholipase A2, group XV -2.5119
TNNI1 troponin I type 1 (skeletal, slow) -2.47665
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.45865
SNAP25 synaptosomal-associated protein, 25kDa -2.43605
CAMK1 calcium/calmodulin-dependent protein kinase I -2.41705
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -2.3869
EFR3A EFR3 homolog A (S. cerevisiae) -2.3322
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.3312
RBM34 RNA binding motif protein 34 -2.3244
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.28795
GRAMD4 GRAM domain containing 4 -2.2792
ADAM9 ADAM metallopeptidase domain 9 -2.2639
CCR9 chemokine (C-C motif) receptor 9 -2.2616
KLHL41 kelch-like family member 41 -2.26075
ZWILCH zwilch kinetochore protein -2.1991
HSPB8 heat shock 22kDa protein 8 -2.19785
TH tyrosine hydroxylase -2.18075
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.17385
WDR70 WD repeat domain 70 -2.1715
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.1694
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.1572
VDAC3 voltage-dependent anion channel 3 -2.13803
ENDOG endonuclease G -2.13385
RBM47 RNA binding motif protein 47 -2.1296
MYL4 myosin, light chain 4, alkali; atrial, embryonic -2.12105
ZW10 zw10 kinetochore protein -2.11995
NSG2 neuronal vesicle trafficking associated 2 -2.10595
SH3YL1 SH3 and SYLF domain containing 1 -2.09865
RXRA retinoid X receptor, alpha -2.09538
CAPN9 calpain 9 -2.06642
MYL1 myosin, light chain 1, alkali; skeletal, fast -2.056
ZNF638 zinc finger protein 638 -2.0535
TENT4A terminal nucleotidyltransferase 4A -2.0459
PAIP1 poly(A) binding protein interacting protein 1 -2.0205
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) -2.0149