| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-(chloromethyl)pyridine.hcl 4.92 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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109 genes differentially expressed following the CRCGN008_HEPG2_24H:M16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CHMP6 | charged multivesicular body protein 6 | 5.42525 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | 5.3807 |
| ADRB2 | adrenoceptor beta 2, surface | 5.18485 |
| E2F2 | E2F transcription factor 2 | 5.11755 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 5.04005 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 5.03565 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 5.0352 |
| C2CD2 | C2 calcium-dependent domain containing 2 | 4.94235 |
| EPN2 | epsin 2 | 4.6765 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 4.60315 |
| SSBP2 | single-stranded DNA binding protein 2 | 4.29825 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 4.23445 |
| GPER1 | G protein-coupled estrogen receptor 1 | 4.09748 |
| EPHB2 | EPH receptor B2 | 3.94461 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.8183 |
| MAP7 | microtubule-associated protein 7 | 3.55372 |
| HSPA1A | heat shock 70kDa protein 1A | 3.4506 |
| PRR15L | proline rich 15-like | 3.422 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.38342 |
| HEBP1 | heme binding protein 1 | 3.29 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 3.27802 |
| LOC122526780 | uncharacterized LOC122526780 | 3.14535 |
| GATA2 | GATA binding protein 2 | 2.7845 |
| LCN2 | lipocalin 2 | 2.573 |
| CCNF | cyclin F | 2.48393 |
| SPRR2B | small proline-rich protein 2B | 2.44175 |
| EVPL | envoplakin | 2.4381 |
| CHN1 | chimerin 1 | 2.2984 |
| EPHA1 | EPH receptor A1 | 2.27495 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 2.25965 |
| PUF60 | poly-U binding splicing factor 60KDa | 2.25155 |
| S100A12 | S100 calcium binding protein A12 | 2.24495 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | 2.21855 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 2.1742 |
| NMU | neuromedin U | 2.1653 |
| WDR4 | WD repeat domain 4 | 2.16145 |
| MAP3K8 | mitogen-activated protein kinase kinase kinase 8 | 2.1526 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 2.1467 |
| CAPN5 | calpain 5 | 2.1402 |
| NEK4 | NIMA-related kinase 4 | 2.1362 |
| LRIG3 | leucine-rich repeats and immunoglobulin-like domains 3 | 2.115 |
| HSD17B1 | hydroxysteroid (17-beta) dehydrogenase 1 | 2.10215 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.0944 |
| PRMT7 | protein arginine methyltransferase 7 | 2.0738 |
| IVL | involucrin | 2.0695 |
| TRIOBP | TRIO and F-actin binding protein | 2.06248 |
| EPHA3 | EPH receptor A3 | 2.05717 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 2.05495 |
| ADGRB1 | adhesion G protein-coupled receptor B1 | 2.0509 |
| CSF3 | colony stimulating factor 3 (granulocyte) | 2.02905 |
| ATXN7 | ataxin 7 | 2.0275 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 2.02692 |
| TGM1 | transglutaminase 1 | 2.0228 |
| GPAA1 | glycosylphosphatidylinositol anchor attachment 1 | 2.0127 |
| RAB40C | RAB40C, member RAS oncogene family | 2.01025 |
| TNNC1 | troponin C type 1 (slow) | 2.00393 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIB3 | tribbles pseudokinase 3 | -10.0 |
| GNAS | GNAS complex locus | -7.76145 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -6.7209 |
| ADI1 | acireductone dioxygenase 1 | -5.71525 |
| LAP3 | leucine aminopeptidase 3 | -4.8503 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.7953 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.7383 |
| CCDC86 | coiled-coil domain containing 86 | -4.46125 |
| SLC35F2 | solute carrier family 35, member F2 | -4.29465 |
| LYPLA1 | lysophospholipase I | -4.26167 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.1859 |
| CCNB2 | cyclin B2 | -3.7738 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.2591 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -3.2349 |
| CD320 | CD320 molecule | -3.0614 |
| PABPC3 | poly(A) binding protein, cytoplasmic 3 | -2.79235 |
| RPN2 | ribophorin II | -2.68483 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | -2.58475 |
| RPL38 | ribosomal protein L38 | -2.55875 |
| RGS19 | regulator of G-protein signaling 19 | -2.49475 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -2.43965 |
| GDF15 | growth differentiation factor 15 | -2.4221 |
| MRPL15 | mitochondrial ribosomal protein L15 | -2.41505 |
| CUL1 | cullin 1 | -2.4147 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -2.4069 |
| NPIPB5 | nuclear pore complex interacting protein family, member B5 | -2.35785 |
| RLIM | ring finger protein, LIM domain interacting | -2.351 |
| FHL2 | four and a half LIM domains 2 | -2.33175 |
| CIC | capicua transcriptional repressor | -2.3312 |
| RPS13 | ribosomal protein S13 | -2.2808 |
| SLC35G2 | solute carrier family 35, member G2 | -2.2215 |
| RPLP2 | ribosomal protein, large, P2 | -2.21295 |
| RPL9 | ribosomal protein L9 | -2.2058 |
| RBM34 | RNA binding motif protein 34 | -2.18678 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.1619 |
| CSNK2B | casein kinase 2, beta polypeptide | -2.14045 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -2.13482 |
| RPS24 | ribosomal protein S24 | -2.12225 |
| RPL23A | ribosomal protein L23a | -2.10532 |
| RPL32 | ribosomal protein L32 | -2.10375 |
| RPS7 | ribosomal protein S7 | -2.10048 |
| RPS17 | ribosomal protein S17 | -2.08715 |
| PIGP | phosphatidylinositol glycan anchor biosynthesis, class P | -2.0559 |
| ATF4 | activating transcription factor 4 | -2.0505 |
| MTNAP1 | mitochondrial nucleoid associated protein 1 | -2.0494 |
| ZNF286A | zinc finger protein 286A | -2.04545 |
| DNAAF5 | dynein, axonemal, assembly factor 5 | -2.03155 |
| UBC | ubiquitin C | -2.02575 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -2.017 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | -2.0136 |
| RPL41 | ribosomal protein L41 | -2.01345 |
| ELAVL2 | ELAV like neuron-specific RNA binding protein 2 | -2.0119 |
| TPT1 | tumor protein, translationally-controlled 1 | -2.01083 |
