CRCGN008_HEPG2_24H:M17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(chloromethyl)pyridine.hcl 2.46 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

198 genes differentially expressed following the CRCGN008_HEPG2_24H:M17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 5.7352
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.23145
LAGE3 L antigen family, member 3 5.22215
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.16955
PPARG peroxisome proliferator-activated receptor gamma 5.1536
CBR3 carbonyl reductase 3 5.06375
AMDHD2 amidohydrolase domain containing 2 5.0412
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.97435
E2F2 E2F transcription factor 2 4.846
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.81265
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.622
CCL2 chemokine (C-C motif) ligand 2 4.349
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.24695
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.10825
PRR15L proline rich 15-like 3.87195
GPER1 G protein-coupled estrogen receptor 1 3.63077
MAP7 microtubule-associated protein 7 3.36152
H2BC12 H2B clustered histone 12 3.2457
SATB1 SATB homeobox 1 3.2163
EVL Enah/Vasp-like 3.2073
STXBP1 syntaxin binding protein 1 3.1046
TIAM1 T-cell lymphoma invasion and metastasis 1 3.0515
C8G complement component 8, gamma polypeptide 3.01255
JADE2 jade family PHD finger 2 2.98758
ADAM10 ADAM metallopeptidase domain 10 2.98482
RAG2 recombination activating gene 2 2.95835
TXLNG taxilin gamma 2.9482
IL12RB2 interleukin 12 receptor, beta 2 2.7748
KLC3 kinesin light chain 3 2.7702
CCN6 cellular communication network factor 6 2.74955
EPHA3 EPH receptor A3 2.67752
CSAG2 CSAG family, member 2 2.64015
WDTC1 WD and tetratricopeptide repeats 1 2.62458
PGR progesterone receptor 2.53785
RPAIN RPA interacting protein 2.526
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 2.52265
CENPQ centromere protein Q 2.51115
TXNL4B thioredoxin-like 4B 2.5091
WDR4 WD repeat domain 4 2.49775
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.49635
GPR176 G protein-coupled receptor 176 2.46735
MAGEA11 melanoma antigen family A11 2.42645
ATAD5 ATPase family, AAA domain containing 5 2.42295
UBE4B ubiquitination factor E4B 2.41432
CCL8 chemokine (C-C motif) ligand 8 2.40265
DAO D-amino-acid oxidase 2.39825
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.39625
JPH3 junctophilin 3 2.38635
IRF9 interferon regulatory factor 9 2.38135
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) 2.3772
MIA melanoma inhibitory activity 2.37585
NRXN2 neurexin 2 2.3695
TGDS TDP-glucose 4,6-dehydratase 2.36285
TMEM14A transmembrane protein 14A 2.35865
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.3583
TTPA tocopherol (alpha) transfer protein 2.3535
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 2.3457
FGF20 fibroblast growth factor 20 2.3407
LOC100533997 MAGEA10-MAGEA5 readthrough 2.3207
FCRLB Fc receptor-like B 2.32045
CST2 cystatin SA 2.2921
KRT34 keratin 34, type I 2.28305
HPR haptoglobin-related protein 2.28225
MCTP1 multiple C2 domains, transmembrane 1 2.27915
CER1 cerberus 1, DAN family BMP antagonist 2.2759
IL15 interleukin 15 2.27005
MAGEC2 melanoma antigen family C2 2.26925
RPUSD2 RNA pseudouridylate synthase domain containing 2 2.2669
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.2662
PPIAL4H peptidylprolyl isomerase A like 4H 2.2544
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.2486
MRPL4 mitochondrial ribosomal protein L4 2.2379
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 2.236
ANAPC10 anaphase promoting complex subunit 10 2.22495
IL7 interleukin 7 2.22375
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.2231
KRT9 keratin 9, type I 2.2207
OBP2A odorant binding protein 2A 2.20015
SIAH2 siah E3 ubiquitin protein ligase 2 2.1984
OXT oxytocin/neurophysin I prepropeptide 2.19225
TEDC2 tubulin epsilon and delta complex 2 2.19005
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.1899
LIN7B lin-7 homolog B (C. elegans) 2.18785
GATA4 GATA binding protein 4 2.1865
TLR4 toll-like receptor 4 2.18435
RMDN1 regulator of microtubule dynamics 1 2.17595
DHODH dihydroorotate dehydrogenase (quinone) 2.16437
CT55 cancer/testis antigen 55 2.16055
CCP110 centriolar coiled coil protein 110kDa 2.15965
TREX2 three prime repair exonuclease 2 2.1527
ETNPPL ethanolamine-phosphate phospho-lyase 2.1525
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.1521
DTWD1 DTW domain containing 1 2.14735
ARPP21 cAMP-regulated phosphoprotein, 21kDa 2.13795
SSTR1 somatostatin receptor 1 2.12935
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.1282
OASL 2'-5'-oligoadenylate synthetase-like 2.12585
UFM1 ubiquitin-fold modifier 1 2.124
FAM120C family with sequence similarity 120C 2.12215
MAGEA4 melanoma antigen family A4 2.1197
FGF3 fibroblast growth factor 3 2.11945
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 2.11685
GMFB glia maturation factor, beta 2.11042
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 2.1076
RIOK2 RIO kinase 2 2.0983
NADK NAD kinase 2.09794
FOXB1 forkhead box B1 2.09445
CDH12 cadherin 12, type 2 (N-cadherin 2) 2.09405
TAC3 tachykinin 3 2.09355
GPR37L1 G protein-coupled receptor 37 like 1 2.09145
RPA4 replication protein A4, 30kDa 2.08785
POU3F3 POU class 3 homeobox 3 2.08555
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.08457
IGFBP4 insulin-like growth factor binding protein 4 2.07845
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa 2.07675
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 2.0702
S100A3 S100 calcium binding protein A3 2.0589
TLX3 T-cell leukemia homeobox 3 2.05875
ASCL2 achaete-scute family bHLH transcription factor 2 2.0516
SIX3 SIX homeobox 3 2.0505
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.04693
LRRC42 leucine rich repeat containing 42 2.04435
LIPC lipase, hepatic 2.0428
GUF1 GUF1 GTPase homolog (S. cerevisiae) 2.0402
SLC10A3 solute carrier family 10, member 3 2.04
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.03835
RPL10L ribosomal protein L10-like 2.03115
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.02935
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 2.02615
CD40 CD40 molecule, TNF receptor superfamily member 5 2.0244
HOXC5 homeobox C5 2.02415
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 2.0196
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 2.0195
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 2.01372
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 2.01285
R3HCC1L R3H domain and coiled-coil containing 1-like 2.0085
IL26 interleukin 26 2.0056
PVR poliovirus receptor 2.00404
PRMT7 protein arginine methyltransferase 7 2.0007

decreased expression

Symbol Name Standardized Value
NT5DC2 5'-nucleotidase domain containing 2 -10.0
PCNA proliferating cell nuclear antigen -10.0
CCNB2 cyclin B2 -9.08485
GNAS GNAS complex locus -7.48022
ISOC1 isochorismatase domain containing 1 -5.4283
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.24655
TUBB6 tubulin, beta 6 class V -5.0583
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.9227
ARID5B AT rich interactive domain 5B (MRF1-like) -4.89805
EGF epidermal growth factor -4.8464
LDHD lactate dehydrogenase D -4.82795
INPP1 inositol polyphosphate-1-phosphatase -4.77845
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.62225
KDM3A lysine (K)-specific demethylase 3A -4.61925
PEG10 paternally expressed 10 -4.58453
CD320 CD320 molecule -4.47005
CAB39 calcium binding protein 39 -4.05425
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.0538
MAPK13 mitogen-activated protein kinase 13 -4.03743
CTNND1 catenin (cadherin-associated protein), delta 1 -3.29918
TES testin LIM domain protein -3.21638
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.02335
HMG20B high mobility group 20B -2.96623
PECR peroxisomal trans-2-enoyl-CoA reductase -2.8866
OXA1L oxidase (cytochrome c) assembly 1-like -2.75215
RBM15B RNA binding motif protein 15B -2.7499
HEG1 heart development protein with EGF-like domains 1 -2.6075
COX5A cytochrome c oxidase subunit Va -2.6017
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.53495
ACTG1 actin gamma 1 -2.50248
TMED3 transmembrane emp24 protein transport domain containing 3 -2.47545
A2M alpha-2-macroglobulin -2.40265
ATRN attractin -2.3954
REEP5 receptor accessory protein 5 -2.3935
NVL nuclear VCP-like -2.3712
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.36938
DUSP2 dual specificity phosphatase 2 -2.33615
INAVA innate immunity activator -2.3149
SOX11 SRY (sex determining region Y)-box 11 -2.31438
PANK2 pantothenate kinase 2 -2.30745
ADGRF5 adhesion G protein-coupled receptor F5 -2.30072
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.28795
ACVR1 activin A receptor, type I -2.2811
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.2145
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.21025
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.19933
TMEM230 transmembrane protein 230 -2.1925
FKBP4 FK506 binding protein 4, 59kDa -2.17292
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.10812
ATP5PB ATP synthase peripheral stalk-membrane subunit b -2.0796
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.07833
EEF2 eukaryotic translation elongation factor 2 -2.06997
PFDN1 prefoldin subunit 1 -2.05675
LPAR6 lysophosphatidic acid receptor 6 -2.0563
MAP2K1 mitogen-activated protein kinase kinase 1 -2.0384
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -2.03178
ISYNA1 inositol-3-phosphate synthase 1 -2.02895
CYTL1 cytokine-like 1 -2.0207
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.0191