CRCGN008_HEPG2_24H:M19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ampicillin 34.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

98 genes differentially expressed following the CRCGN008_HEPG2_24H:M19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 6.5686
CYCS cytochrome c, somatic 6.2137
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.70735
TIMP2 TIMP metallopeptidase inhibitor 2 5.63875
RPP38 ribonuclease P/MRP 38kDa subunit 5.3467
E2F2 E2F transcription factor 2 5.1389
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.8964
ABHD6 abhydrolase domain containing 6 4.68867
HOXA10 homeobox A10 4.63538
CCL2 chemokine (C-C motif) ligand 2 4.3438
HEBP1 heme binding protein 1 4.16205
ARL4C ADP-ribosylation factor-like 4C 3.8316
ANO1 anoctamin 1, calcium activated chloride channel 3.82535
DYNLT3 dynein, light chain, Tctex-type 3 3.81545
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 3.46745
SNAP25 synaptosomal-associated protein, 25kDa 3.34783
JADE2 jade family PHD finger 2 3.19383
MYOM2 myomesin 2 2.81975
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.79995
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.7649
MAP7 microtubule-associated protein 7 2.67118
AK5 adenylate kinase 5 2.64645
SIRT3 sirtuin 3 2.58478
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.5364
TBXA2R thromboxane A2 receptor 2.49158
ADAT1 adenosine deaminase, tRNA-specific 1 2.45965
FOS FBJ murine osteosarcoma viral oncogene homolog 2.40805
PLK3 polo-like kinase 3 2.4036
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.39312
HYAL4 hyaluronoglucosaminidase 4 2.3916
AP1AR adaptor-related protein complex 1 associated regulatory protein 2.34855
CORO1A coronin, actin binding protein, 1A 2.33005
LIPC lipase, hepatic 2.32105
DEPDC5 DEP domain containing 5 2.31275
GALP galanin-like peptide 2.29755
OGDHL oxoglutarate dehydrogenase-like 2.26205
SGPP2 sphingosine-1-phosphate phosphatase 2 2.25065
KCTD9 potassium channel tetramerization domain containing 9 2.2494
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.23305
ACTA1 actin, alpha 1, skeletal muscle 2.2186
CEP57 centrosomal protein 57kDa 2.21786
TMEM38B transmembrane protein 38B 2.21475
MRGBP MRG/MORF4L binding protein 2.20005
MCUR1 mitochondrial calcium uniporter regulator 1 2.19565
CA8 carbonic anhydrase VIII 2.17695
ADGRE1 adhesion G protein-coupled receptor E1 2.16085
OXSM 3-oxoacyl-ACP synthase, mitochondrial 2.15435
LOC102725023 killer cell immunoglobulin-like receptor 2DS3 allele 0020101 2.1281
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.1253
KIF20A kinesin family member 20A 2.12205
HAO2 hydroxyacid oxidase 2 (long chain) 2.11415
LY6H lymphocyte antigen 6 complex, locus H 2.11115
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.10738
SHBG sex hormone-binding globulin 2.0982
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 2.09815
FPGS folylpolyglutamate synthase 2.0942
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 2.08815
CUTC cutC copper transporter 2.07965
DDN dendrin 2.0744
STX10 syntaxin 10 2.0677
LAD1 ladinin 1 2.06415
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 2.05026
TXNL4B thioredoxin-like 4B 2.0369
BIRC2 baculoviral IAP repeat containing 2 2.0346
DCHS2 dachsous cadherin-related 2 2.0206
SYN1 synapsin I 2.00125

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.1979
ISOC1 isochorismatase domain containing 1 -5.2708
ZNF586 zinc finger protein 586 -5.00545
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.85895
TSPAN4 tetraspanin 4 -4.81917
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.7862
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -4.76472
SLC35F2 solute carrier family 35, member F2 -4.5865
B4GAT1 beta-1,4-glucuronyltransferase 1 -4.31925
GNAS GNAS complex locus -3.75291
RHEB Ras homolog enriched in brain -3.14332
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.01515
OXA1L oxidase (cytochrome c) assembly 1-like -2.9125
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.71653
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.64235
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.59825
SPAG4 sperm associated antigen 4 -2.5969
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -2.54002
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.44735
TENT4A terminal nucleotidyltransferase 4A -2.3973
COL4A5 collagen, type IV, alpha 5 -2.39335
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.37647
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -2.29155
NXN nucleoredoxin -2.26335
TM9SF2 transmembrane 9 superfamily member 2 -2.2632
REEP5 receptor accessory protein 5 -2.13963
MEIS2 Meis homeobox 2 -2.12125
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 -2.0664
ZNF282 zinc finger protein 282 -2.0625
MNDA myeloid cell nuclear differentiation antigen -2.04235
STAMBP STAM binding protein -2.0301
ACP3 acid phosphatase 3 -2.02985