CRCGN008_HEPG2_24H:M21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ampicillin 8.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

88 genes differentially expressed following the CRCGN008_HEPG2_24H:M21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ANO1 anoctamin 1, calcium activated chloride channel 7.31925
BACE2 beta-site APP-cleaving enzyme 2 5.4286
AMDHD2 amidohydrolase domain containing 2 5.29255
ADGRE5 adhesion G protein-coupled receptor E5 5.2331
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.16755
STK10 serine/threonine kinase 10 4.99342
CIAO3 cytosolic iron-sulfur assembly component 3 4.92915
E2F2 E2F transcription factor 2 4.9167
EPHA3 EPH receptor A3 4.86895
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.85645
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.55575
EGF epidermal growth factor 4.44205
FZD7 frizzled class receptor 7 4.08715
SSBP2 single-stranded DNA binding protein 2 4.0817
SNAP25 synaptosomal-associated protein, 25kDa 3.8336
GATA3 GATA binding protein 3 3.27573
VGLL4 vestigial-like family member 4 3.22985
HSPA1A heat shock 70kDa protein 1A 3.1784
MAP7 microtubule-associated protein 7 3.07067
TBP TATA box binding protein 2.92445
H2BC12 H2B clustered histone 12 2.85295
ZNF589 zinc finger protein 589 2.75217
CHN1 chimerin 1 2.5399
ZDHHC14 zinc finger, DHHC-type containing 14 2.5121
NRTN neurturin 2.50695
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.5023
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.4961
LCN2 lipocalin 2 2.48145
JADE2 jade family PHD finger 2 2.4812
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 2.46915
STAG3 stromal antigen 3 2.4247
HDAC1 histone deacetylase 1 2.41815
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.3757
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 2.36645
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 2.35485
TRAF5 TNF receptor-associated factor 5 2.34425
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.2588
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 2.1983
SPATA31C1 SPATA31 subfamily C, member 1 2.18835
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 2.14035
METTL25B methyltransferase like 25B 2.1236
TERF2 telomeric repeat binding factor 2 2.09895
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.09401
RERGL RERG/RAS-like 2.0836
CLK3 CDC-like kinase 3 2.0578
TSPAN2 tetraspanin 2 2.04845
PPP4R3B protein phosphatase 4 regulatory subunit 3B 2.0217
CLCN7 chloride channel, voltage-sensitive 7 2.01663
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.0021
NUP62CL nucleoporin 62kDa C-terminal like 2.00115

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.81475
NRIP1 nuclear receptor interacting protein 1 -5.00572
ZNF586 zinc finger protein 586 -4.93095
NT5DC2 5'-nucleotidase domain containing 2 -4.7936
CCNB2 cyclin B2 -4.7368
VAT1 vesicle amine transport 1 -4.2011
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -3.28825
RGS2 regulator of G-protein signaling 2 -3.25125
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.02373
HSPA8 heat shock 70kDa protein 8 -2.97723
MTA1 metastasis associated 1 -2.9199
TENT4A terminal nucleotidyltransferase 4A -2.91355
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.7383
TXNDC9 thioredoxin domain containing 9 -2.61683
CCNB1 cyclin B1 -2.4916
PWWP3A PWWP domain containing 3A, DNA repair factor -2.48165
TARS1 threonyl-tRNA synthetase 1 -2.4489
NMRK1 nicotinamide riboside kinase 1 -2.3203
LPCAT1 lysophosphatidylcholine acyltransferase 1 -2.30535
CD1B CD1b molecule -2.1951
PRPF4 pre-mRNA processing factor 4 -2.18237
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like -2.16515
GLOD4 glyoxalase domain containing 4 -2.1499
ITGB1BP1 integrin beta 1 binding protein 1 -2.13087
CD1E CD1e molecule -2.1097
CNTLN centlein, centrosomal protein -2.0956
MEMO1 mediator of cell motility 1 -2.07525
ZNF134 zinc finger protein 134 -2.0683
RIC8B RIC8 guanine nucleotide exchange factor B -2.0599
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -2.05825
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 -2.0355
RBM34 RNA binding motif protein 34 -2.03357
JPT1 Jupiter microtubule associated homolog 1 -2.03055
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.0263
SMC6 structural maintenance of chromosomes 6 -2.01705
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.0124
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.0051
ZNF222 zinc finger protein 222 -2.0014