CRCGN008_HEPG2_24H:M23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ampicillin 2.13 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN008_HEPG2_24H:M23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.62955
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.32865
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.2575
STIMATE STIM activating enhancer 5.1974
BACE2 beta-site APP-cleaving enzyme 2 5.10785
SQOR sulfide quinone oxidoreductase 4.9534
UBQLN2 ubiquilin 2 4.943
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.8094
CIAO3 cytosolic iron-sulfur assembly component 3 4.64375
BIRC2 baculoviral IAP repeat containing 2 4.3206
PLSCR1 phospholipid scramblase 1 4.10975
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.58485
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.57943
MAP7 microtubule-associated protein 7 3.45953
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.97102
ADAT1 adenosine deaminase, tRNA-specific 1 2.6746
BPHL biphenyl hydrolase-like (serine hydrolase) 2.6381
MRPL58 mitochondrial ribosomal protein L58 2.6377
RNF123 ring finger protein 123 2.58495
SIRT3 sirtuin 3 2.58088
EPHA3 EPH receptor A3 2.53377
ZNF589 zinc finger protein 589 2.52842
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 2.5104
GPATCH8 G patch domain containing 8 2.47487
TKFC triokinase/FMN cyclase 2.25425
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.23558
STXBP2 syntaxin binding protein 2 2.2337
TRIM13 tripartite motif containing 13 2.20525
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.1839
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.18357
ADAM28 ADAM metallopeptidase domain 28 2.16655
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.1536
TUBGCP4 tubulin, gamma complex associated protein 4 2.12215
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 2.1048
ETNPPL ethanolamine-phosphate phospho-lyase 2.0976
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.0675
MRPL30 mitochondrial ribosomal protein L30 2.04095
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.0406
BRAF B-Raf proto-oncogene, serine/threonine kinase 2.0346
AP1AR adaptor-related protein complex 1 associated regulatory protein 2.0344
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.0255
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 2.0121
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 2.00525

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CCNB2 cyclin B2 -9.005
TLCD3A TLC domain containing 3A -5.08955
PCNA proliferating cell nuclear antigen -5.0
C2CD5 C2 calcium-dependent domain containing 5 -4.69495
GNAS GNAS complex locus -4.13656
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -3.5148
ZNF586 zinc finger protein 586 -3.2041
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.1851
SCARB1 scavenger receptor class B, member 1 -3.014
OXA1L oxidase (cytochrome c) assembly 1-like -2.9718
CD58 CD58 molecule -2.89518
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.89405
ITGB1BP1 integrin beta 1 binding protein 1 -2.5191
CDC25B cell division cycle 25B -2.4075
DDIT4 DNA-damage-inducible transcript 4 -2.39635
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.39453
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.346
FBXL12 F-box and leucine-rich repeat protein 12 -2.322
GOLGA8N golgin A8 family, member N -2.3216
MTA1 metastasis associated 1 -2.2227
FASTKD3 FAST kinase domains 3 -2.1452
WASHC4 WASH complex subunit 4 -2.12183
CCL3L3 chemokine (C-C motif) ligand 3-like 3 -2.00865