CRCGN008_HEPG2_24H:M24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ampicillin 1.06 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

98 genes differentially expressed following the CRCGN008_HEPG2_24H:M24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 8.018
ADRB2 adrenoceptor beta 2, surface 5.36995
LAGE3 L antigen family, member 3 4.7642
ABHD6 abhydrolase domain containing 6 4.71445
ANO1 anoctamin 1, calcium activated chloride channel 4.6644
PEX11A peroxisomal biogenesis factor 11 alpha 4.24237
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.21945
GSTZ1 glutathione S-transferase zeta 1 4.2103
DENND2D DENN/MADD domain containing 2D 3.9158
VAV3 vav 3 guanine nucleotide exchange factor 3.85643
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.84965
CD40 CD40 molecule, TNF receptor superfamily member 5 3.40529
CCL2 chemokine (C-C motif) ligand 2 3.3033
EPN2 epsin 2 3.27225
VGLL4 vestigial-like family member 4 3.17133
CHN1 chimerin 1 3.1458
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.11125
KDM5A lysine (K)-specific demethylase 5A 3.0605
SSBP2 single-stranded DNA binding protein 2 2.79205
JADE2 jade family PHD finger 2 2.7821
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.76347
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.7386
TXNL4B thioredoxin-like 4B 2.7207
CCNF cyclin F 2.71815
MZB1 marginal zone B and B1 cell-specific protein 2.5401
GARRE1 granule associated Rac and RHOG effector 1 2.53595
FES FES proto-oncogene, tyrosine kinase 2.5316
CYCS cytochrome c, somatic 2.3869
EOLA1 endothelium and lymphocyte associated ASCH domain 1 2.356
IL2RG interleukin 2 receptor, gamma 2.34425
INTS13 integrator complex subunit 13 2.29785
MAGEA6 melanoma antigen family A6 2.27253
MAGEA12 melanoma antigen family A12 2.26125
TBP TATA box binding protein 2.25625
HAUS7 HAUS augmin-like complex, subunit 7 2.23885
CSAG2 CSAG family, member 2 2.20765
FCHSD2 FCH and double SH3 domains 2 2.18725
ZNF232 zinc finger protein 232 2.14635
WASF3 WAS protein family, member 3 2.1454
POLR1E polymerase (RNA) I polypeptide E, 53kDa 2.1433
MAGEA2B melanoma antigen family A2B 2.12815
STARD5 StAR-related lipid transfer (START) domain containing 5 2.12585
TM9SF2 transmembrane 9 superfamily member 2 2.1191
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.1103
EPHA3 EPH receptor A3 2.10622
GMEB1 glucocorticoid modulatory element binding protein 1 2.10265
LGALS7B lectin, galactoside-binding, soluble, 7B 2.10085
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 2.1005
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 2.09305
RTN3 reticulon 3 2.08095
RECQL4 RecQ protein-like 4 2.0792
WDR44 WD repeat domain 44 2.0451
FOXK2 forkhead box K2 2.0389
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.02715
IL18R1 interleukin 18 receptor 1 2.0236
AP5M1 adaptor-related protein complex 5, mu 1 subunit 2.01015

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
CCNB2 cyclin B2 -8.9967
CASP7 caspase 7, apoptosis-related cysteine peptidase -7.68995
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.29465
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.78895
UGDH UDP-glucose 6-dehydrogenase -4.53965
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.8825
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.8667
MAPK13 mitogen-activated protein kinase 13 -3.60437
CLIC4 chloride intracellular channel 4 -3.52342
GNAS GNAS complex locus -3.48836
MAP7 microtubule-associated protein 7 -3.48462
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 -3.43758
DDIT4 DNA-damage-inducible transcript 4 -3.38785
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.72413
TWF2 twinfilin actin binding protein 2 -2.6713
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.61973
CCNB1 cyclin B1 -2.5651
SNX11 sorting nexin 11 -2.5573
PEG10 paternally expressed 10 -2.5
RPP40 ribonuclease P/MRP 40kDa subunit -2.48145
MEPE matrix extracellular phosphoglycoprotein -2.3765
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.2967
DEXI Dexi homolog (mouse) -2.28365
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) -2.27925
MEA1 male-enhanced antigen 1 -2.2337
BCAS3 breast carcinoma amplified sequence 3 -2.22615
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 -2.20725
COG7 component of oligomeric golgi complex 7 -2.1972
GTPBP2 GTP binding protein 2 -2.185
CYB5A cytochrome b5 type A (microsomal) -2.13572
ZFAND3 zinc finger, AN1-type domain 3 -2.1265
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -2.07685
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -2.07655
RAB1B RAB1B, member RAS oncogene family -2.06565
VANGL1 VANGL planar cell polarity protein 1 -2.046
POMT1 protein-O-mannosyltransferase 1 -2.04375
CMTR1 cap methyltransferase 1 -2.0277
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -2.0184
ARID5B AT rich interactive domain 5B (MRF1-like) -2.0178
TARBP2 TAR (HIV-1) RNA binding protein 2 -2.011
LYRM4 LYR motif containing 4 -2.0095