CRCGN008_HEPG2_24H:N03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1-dichloroethane 9.65 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

220 genes differentially expressed following the CRCGN008_HEPG2_24H:N03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INTS3 integrator complex subunit 3 5.33005
PLS1 plastin 1 5.267
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.25115
STIMATE STIM activating enhancer 5.0814
HLA-DMA major histocompatibility complex, class II, DM alpha 4.93465
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.89865
PPARG peroxisome proliferator-activated receptor gamma 4.7896
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.6965
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.2335
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.7821
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.69208
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.64967
GPER1 G protein-coupled estrogen receptor 1 3.6265
CDK8 cyclin-dependent kinase 8 3.59875
TBC1D31 TBC1 domain family, member 31 3.4222
MAP7 microtubule-associated protein 7 3.41438
MCOLN1 mucolipin 1 3.3689
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 3.29032
RBM38 RNA binding motif protein 38 3.0559
LPAR2 lysophosphatidic acid receptor 2 2.98915
CLCN3 chloride channel, voltage-sensitive 3 2.98096
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.96723
CYCS cytochrome c, somatic 2.9354
NT5DC2 5'-nucleotidase domain containing 2 2.8979
TBX21 T-box 21 2.8557
ZNF589 zinc finger protein 589 2.80572
UBE2M ubiquitin-conjugating enzyme E2M 2.74895
ZNF274 zinc finger protein 274 2.74455
UBL5 ubiquitin-like 5 2.72275
GPATCH8 G patch domain containing 8 2.68643
DNM2 dynamin 2 2.6814
BIN2 bridging integrator 2 2.6736
ZNF862 zinc finger protein 862 2.643
CHEK2 checkpoint kinase 2 2.63115
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.63055
ANO1 anoctamin 1, calcium activated chloride channel 2.6305
CDC37 cell division cycle 37 2.6121
MED24 mediator complex subunit 24 2.58535
COG4 component of oligomeric golgi complex 4 2.58465
WASF3 WAS protein family, member 3 2.5521
CCNF cyclin F 2.5374
IL22RA1 interleukin 22 receptor, alpha 1 2.5281
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.5188
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.51383
TRAPPC11 trafficking protein particle complex 11 2.50995
ACTR6 ARP6 actin-related protein 6 homolog (yeast) 2.4963
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.4961
ABHD4 abhydrolase domain containing 4 2.48445
BTN3A1 butyrophilin, subfamily 3, member A1 2.46885
NUP205 nucleoporin 205kDa 2.45485
ZNF518A zinc finger protein 518A 2.4499
RINT1 RAD50 interactor 1 2.4368
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 2.4343
CXCR3 chemokine (C-X-C motif) receptor 3 2.41225
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) 2.39175
TBP TATA box binding protein 2.3793
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 2.36838
GTF2A2 general transcription factor IIA, 2, 12kDa 2.368
PLSCR3 phospholipid scramblase 3 2.36785
CARD8 caspase recruitment domain family, member 8 2.35095
AMDHD2 amidohydrolase domain containing 2 2.34755
KLHL9 kelch-like family member 9 2.32508
CASP8AP2 caspase 8 associated protein 2 2.31745
DENND4B DENN/MADD domain containing 4B 2.29565
DGKQ diacylglycerol kinase, theta 110kDa 2.2932
CLTC clathrin, heavy chain (Hc) 2.28675
TBX2 T-box 2 2.2756
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.27445
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 2.27198
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.26405
RTL8C retrotransposon Gag like 8C 2.2599
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.24015
ATP5MF ATP synthase membrane subunit f 2.23855
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.2256
ACYP1 acylphosphatase 1, erythrocyte (common) type 2.2171
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.21445
CD248 CD248 molecule, endosialin 2.2002
PERP PERP, TP53 apoptosis effector 2.1959
DDR1 discoidin domain receptor tyrosine kinase 1 2.19568
METTL4 methyltransferase like 4 2.1881
ITGA6 integrin, alpha 6 2.18753
ELP5 elongator acetyltransferase complex subunit 5 2.1781
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.1742
BIRC2 baculoviral IAP repeat containing 2 2.17285
MOSPD1 motile sperm domain containing 1 2.1688
DNM1L dynamin 1-like 2.1667
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 2.14165
ARFIP2 ADP-ribosylation factor interacting protein 2 2.13665
BLCAP bladder cancer associated protein 2.1288
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.12435
HBG1 hemoglobin, gamma A 2.1243
NLRP2B NLR family pyrin domain containing 2B 2.1236
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 2.1219
HBQ1 hemoglobin, theta 1 2.11555
SH2D2A SH2 domain containing 2A 2.11175
ARHGAP4 Rho GTPase activating protein 4 2.11075
POLR1A polymerase (RNA) I polypeptide A, 194kDa 2.1083
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.10605
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.10335
ZBTB7B zinc finger and BTB domain containing 7B 2.10305
CLDN15 claudin 15 2.09775
EML2 echinoderm microtubule associated protein like 2 2.09707
MTRF1 mitochondrial translational release factor 1 2.0872
FKTN fukutin 2.08605
MELTF melanotransferrin 2.08595
GDF2 growth differentiation factor 2 2.0847
CAAP1 caspase activity and apoptosis inhibitor 1 2.07755
MORC2 MORC family CW-type zinc finger 2 2.07385
DYNLT1 dynein, light chain, Tctex-type 1 2.07165
EHF ets homologous factor 2.07035
STAT4 signal transducer and activator of transcription 4 2.0632
BABAM1 BRISC and BRCA1 A complex member 1 2.0582
PORCN porcupine homolog (Drosophila) 2.0567
PAQR3 progestin and adipoQ receptor family member III 2.05285
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.05225
TREM2 triggering receptor expressed on myeloid cells 2 2.04785
TOP3B topoisomerase (DNA) III beta 2.04745
AHSP alpha hemoglobin stabilizing protein 2.0461
MRPS2 mitochondrial ribosomal protein S2 2.04135
CRCT1 cysteine-rich C-terminal 1 2.03785
HDDC2 HD domain containing 2 2.03065
ZDHHC6 zinc finger, DHHC-type containing 6 2.0301
GALE UDP-galactose-4-epimerase 2.02785
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.02575
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.02467
TLR3 toll-like receptor 3 2.01805
TMEM267 transmembrane protein 267 2.0121
CXCL11 chemokine (C-X-C motif) ligand 11 2.01205
ANKRD36C ankyrin repeat domain 36C 2.0102
PIGR polymeric immunoglobulin receptor 2.00765
NDEL1 nudE neurodevelopment protein 1-like 1 2.00725
OPTN optineurin 2.00708
PEX7 peroxisomal biogenesis factor 7 2.00585
DCTD dCMP deaminase 2.00358
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.00195

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -8.10025
CCNB2 cyclin B2 -8.08985
THAP11 THAP domain containing 11 -6.8298
FAIM Fas apoptotic inhibitory molecule -6.82035
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -6.6992
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.69725
OXA1L oxidase (cytochrome c) assembly 1-like -6.07985
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -5.6641
ACAA1 acetyl-CoA acyltransferase 1 -5.65857
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.339
PCCB propionyl CoA carboxylase, beta polypeptide -5.228
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.18935
TSPAN4 tetraspanin 4 -5.1231
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.6949
ZW10 zw10 kinetochore protein -4.64315
TM9SF3 transmembrane 9 superfamily member 3 -3.73255
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -3.72795
MTFR1 mitochondrial fission regulator 1 -3.66535
CCDC86 coiled-coil domain containing 86 -3.42275
USP22 ubiquitin specific peptidase 22 -3.29563
NUP93 nucleoporin 93kDa -3.2661
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -3.2374
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.01435
NLRP4 NLR family, pyrin domain containing 4 -2.93335
CCNH cyclin H -2.9284
CCNB1 cyclin B1 -2.9131
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.86035
IGFBP7 insulin-like growth factor binding protein 7 -2.84457
ILK integrin-linked kinase -2.75435
EBNA1BP2 EBNA1 binding protein 2 -2.7495
NGRN neugrin, neurite outgrowth associated -2.74005
HAT1 histone acetyltransferase 1 -2.71825
VANGL1 VANGL planar cell polarity protein 1 -2.6676
TM9SF2 transmembrane 9 superfamily member 2 -2.66715
PTTG1IP pituitary tumor-transforming 1 interacting protein -2.662
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.66155
EPM2AIP1 EPM2A (laforin) interacting protein 1 -2.63045
CTSD cathepsin D -2.6049
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.5346
LRRC41 leucine rich repeat containing 41 -2.50603
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.50467
TBPL1 TBP-like 1 -2.4982
GLOD4 glyoxalase domain containing 4 -2.493
HSPA8 heat shock 70kDa protein 8 -2.47878
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase -2.4778
SCAND1 SCAN domain containing 1 -2.47335
PRCP prolylcarboxypeptidase (angiotensinase C) -2.44965
TXNDC9 thioredoxin domain containing 9 -2.4417
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -2.38165
PTDSS1 phosphatidylserine synthase 1 -2.38055
TLR4 toll-like receptor 4 -2.37215
CRYZ crystallin, zeta (quinone reductase) -2.357
ANXA7 annexin A7 -2.34797
CD58 CD58 molecule -2.33178
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.32565
GDF15 growth differentiation factor 15 -2.31925
RALY RALY heterogeneous nuclear ribonucleoprotein -2.30295
UBQLN2 ubiquilin 2 -2.29485
ELAC2 elaC ribonuclease Z 2 -2.2687
CDK4 cyclin-dependent kinase 4 -2.26835
VAT1 vesicle amine transport 1 -2.26025
ADRM1 adhesion regulating molecule 1 -2.24695
RPN1 ribophorin I -2.2409
HSPA1A heat shock 70kDa protein 1A -2.231
EPS8 epidermal growth factor receptor pathway substrate 8 -2.2208
TUFM Tu translation elongation factor, mitochondrial -2.2159
BLMH bleomycin hydrolase -2.1963
NFU1 NFU1 iron-sulfur cluster scaffold -2.17395
TRIM8 tripartite motif containing 8 -2.15935
HYOU1 hypoxia up-regulated 1 -2.15395
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.15385
ENOPH1 enolase-phosphatase 1 -2.15065
CPVL carboxypeptidase, vitellogenic-like -2.14215
CFP complement factor properdin -2.12685
SOAT2 sterol O-acyltransferase 2 -2.10643
KIFBP kinesin family binding protein -2.1055
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.10122
LOC128966622 putative protein N-methyltransferase FAM86B2 -2.0977
CADM1 cell adhesion molecule 1 -2.09087
RBFA ribosome binding factor A (putative) -2.0741
C5 complement component 5 -2.072
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa -2.0706
IFT57 intraflagellar transport 57 -2.01985
KATNIP katanin interacting protein -2.0018
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -2.0011