CRCGN008_HEPG2_24H:N05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1-dichloroethane 2.41 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN008_HEPG2_24H:N05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 5.6871
AMDHD2 amidohydrolase domain containing 2 5.1539
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.84075
CDPF1 cysteine-rich, DPF motif domain containing 1 4.7193
PLS1 plastin 1 4.56475
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.47585
GSTZ1 glutathione S-transferase zeta 1 4.2993
ZFP36 ZFP36 ring finger protein 3.7445
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 3.57865
CHN1 chimerin 1 3.41635
NMU neuromedin U 3.2448
LOC122526780 uncharacterized LOC122526780 3.12775
METRN meteorin, glial cell differentiation regulator 3.12545
TBPL1 TBP-like 1 2.75715
KIF20A kinesin family member 20A 2.55095
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.5176
STXBP1 syntaxin binding protein 1 2.47315
TNIP1 TNFAIP3 interacting protein 1 2.3762
PCDHB11 protocadherin beta 11 2.34011
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.2759
EPHA3 EPH receptor A3 2.1793
GATA2 GATA binding protein 2 2.1504
BIRC2 baculoviral IAP repeat containing 2 2.1275
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.11985
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.0992
FOS FBJ murine osteosarcoma viral oncogene homolog 2.08745
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.02775

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -5.3768
PCCB propionyl CoA carboxylase, beta polypeptide -5.228
LOC124907782 dual specificity protein phosphatase 22 -5.2225
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.68015
LDHD lactate dehydrogenase D -4.61905
CTSD cathepsin D -4.4982
HLA-DMA major histocompatibility complex, class II, DM alpha -4.42515
CCNB2 cyclin B2 -3.48945
SPAG4 sperm associated antigen 4 -3.46205
AURKB aurora kinase B -3.41325
SNX11 sorting nexin 11 -3.05228
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.95365
ZNF586 zinc finger protein 586 -2.79785
RGS2 regulator of G-protein signaling 2 -2.7309
PLA2G15 phospholipase A2, group XV -2.4796
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.37705
S100A3 S100 calcium binding protein A3 -2.17805
NRIP1 nuclear receptor interacting protein 1 -2.16358
HSPA8 heat shock 70kDa protein 8 -2.08722
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 -2.07415
PDHX pyruvate dehydrogenase complex, component X -2.05362
ARR3 arrestin 3, retinal (X-arrestin) -2.049
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -2.03425