CRCGN008_HEPG2_24H:N07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrazinamide 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

112 genes differentially expressed following the CRCGN008_HEPG2_24H:N07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RRAGA Ras-related GTP binding A 6.3157
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.4877
GSTZ1 glutathione S-transferase zeta 1 5.2186
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.0068
MAMLD1 mastermind-like domain containing 1 4.72145
NOTCH1 notch 1 4.6573
STIMATE STIM activating enhancer 4.62785
UBQLN2 ubiquilin 2 4.51385
MOK MOK protein kinase 4.39155
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.2894
EGF epidermal growth factor 4.2119
TXNL4B thioredoxin-like 4B 4.19045
HOXA10 homeobox A10 4.13925
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.13537
ARL4C ADP-ribosylation factor-like 4C 4.07188
HLA-DRA major histocompatibility complex, class II, DR alpha 3.81573
GPER1 G protein-coupled estrogen receptor 1 3.57998
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.21607
TBPL1 TBP-like 1 3.1629
CYCS cytochrome c, somatic 3.12015
TIAM1 T-cell lymphoma invasion and metastasis 1 3.0994
CCNA1 cyclin A1 3.04945
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.90655
STK10 serine/threonine kinase 10 2.85995
LRRC42 leucine rich repeat containing 42 2.80565
ZNF589 zinc finger protein 589 2.78677
VGLL4 vestigial-like family member 4 2.69858
LPAR2 lysophosphatidic acid receptor 2 2.67878
MORC3 MORC family CW-type zinc finger 3 2.5998
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.48375
LUC7L LUC7-like (S. cerevisiae) 2.33515
OSR2 odd-skipped related transciption factor 2 2.3019
KIF5C kinesin family member 5C 2.27275
ZFAND3 zinc finger, AN1-type domain 3 2.2685
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 2.1809
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 2.1393
PANX1 pannexin 1 2.13115
CREB1 cAMP responsive element binding protein 1 2.11418
BTG3 BTG family, member 3 2.07998
CEP57 centrosomal protein 57kDa 2.07337
PHLDA2 pleckstrin homology-like domain, family A, member 2 2.06795
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2.06265
ZNF232 zinc finger protein 232 2.0583
NOD2 nucleotide-binding oligomerization domain containing 2 2.03265

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.4839
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.55855
OXA1L oxidase (cytochrome c) assembly 1-like -6.13785
MRPS2 mitochondrial ribosomal protein S2 -5.7338
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -5.4946
CHMP4B charged multivesicular body protein 4B -4.91432
LDHD lactate dehydrogenase D -4.7957
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.79555
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -4.5266
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.3724
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.20565
AKAP8 A kinase (PRKA) anchor protein 8 -4.06362
GNAS GNAS complex locus -4.0398
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.0022
SLC35F2 solute carrier family 35, member F2 -3.8809
FGFR4 fibroblast growth factor receptor 4 -3.8686
OSMR oncostatin M receptor -3.1333
ACAA1 acetyl-CoA acyltransferase 1 -3.06983
COPS7A COP9 signalosome subunit 7A -3.04825
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -3.03145
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.65975
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.6419
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.5343
TRADD TNFRSF1A-associated via death domain -2.49118
PRPF4 pre-mRNA processing factor 4 -2.47857
EXOC3 exocyst complex component 3 -2.44895
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) -2.4102
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.4038
RUVBL2 RuvB-like AAA ATPase 2 -2.34475
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -2.3385
CDK17 cyclin-dependent kinase 17 -2.33713
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.32025
RBM34 RNA binding motif protein 34 -2.32007
RAB11FIP5 RAB11 family interacting protein 5 (class I) -2.31305
YJU2 YJU2 splicing factor homolog -2.29855
LYPD3 LY6/PLAUR domain containing 3 -2.29815
RPL36AL ribosomal protein L36a-like -2.2882
IFT22 intraflagellar transport 22 -2.2481
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) -2.23125
CCR6 chemokine (C-C motif) receptor 6 -2.2299
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.2212
SYCP1 synaptonemal complex protein 1 -2.21775
SKIL SKI-like proto-oncogene -2.2094
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -2.18075
HSPA6 heat shock 70kDa protein 6 (HSP70B') -2.18065
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -2.17891
NGLY1 N-glycanase 1 -2.16255
ACTL7B actin-like 7B -2.15845
NPTX2 neuronal pentraxin II -2.1541
BRAF B-Raf proto-oncogene, serine/threonine kinase -2.15175
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 -2.13105
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 -2.11775
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -2.1133
KRT33A keratin 33A, type I -2.11285
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -2.10615
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -2.0975
SFTPD surfactant protein D -2.0835
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.0815
ELAVL2 ELAV like neuron-specific RNA binding protein 2 -2.06235
ZNF365 zinc finger protein 365 -2.05975
FNDC8 fibronectin type III domain containing 8 -2.04845
PLXNA2 plexin A2 -2.0375
POU2AF1 POU class 2 associating factor 1 -2.0355
NRIP3 nuclear receptor interacting protein 3 -2.0307
TEX14 testis expressed 14 -2.0137
PYGO1 pygopus family PHD finger 1 -2.0114
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 -2.01095
CORO2B coronin, actin binding protein, 2B -2.00715