CRCGN008_HEPG2_24H:N09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrazinamide 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN008_HEPG2_24H:N09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LOC122526780 uncharacterized LOC122526780 5.0605
ADRB2 adrenoceptor beta 2, surface 4.85545
CNPY3 canopy FGF signaling regulator 3 4.8061
CBR1 carbonyl reductase 1 4.57625
NOTCH1 notch 1 4.41135
HEBP1 heme binding protein 1 4.1727
HLA-DRA major histocompatibility complex, class II, DR alpha 4.10927
UBE2A ubiquitin-conjugating enzyme E2A 3.46855
EVL Enah/Vasp-like 3.2653
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.81992
CCDC85B coiled-coil domain containing 85B 2.7198
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.67195
JADE2 jade family PHD finger 2 2.56438
CYCS cytochrome c, somatic 2.38
FOS FBJ murine osteosarcoma viral oncogene homolog 2.3187
ADAT1 adenosine deaminase, tRNA-specific 1 2.27285
TIAM1 T-cell lymphoma invasion and metastasis 1 2.24152
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.1554
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.1513
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.08957
BPHL biphenyl hydrolase-like (serine hydrolase) 2.0484
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 2.03395
LPAR2 lysophosphatidic acid receptor 2 2.03163

decreased expression

Symbol Name Standardized Value
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -5.79775
VAT1 vesicle amine transport 1 -5.46395
CHMP4B charged multivesicular body protein 4B -5.12173
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.95355
TLCD3A TLC domain containing 3A -4.7492
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.61145
LDHD lactate dehydrogenase D -4.5919
FGFR4 fibroblast growth factor receptor 4 -4.28982
HLA-DMA major histocompatibility complex, class II, DM alpha -4.07785
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.02835
ANKRD10 ankyrin repeat domain 10 -3.62895
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.4368
PECR peroxisomal trans-2-enoyl-CoA reductase -3.294
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.06207
FHL2 four and a half LIM domains 2 -2.9171
MTA1 metastasis associated 1 -2.9014
OXA1L oxidase (cytochrome c) assembly 1-like -2.88905
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.71873
NRIP1 nuclear receptor interacting protein 1 -2.58765
PRMT7 protein arginine methyltransferase 7 -2.5164
CASC3 cancer susceptibility candidate 3 -2.49405
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.24955
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.24015
PINLYP phospholipase A2 inhibitor and LY6/PLAUR domain containing -2.20485
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.18815
TRAPPC2L trafficking protein particle complex 2-like -2.16755
ARHGAP4 Rho GTPase activating protein 4 -2.0561
USP6NL USP6 N-terminal like -2.0381
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.0148
CLCN3 chloride channel, voltage-sensitive 3 -2.00953