| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | pyrazinamide 4.95 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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78 genes differentially expressed following the CRCGN008_HEPG2_24H:N10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYLK | myosin light chain kinase | 10.0 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 8.3345 |
| CCL2 | chemokine (C-C motif) ligand 2 | 6.452 |
| PPARG | peroxisome proliferator-activated receptor gamma | 5.15985 |
| UBQLN2 | ubiquilin 2 | 5.08685 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 5.049 |
| CBR3 | carbonyl reductase 3 | 4.74435 |
| ADRB2 | adrenoceptor beta 2, surface | 4.60965 |
| PRR15L | proline rich 15-like | 4.5675 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 4.4389 |
| GSTZ1 | glutathione S-transferase zeta 1 | 4.2261 |
| PLSCR1 | phospholipid scramblase 1 | 4.1982 |
| SSBP2 | single-stranded DNA binding protein 2 | 4.155 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 3.93845 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.90145 |
| TBPL1 | TBP-like 1 | 3.8897 |
| EGF | epidermal growth factor | 3.7655 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 3.74868 |
| CYCS | cytochrome c, somatic | 3.4156 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.40798 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 3.0465 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 3.0423 |
| SHB | Src homology 2 domain containing adaptor protein B | 2.97285 |
| PLSCR3 | phospholipid scramblase 3 | 2.7171 |
| CCNF | cyclin F | 2.68375 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | 2.63025 |
| RPL39L | ribosomal protein L39-like | 2.61145 |
| SLBP | stem-loop binding protein | 2.44965 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 2.39493 |
| CSAD | cysteine sulfinic acid decarboxylase | 2.36 |
| CHN1 | chimerin 1 | 2.3008 |
| CTSB | cathepsin B | 2.29445 |
| KIAA0232 | KIAA0232 | 2.28395 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 2.24925 |
| WWC2 | WW and C2 domain containing 2 | 2.1711 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 2.1511 |
| CCNG2 | cyclin G2 | 2.09335 |
| CDCA4 | cell division cycle associated 4 | 2.0571 |
| COX7B | cytochrome c oxidase subunit VIIb | 2.02675 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 2.0071 |
| Symbol | Name | Standardized Value |
|---|---|---|
| OXA1L | oxidase (cytochrome c) assembly 1-like | -6.4886 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -5.4147 |
| CHMP4B | charged multivesicular body protein 4B | -5.04345 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -4.8886 |
| LDHD | lactate dehydrogenase D | -4.8838 |
| DNM1L | dynamin 1-like | -4.85195 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -4.84447 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -4.7732 |
| SCAND1 | SCAN domain containing 1 | -4.64945 |
| GOLT1B | golgi transport 1B | -4.36115 |
| TLCD3A | TLC domain containing 3A | -4.2819 |
| CCNB2 | cyclin B2 | -4.26705 |
| NVL | nuclear VCP-like | -4.1859 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.9285 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.25703 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -3.13935 |
| SESN1 | sestrin 1 | -2.98105 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -2.86525 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -2.77255 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.75607 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.5983 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -2.4901 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.42773 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | -2.41655 |
| RBM34 | RNA binding motif protein 34 | -2.27878 |
| CHP2 | calcineurin-like EF-hand protein 2 | -2.2783 |
| UBE2Q1 | ubiquitin-conjugating enzyme E2Q family member 1 | -2.25915 |
| CLIC4 | chloride intracellular channel 4 | -2.24502 |
| SLC4A2 | solute carrier family 4 (anion exchanger), member 2 | -2.215 |
| HSPA8 | heat shock 70kDa protein 8 | -2.21347 |
| PRTN3 | proteinase 3 | -2.1959 |
| TLR4 | toll-like receptor 4 | -2.17915 |
| RNF167 | ring finger protein 167 | -2.16965 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -2.15613 |
| FZD10 | frizzled class receptor 10 | -2.1178 |
| GDF10 | growth differentiation factor 10 | -2.0668 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | -2.0403 |
| VIPR1 | vasoactive intestinal peptide receptor 1 | -2.0315 |
