CRCGN008_HEPG2_24H:N12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrazinamide 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

133 genes differentially expressed following the CRCGN008_HEPG2_24H:N12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BACE2 beta-site APP-cleaving enzyme 2 10.0
CHN1 chimerin 1 7.06015
TAC4 tachykinin 4 (hemokinin) 5.8829
ABHD4 abhydrolase domain containing 4 5.45875
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.23535
HLA-DMA major histocompatibility complex, class II, DM alpha 5.16555
PPARG peroxisome proliferator-activated receptor gamma 5.12765
MAMLD1 mastermind-like domain containing 1 5.0
MSRA methionine sulfoxide reductase A 4.98465
FZD7 frizzled class receptor 7 4.85997
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.8067
SYNE2 spectrin repeat containing, nuclear envelope 2 4.77025
E2F2 E2F transcription factor 2 4.68435
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.65285
IDE insulin-degrading enzyme 4.43223
HLA-DRA major histocompatibility complex, class II, DR alpha 4.33735
KIF5C kinesin family member 5C 4.2502
PEX11A peroxisomal biogenesis factor 11 alpha 4.22988
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.2041
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 4.13515
SNAP25 synaptosomal-associated protein, 25kDa 4.08045
EGF epidermal growth factor 3.88965
MAP7 microtubule-associated protein 7 3.63073
CYCS cytochrome c, somatic 3.3588
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.28315
TBP TATA box binding protein 3.193
EVL Enah/Vasp-like 3.17395
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.88722
LCN2 lipocalin 2 2.77025
ADAT1 adenosine deaminase, tRNA-specific 1 2.7652
GLDC glycine dehydrogenase (decarboxylating) 2.7144
LGALSL lectin, galactoside-binding-like 2.63015
ZFYVE21 zinc finger, FYVE domain containing 21 2.62225
CHEK2 checkpoint kinase 2 2.60255
PEX3 peroxisomal biogenesis factor 3 2.58818
ARID4A AT rich interactive domain 4A (RBP1-like) 2.5392
SLC25A38 solute carrier family 25, member 38 2.39975
VRK1 vaccinia related kinase 1 2.3463
CHL1 cell adhesion molecule L1-like 2.3347
AHR aryl hydrocarbon receptor 2.3331
ECHDC1 ethylmalonyl-CoA decarboxylase 1 2.3122
GCA grancalcin, EF-hand calcium binding protein 2.30355
TMEM242 transmembrane protein 242 2.2735
IL33 interleukin 33 2.27055
LORICRIN loricrin cornified envelope precursor protein 2.2698
ZNF26 zinc finger protein 26 2.2673
SCYL2 SCY1-like 2 (S. cerevisiae) 2.25565
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 2.253
PKDREJ polycystin (PKD) family receptor for egg jelly 2.24795
HOXB9 homeobox B9 2.2472
VPS9D1 VPS9 domain containing 1 2.2358
WDTC1 WD and tetratricopeptide repeats 1 2.2232
KLHDC8A kelch domain containing 8A 2.2202
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.2019
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.1904
MAPK1 mitogen-activated protein kinase 1 2.1846
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.16445
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) 2.1631
BANK1 B-cell scaffold protein with ankyrin repeats 1 2.15345
EPHA3 EPH receptor A3 2.14793
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.13663
TMEM134 transmembrane protein 134 2.1308
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 2.1243
ATP8B4 ATPase, class I, type 8B, member 4 2.11865
SOCS2 suppressor of cytokine signaling 2 2.09685
UBXN8 UBX domain protein 8 2.06985
KIF17 kinesin family member 17 2.0638
UNG uracil-DNA glycosylase 2.0598
MATN2 matrilin 2 2.0586
PPP1R9A protein phosphatase 1, regulatory subunit 9A 2.05805
BMP2 bone morphogenetic protein 2 2.05048
DMAP1 DNA methyltransferase 1 associated protein 1 2.04305
MRS2 MRS2 magnesium transporter 2.03055
LACTB2 lactamase, beta 2 2.02445
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.0226
USP6NL USP6 N-terminal like 2.02215
LCE2B late cornified envelope 2B 2.0178
ITK IL2-inducible T-cell kinase 2.0049
CRYBG3 beta-gamma crystallin domain containing 3 2.0018

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.5697
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.04085
UGDH UDP-glucose 6-dehydrogenase -5.36215
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.10925
ELAC2 elaC ribonuclease Z 2 -4.8159
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.4273
ZMIZ1 zinc finger, MIZ-type containing 1 -4.3662
GNAS GNAS complex locus -3.97481
CCNB2 cyclin B2 -3.5737
RHEB Ras homolog enriched in brain -3.2935
SPAG4 sperm associated antigen 4 -3.2676
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.08817
CCNB1 cyclin B1 -3.0124
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.91545
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.9111
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.7246
PLXND1 plexin D1 -2.68498
ST14 suppression of tumorigenicity 14 (colon carcinoma) -2.60162
CST2 cystatin SA -2.579
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.57895
YEATS2 YEATS domain containing 2 -2.5453
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 -2.5011
CST1 cystatin SN -2.39035
EFNA1 ephrin-A1 -2.37055
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -2.32095
TM9SF2 transmembrane 9 superfamily member 2 -2.3188
APOC3 apolipoprotein C-III -2.29715
CASC3 cancer susceptibility candidate 3 -2.2798
PCGF3 polycomb group ring finger 3 -2.24502
H1-2 H1.2 linker histone, cluster member -2.2425
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -2.2379
ZFTA zinc finger translocation associated -2.23785
APOB apolipoprotein B -2.2231
RNF115 ring finger protein 115 -2.21035
ORM1 orosomucoid 1 -2.1866
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -2.18655
FGG fibrinogen gamma chain -2.1575
VTN vitronectin -2.14635
FOS FBJ murine osteosarcoma viral oncogene homolog -2.1388
ADAR adenosine deaminase, RNA-specific -2.13085
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -2.12095
ORM2 orosomucoid 2 -2.11825
FOXA2 forkhead box A2 -2.10287
GREM2 gremlin 2, DAN family BMP antagonist -2.09505
CERS2 ceramide synthase 2 -2.09455
ASPN asporin -2.07415
APOA2 apolipoprotein A-II -2.05958
LAMP3 lysosomal-associated membrane protein 3 -2.05945
CIAO3 cytosolic iron-sulfur assembly component 3 -2.0573
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 -2.04688
PIAS3 protein inhibitor of activated STAT, 3 -2.04105
USP1 ubiquitin specific peptidase 1 -2.03605
IFNAR1 interferon (alpha, beta and omega) receptor 1 -2.0317
PTMS parathymosin -2.0153