CRCGN008_HEPG2_24H:N13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fluconazole 20.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN008_HEPG2_24H:N13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 5.793
PPARG peroxisome proliferator-activated receptor gamma 5.6098
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.53705
NOTCH1 notch 1 4.704
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.7021
NMU neuromedin U 4.66275
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.5791
ANO1 anoctamin 1, calcium activated chloride channel 4.251
CCL2 chemokine (C-C motif) ligand 2 4.119
HEBP1 heme binding protein 1 3.77525
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.60434
PTK2 protein tyrosine kinase 2 3.43625
CCNA1 cyclin A1 3.3289
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.26593
PLSCR3 phospholipid scramblase 3 3.16453
TBP TATA box binding protein 3.0284
RRAGA Ras-related GTP binding A 2.9565
JADE2 jade family PHD finger 2 2.82232
SLC75A1 solute carrier family 75 member 1 2.70915
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.5217
RPA3 replication protein A3, 14kDa 2.43915
MAP7 microtubule-associated protein 7 2.43765
COX7B cytochrome c oxidase subunit VIIb 2.42545
PPP6R1 protein phosphatase 6, regulatory subunit 1 2.3094
CYCS cytochrome c, somatic 2.29995
ZNF589 zinc finger protein 589 2.2691
EPHA3 EPH receptor A3 2.1249
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.08325
SCUBE2 signal peptide, CUB domain, EGF-like 2 2.0526
COPS7A COP9 signalosome subunit 7A 2.0414
TTLL12 tubulin tyrosine ligase-like family member 12 2.0408
UBQLN2 ubiquilin 2 2.0283
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 2.02715
TFB2M transcription factor B2, mitochondrial 2.02645
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.01905
REXO5 RNA exonuclease 5 2.01397

decreased expression

Symbol Name Standardized Value
FBXL12 F-box and leucine-rich repeat protein 12 -7.3963
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.7354
OXA1L oxidase (cytochrome c) assembly 1-like -5.71835
TSPAN4 tetraspanin 4 -5.13002
TRIB3 tribbles pseudokinase 3 -5.0804
VAT1 vesicle amine transport 1 -4.90835
NRIP1 nuclear receptor interacting protein 1 -4.80955
ADI1 acireductone dioxygenase 1 -4.7034
LDHD lactate dehydrogenase D -4.6794
CCNB1 cyclin B1 -4.36075
HLA-DMA major histocompatibility complex, class II, DM alpha -4.2913
MAPK13 mitogen-activated protein kinase 13 -3.7626
GLOD4 glyoxalase domain containing 4 -3.695
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.6935
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.10345
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.70205
AKAP8 A kinase (PRKA) anchor protein 8 -2.65737
PLA2G15 phospholipase A2, group XV -2.6047
ITGB1BP1 integrin beta 1 binding protein 1 -2.53955
CSTA cystatin A (stefin A) -2.4309
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -2.13345
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.12315
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.0291