CRCGN008_HEPG2_24H:N15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fluconazole 5.22 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN008_HEPG2_24H:N15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SRC SRC proto-oncogene, non-receptor tyrosine kinase 5.61505
MYLK myosin light chain kinase 5.5972
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 5.43775
CHMP6 charged multivesicular body protein 6 5.38345
SMIM40 small integral membrane protein 40 4.8883
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.7021
E2F2 E2F transcription factor 2 4.61845
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.50582
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.48405
IDE insulin-degrading enzyme 4.38603
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 4.1285
CCNA1 cyclin A1 4.0011
SNAP25 synaptosomal-associated protein, 25kDa 3.8933
PRR15L proline rich 15-like 3.755
MAP7 microtubule-associated protein 7 3.54123
ZNF510 zinc finger protein 510 2.92145
GPATCH8 G patch domain containing 8 2.79253
KIF13B kinesin family member 13B 2.7133
WDTC1 WD and tetratricopeptide repeats 1 2.53663
PPP1R8 protein phosphatase 1, regulatory subunit 8 2.4733
POU2F1 POU class 2 homeobox 1 2.3725
KPLCE KPRP N-terminal and LCE C-terminal like protein 2.3661
SCYL2 SCY1-like 2 (S. cerevisiae) 2.35025
CYCS cytochrome c, somatic 2.3021
LCE2B late cornified envelope 2B 2.2853
TXNL4B thioredoxin-like 4B 2.24465
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.22745
THEMIS2 thymocyte selection associated family member 2 2.19553
LGALSL lectin, galactoside-binding-like 2.1883
DHDDS dehydrodolichyl diphosphate synthase 2.10372
TLR4 toll-like receptor 4 2.1016
KRT2 keratin 2, type II 2.0888
TSHB thyroid stimulating hormone, beta 2.0806
PF4 platelet factor 4 2.0699
DSG1 desmoglein 1 2.0522
RAB25 RAB25, member RAS oncogene family 2.04975
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 2.03365
DMTF1 cyclin D binding myb-like transcription factor 1 2.03073
SLC66A2 solute carrier family 66 member 2 2.0251
GTPBP2 GTP binding protein 2 2.00605

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.31565
CCNB2 cyclin B2 -5.0601
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.9253
ADI1 acireductone dioxygenase 1 -4.89795
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.7517
CCDC86 coiled-coil domain containing 86 -4.71245
DNM1L dynamin 1-like -4.62345
CD320 CD320 molecule -4.52265
FGFR4 fibroblast growth factor receptor 4 -3.71173
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.5563
VDAC1 voltage-dependent anion channel 1 -3.34377
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.05515
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.88
TXNDC9 thioredoxin domain containing 9 -2.77572
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.68885
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.42875
HSPA8 heat shock 70kDa protein 8 -2.24545
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.2331
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.17435
PRSS21 protease, serine, 21 (testisin) -2.13775
RAB3A RAB3A, member RAS oncogene family -2.0502