| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | fluconazole 2.61 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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114 genes differentially expressed following the CRCGN008_HEPG2_24H:N16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CYCS | cytochrome c, somatic | 6.03975 |
| CBR3 | carbonyl reductase 3 | 5.45615 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 5.42553 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 5.2904 |
| EPN2 | epsin 2 | 5.08935 |
| ZFP36 | ZFP36 ring finger protein | 4.27545 |
| CNPY3 | canopy FGF signaling regulator 3 | 4.0122 |
| HEBP1 | heme binding protein 1 | 3.80775 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.79373 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 3.57295 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 3.49655 |
| PLSCR1 | phospholipid scramblase 1 | 3.46335 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.41212 |
| CEP57 | centrosomal protein 57kDa | 3.3942 |
| NOSIP | nitric oxide synthase interacting protein | 3.39005 |
| RPA3 | replication protein A3, 14kDa | 2.9808 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.9001 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 2.72765 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 2.69135 |
| CDK4 | cyclin-dependent kinase 4 | 2.5243 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 2.4671 |
| HIKESHI | heat shock protein nuclear import factor hikeshi | 2.46505 |
| GPATCH8 | G patch domain containing 8 | 2.43128 |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) | 2.40482 |
| DCTPP1 | dCTP pyrophosphatase 1 | 2.36375 |
| AEBP1 | AE binding protein 1 | 2.3174 |
| ZCCHC10 | zinc finger, CCHC domain containing 10 | 2.28535 |
| CCDC106 | coiled-coil domain containing 106 | 2.2812 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 2.28065 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 2.26885 |
| PLSCR4 | phospholipid scramblase 4 | 2.2598 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.25345 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 2.2532 |
| TMEM160 | transmembrane protein 160 | 2.2529 |
| ZNF267 | zinc finger protein 267 | 2.23025 |
| TMEM267 | transmembrane protein 267 | 2.2084 |
| UST | uronyl-2-sulfotransferase | 2.20202 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 2.20105 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 2.2002 |
| TMEM100 | transmembrane protein 100 | 2.1796 |
| UPP1 | uridine phosphorylase 1 | 2.1782 |
| BATF3 | basic leucine zipper transcription factor, ATF-like 3 | 2.17615 |
| KBTBD4 | kelch repeat and BTB (POZ) domain containing 4 | 2.17487 |
| AATF | apoptosis antagonizing transcription factor | 2.16145 |
| TOM1L1 | target of myb1 (chicken)-like 1 | 2.1364 |
| DMXL1 | Dmx-like 1 | 2.13525 |
| IRF7 | interferon regulatory factor 7 | 2.1303 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | 2.12535 |
| MRPS18A | mitochondrial ribosomal protein S18A | 2.1199 |
| CRIPT | cysteine-rich PDZ-binding protein | 2.11915 |
| OBI1 | ORC ubiquitin ligase 1 | 2.099 |
| WDTC1 | WD and tetratricopeptide repeats 1 | 2.09125 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.08277 |
| BMP6 | bone morphogenetic protein 6 | 2.0827 |
| TMEM14A | transmembrane protein 14A | 2.0559 |
| VAMP8 | vesicle-associated membrane protein 8 | 2.0449 |
| SP2 | Sp2 transcription factor | 2.03105 |
| ARHGEF5 | Rho guanine nucleotide exchange factor (GEF) 5 | 2.0309 |
| PRR13 | proline rich 13 | 2.02655 |
| NAMPT | nicotinamide phosphoribosyltransferase | 2.0231 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GNAS | GNAS complex locus | -7.66096 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -6.1947 |
| DNM1L | dynamin 1-like | -5.56355 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.21825 |
| TLCD3A | TLC domain containing 3A | -5.1205 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -5.0481 |
| PCNA | proliferating cell nuclear antigen | -4.81965 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.74225 |
| CCNB2 | cyclin B2 | -4.7368 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.4802 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.3705 |
| DERA | deoxyribose-phosphate aldolase (putative) | -4.22935 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.81 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.52975 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -3.52115 |
| NELFCD | negative elongation factor complex member C/D | -3.1202 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -3.11343 |
| RPN2 | ribophorin II | -3.0289 |
| SESN1 | sestrin 1 | -2.86305 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.82573 |
| BLCAP | bladder cancer associated protein | -2.68165 |
| PLEKHM2 | pleckstrin homology domain containing, family M (with RUN domain) member 2 | -2.57275 |
| TBX2 | T-box 2 | -2.56738 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | -2.5522 |
| PRPF4 | pre-mRNA processing factor 4 | -2.53188 |
| NVL | nuclear VCP-like | -2.5292 |
| ITPKB | inositol-trisphosphate 3-kinase B | -2.4806 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | -2.40865 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.40525 |
| FHL2 | four and a half LIM domains 2 | -2.40195 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.3143 |
| CUL1 | cullin 1 | -2.3094 |
| CDC25B | cell division cycle 25B | -2.26675 |
| ZNF76 | zinc finger protein 76 | -2.2517 |
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | -2.2423 |
| ZNF692 | zinc finger protein 692 | -2.20645 |
| DPP8 | dipeptidyl-peptidase 8 | -2.20425 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -2.15515 |
| MPHOSPH6 | M-phase phosphoprotein 6 | -2.154 |
| MDH1 | malate dehydrogenase 1, NAD (soluble) | -2.15095 |
| SST | somatostatin | -2.14295 |
| FMNL1 | formin-like 1 | -2.13175 |
| SPTBN2 | spectrin, beta, non-erythrocytic 2 | -2.1112 |
| WNT11 | wingless-type MMTV integration site family, member 11 | -2.10915 |
| SMR3A | submaxillary gland androgen regulated protein 3A | -2.1083 |
| BCL2L2 | BCL2-like 2 | -2.10035 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -2.09095 |
| KCNS1 | potassium voltage-gated channel, modifier subfamily S, member 1 | -2.08175 |
| CASC3 | cancer susceptibility candidate 3 | -2.07945 |
| CCNG1 | cyclin G1 | -2.07775 |
| TTC31 | tetratricopeptide repeat domain 31 | -2.06075 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | -2.05395 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | -2.01655 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 | -2.0024 |
