CRCGN008_HEPG2_24H:N18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fluconazole 0.65 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN008_HEPG2_24H:N18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 5.03485
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.8958
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.88965
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.40195
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.38992
SNAP25 synaptosomal-associated protein, 25kDa 4.05802
CHN1 chimerin 1 3.88745
HLA-DRA major histocompatibility complex, class II, DR alpha 3.758
ADAT1 adenosine deaminase, tRNA-specific 1 3.5947
RRAGA Ras-related GTP binding A 3.1326
ANO1 anoctamin 1, calcium activated chloride channel 3.00755
CDK19 cyclin-dependent kinase 19 2.98835
TBPL1 TBP-like 1 2.8866
EVL Enah/Vasp-like 2.86435
HEBP1 heme binding protein 1 2.65085
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.5507
JADE2 jade family PHD finger 2 2.38555
GSTO1 glutathione S-transferase omega 1 2.34425
LY86 lymphocyte antigen 86 2.34325
GTF2H5 general transcription factor IIH, polypeptide 5 2.15295
SLC68A1 solute carrier family 68 member 1 2.1264
GNG10 guanine nucleotide binding protein (G protein), gamma 10 2.08445
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 2.05725
MCUR1 mitochondrial calcium uniporter regulator 1 2.0142

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.87155
CCNB2 cyclin B2 -4.7503
HDAC2 histone deacetylase 2 -4.04075
OXA1L oxidase (cytochrome c) assembly 1-like -3.0106
FBXL12 F-box and leucine-rich repeat protein 12 -2.9348
RNF167 ring finger protein 167 -2.56225
SESN1 sestrin 1 -2.4834
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.4189
LGMN legumain -2.3999
OGN osteoglycin -2.3633
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.1181
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.10722
PEG10 paternally expressed 10 -2.07912
MYH9 myosin, heavy chain 9, non-muscle -2.07015
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.05247
FBXO3 F-box protein 3 -2.02155
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.00555
SPDEF SAM pointed domain containing ETS transcription factor -2.00468