CRCGN008_HEPG2_24H:N19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description TCDD-dioxin 50.0 nm perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

141 genes differentially expressed following the CRCGN008_HEPG2_24H:N19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 5.9315
CNPY3 canopy FGF signaling regulator 3 5.3413
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.32035
TIMP2 TIMP metallopeptidase inhibitor 2 5.17655
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 5.10315
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 4.74065
MYLK myosin light chain kinase 4.56035
STIMATE STIM activating enhancer 4.34545
ABHD4 abhydrolase domain containing 4 4.27345
EGF epidermal growth factor 4.2606
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.058
MCM3 minichromosome maintenance complex component 3 3.9206
CCL2 chemokine (C-C motif) ligand 2 3.9161
GPER1 G protein-coupled estrogen receptor 1 3.61615
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.47985
SPDEF SAM pointed domain containing ETS transcription factor 3.47657
SATB1 SATB homeobox 1 3.44935
PPARG peroxisome proliferator-activated receptor gamma 3.42015
HMOX1 heme oxygenase 1 3.33925
CRYZ crystallin, zeta (quinone reductase) 3.2845
NOSIP nitric oxide synthase interacting protein 3.2471
SLC75A1 solute carrier family 75 member 1 3.2386
RAP1GAP RAP1 GTPase activating protein 3.2021
MVP major vault protein 3.188
STAP2 signal transducing adaptor family member 2 3.0504
SQOR sulfide quinone oxidoreductase 3.0319
PMM2 phosphomannomutase 2 3.0241
HEBP1 heme binding protein 1 3.00295
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.8774
MICALL1 MICAL-like 1 2.87675
TXNRD1 thioredoxin reductase 1 2.80215
JADE2 jade family PHD finger 2 2.74825
KLHL9 kelch-like family member 9 2.72538
PLS1 plastin 1 2.68675
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.6776
BPHL biphenyl hydrolase-like (serine hydrolase) 2.64875
EPHA3 EPH receptor A3 2.57412
SSBP2 single-stranded DNA binding protein 2 2.57327
STX18 syntaxin 18 2.51405
TIAM1 T-cell lymphoma invasion and metastasis 1 2.4642
MSX1 msh homeobox 1 2.45975
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.45463
CYCS cytochrome c, somatic 2.4194
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.393
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.3615
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.33285
DYNLT3 dynein, light chain, Tctex-type 3 2.3027
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa 2.30115
MYD88 myeloid differentiation primary response 88 2.2917
ANO1 anoctamin 1, calcium activated chloride channel 2.27675
GPATCH8 G patch domain containing 8 2.2635
CGRRF1 cell growth regulator with ring finger domain 1 2.2559
DTYMK deoxythymidylate kinase (thymidylate kinase) 2.2524
UGDH UDP-glucose 6-dehydrogenase 2.2509
SPON2 spondin 2, extracellular matrix protein 2.24795
SMAD3 SMAD family member 3 2.24554
GSTA4 glutathione S-transferase alpha 4 2.1893
ZXDC ZXD family zinc finger C 2.15445
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 2.13835
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.1234
ZNF589 zinc finger protein 589 2.09062
KIFBP kinesin family binding protein 2.0852
WDR82 WD repeat domain 82 2.07875
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 2.03665
SLIT2 slit homolog 2 (Drosophila) 2.03095
DDAH2 dimethylarginine dimethylaminohydrolase 2 2.0255
EPS8 epidermal growth factor receptor pathway substrate 8 2.0211
PHF11 PHD finger protein 11 2.01045

decreased expression

Symbol Name Standardized Value
THAP11 THAP domain containing 11 -5.85935
ISOC1 isochorismatase domain containing 1 -5.80705
ADI1 acireductone dioxygenase 1 -5.41355
TLCD3A TLC domain containing 3A -5.06885
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0495
LDHD lactate dehydrogenase D -4.94995
PCNA proliferating cell nuclear antigen -4.81965
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.717
PECR peroxisomal trans-2-enoyl-CoA reductase -4.5664
SLC35F2 solute carrier family 35, member F2 -4.4876
MAP7 microtubule-associated protein 7 -4.4463
CCDC86 coiled-coil domain containing 86 -4.04485
REEP5 receptor accessory protein 5 -3.91408
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.5846
FHL2 four and a half LIM domains 2 -3.49865
CLIC4 chloride intracellular channel 4 -3.48505
HSPA8 heat shock 70kDa protein 8 -3.38438
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.3387
PSRC1 proline/serine-rich coiled-coil 1 -3.31805
NGRN neugrin, neurite outgrowth associated -3.24045
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.0835
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -2.86185
MACROD1 MACRO domain containing 1 -2.84905
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.83635
C5 complement component 5 -2.7973
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.78575
AURKB aurora kinase B -2.773
DCLRE1A DNA cross-link repair 1A -2.73825
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.61545
PPME1 protein phosphatase methylesterase 1 -2.5768
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) -2.55625
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.54545
OXA1L oxidase (cytochrome c) assembly 1-like -2.52665
FEN1 flap structure-specific endonuclease 1 -2.437
TRIB3 tribbles pseudokinase 3 -2.38815
KLRC1 killer cell lectin-like receptor subfamily C, member 1 -2.3577
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.3528
HAT1 histone acetyltransferase 1 -2.3421
MCTP2 multiple C2 domains, transmembrane 2 -2.32275
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa -2.3192
CCP110 centriolar coiled coil protein 110kDa -2.30955
TXNDC9 thioredoxin domain containing 9 -2.30837
MSH2 mutS homolog 2 -2.28795
CENPT centromere protein T -2.28075
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.2751
FAT1 FAT atypical cadherin 1 -2.2415
S100A1 S100 calcium binding protein A1 -2.23135
SIPA1L3 signal-induced proliferation-associated 1 like 3 -2.20205
PRPF4 pre-mRNA processing factor 4 -2.1986
NAE1 NEDD8 activating enzyme E1 subunit 1 -2.19505
CKLF-CMTM1 CKLF-CMTM1 readthrough -2.19107
MCM10 minichromosome maintenance complex component 10 -2.17835
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) -2.1678
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 -2.141
ENTR1 endosome associated trafficking regulator 1 -2.13895
NDOR1 NADPH dependent diflavin oxidoreductase 1 -2.13375
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -2.13325
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.12615
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -2.1217
RBM34 RNA binding motif protein 34 -2.11568
PARD6A par-6 family cell polarity regulator alpha -2.0887
PDF peptide deformylase (mitochondrial) -2.08725
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -2.06895
CDC20 cell division cycle 20 -2.06185
SH2D2A SH2 domain containing 2A -2.0508
UPK2 uroplakin 2 -2.03815
MSH6 mutS homolog 6 -2.03513
B3GAT1 beta-1,3-glucuronyltransferase 1 -2.0254
ADORA3 adenosine A3 receptor -2.0152
TTPAL tocopherol (alpha) transfer protein-like -2.01465
INTS3 integrator complex subunit 3 -2.0131
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -2.00949
SIPA1L1 signal-induced proliferation-associated 1 like 1 -2.00047