CRCGN008_HEPG2_24H:N20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description TCDD-dioxin 25.0 nm perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

155 genes differentially expressed following the CRCGN008_HEPG2_24H:N20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 7.1973
ZFP36 ZFP36 ring finger protein 7.10975
VAT1 vesicle amine transport 1 5.7904
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.0179
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.9092
CDPF1 cysteine-rich, DPF motif domain containing 1 4.8865
ADRB2 adrenoceptor beta 2, surface 4.8057
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.79255
NMU neuromedin U 4.75495
MYLK myosin light chain kinase 4.66275
NOTCH1 notch 1 4.59995
HOXA10 homeobox A10 4.59065
C2CD2 C2 calcium-dependent domain containing 2 4.46315
WDTC1 WD and tetratricopeptide repeats 1 4.22362
CNPY3 canopy FGF signaling regulator 3 4.22195
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.2051
PLS1 plastin 1 4.15425
SFTPB surfactant protein B 4.00837
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.74735
UBE2A ubiquitin-conjugating enzyme E2A 3.73
TXNL4B thioredoxin-like 4B 3.6852
GPER1 G protein-coupled estrogen receptor 1 3.67947
TIMP2 TIMP metallopeptidase inhibitor 2 3.64325
MVP major vault protein 3.5887
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 3.5487
ABHD6 abhydrolase domain containing 6 3.47517
HMOX1 heme oxygenase 1 3.28695
RAP1GAP RAP1 GTPase activating protein 3.2607
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.2402
SPDEF SAM pointed domain containing ETS transcription factor 3.23268
CGRRF1 cell growth regulator with ring finger domain 1 3.1873
RAB21 RAB21, member RAS oncogene family 3.13325
SQOR sulfide quinone oxidoreductase 3.08355
VGLL4 vestigial-like family member 4 3.06702
ACOT9 acyl-CoA thioesterase 9 3.0158
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.96373
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.934
CEMIP2 cell migration inducing hyaluronidase 2 2.93315
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.87695
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.86035
SLC75A1 solute carrier family 75 member 1 2.78675
HEBP1 heme binding protein 1 2.7306
TXNRD1 thioredoxin reductase 1 2.7268
EVL Enah/Vasp-like 2.70635
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.68892
MYLIP myosin regulatory light chain interacting protein 2.6825
MEST mesoderm specific transcript 2.67985
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.6663
EPS8 epidermal growth factor receptor pathway substrate 8 2.6502
YBX1 Y box binding protein 1 2.64283
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.6231
UGDH UDP-glucose 6-dehydrogenase 2.57755
PPARG peroxisome proliferator-activated receptor gamma 2.57555
MSX1 msh homeobox 1 2.50675
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.50365
KIF20A kinesin family member 20A 2.49305
NOSIP nitric oxide synthase interacting protein 2.46305
CRYZ crystallin, zeta (quinone reductase) 2.4522
MAP7 microtubule-associated protein 7 2.40873
TNRC6B trinucleotide repeat containing 6B 2.32665
STAP2 signal transducing adaptor family member 2 2.31385
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) 2.3047
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.293
DUSP6 dual specificity phosphatase 6 2.28392
TMEM212 transmembrane protein 212 2.26565
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.23525
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.23035
CAVIN2 caveolae associated protein 2 2.2104
NCOA4 nuclear receptor coactivator 4 2.1856
BCORL1 BCL6 corepressor-like 1 2.179
BYSL bystin-like 2.16735
HAND1 heart and neural crest derivatives expressed 1 2.16655
STXBP2 syntaxin binding protein 2 2.16205
CYCS cytochrome c, somatic 2.13285
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2.13015
RALB v-ral simian leukemia viral oncogene homolog B 2.12975
SNRPC small nuclear ribonucleoprotein polypeptide C 2.11985
REPS2 RALBP1 associated Eps domain containing 2 2.1161
DAZAP1 DAZ associated protein 1 2.10385
CRTAP cartilage associated protein 2.09005
AP5M1 adaptor-related protein complex 5, mu 1 subunit 2.0768
BCL6 B-cell CLL/lymphoma 6 2.05785
CNPPD1 cyclin Pas1/PHO80 domain containing 1 2.05737
NMRK2 nicotinamide riboside kinase 2 2.04995
TLR4 toll-like receptor 4 2.03745
SIAH2 siah E3 ubiquitin protein ligase 2 2.03645
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.02992
CEMP1 cementum protein 1 2.0094
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.0007

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
SLC35F2 solute carrier family 35, member F2 -8.80025
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.7975
LDHD lactate dehydrogenase D -4.7957
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.7416
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -4.00612
FHL2 four and a half LIM domains 2 -3.9874
PECR peroxisomal trans-2-enoyl-CoA reductase -3.8722
ACAA1 acetyl-CoA acyltransferase 1 -3.6508
PSRC1 proline/serine-rich coiled-coil 1 -3.63785
PRPF4 pre-mRNA processing factor 4 -3.52933
PDZD2 PDZ domain containing 2 -3.50315
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -3.29795
ARID5B AT rich interactive domain 5B (MRF1-like) -3.17475
TRIB3 tribbles pseudokinase 3 -3.16265
RGS2 regulator of G-protein signaling 2 -3.11335
OXA1L oxidase (cytochrome c) assembly 1-like -3.06745
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.878
CDK1 cyclin-dependent kinase 1 -2.74988
DHCR7 7-dehydrocholesterol reductase -2.7485
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.72035
CLTB clathrin, light chain B -2.70124
AURKB aurora kinase B -2.6917
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.6464
NCAPD2 non-SMC condensin I complex, subunit D2 -2.64605
IL4R interleukin 4 receptor -2.58235
TXNDC9 thioredoxin domain containing 9 -2.5652
GPATCH2 G patch domain containing 2 -2.54565
SPAG4 sperm associated antigen 4 -2.52075
AKAP8 A kinase (PRKA) anchor protein 8 -2.5063
PARP1 poly (ADP-ribose) polymerase 1 -2.49505
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.46745
SEC63 SEC63 homolog (S. cerevisiae) -2.44127
FBXO46 F-box protein 46 -2.4397
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.37785
CENPS-CORT CENPS-CORT readthrough -2.3751
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.35385
GLRX2 glutaredoxin 2 -2.3524
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.33945
AARS1 alanyl-tRNA synthetase 1 -2.33685
USPL1 ubiquitin specific peptidase like 1 -2.32505
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.31995
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.27058
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.2655
SESN1 sestrin 1 -2.2481
ACLY ATP citrate lyase -2.21432
JMJD4 jumonji domain containing 4 -2.1913
FGFR4 fibroblast growth factor receptor 4 -2.16425
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.16042
TECR trans-2,3-enoyl-CoA reductase -2.1489
TGDS TDP-glucose 4,6-dehydratase -2.12695
PYCR3 pyrroline-5-carboxylate reductase 3 -2.12465
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.1112
CORO2A coronin, actin binding protein, 2A -2.1093
CASP8AP2 caspase 8 associated protein 2 -2.10815
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.1046
HMGA2 high mobility group AT-hook 2 -2.0837
RBBP5 retinoblastoma binding protein 5 -2.0778
ZDHHC6 zinc finger, DHHC-type containing 6 -2.06265
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.05925
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.05755
ASF1B anti-silencing function 1B histone chaperone -2.05475
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) -2.04345
MSH6 mutS homolog 6 -2.03342
USP1 ubiquitin specific peptidase 1 -2.00572
NAT10 N-acetyltransferase 10 (GCN5-related) -2.0048