CRCGN008_HEPG2_24H:N21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description TCDD-dioxin 12.5 nm perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

145 genes differentially expressed following the CRCGN008_HEPG2_24H:N21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 9.67715
VAT1 vesicle amine transport 1 7.23
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 7.06775
PPARG peroxisome proliferator-activated receptor gamma 6.5443
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.23685
MYLK myosin light chain kinase 5.71085
CBR3 carbonyl reductase 3 5.359
EAPP E2F-associated phosphoprotein 5.23935
CHMP6 charged multivesicular body protein 6 5.1694
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.8431
EGF epidermal growth factor 4.8144
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.7101
ATP11B ATPase, class VI, type 11B 4.70625
RRAGA Ras-related GTP binding A 4.462
TIAM1 T-cell lymphoma invasion and metastasis 1 4.24928
SQOR sulfide quinone oxidoreductase 4.24865
MVP major vault protein 4.244
ABHD6 abhydrolase domain containing 6 4.20723
KIFBP kinesin family binding protein 4.04065
SSBP2 single-stranded DNA binding protein 2 3.92102
RAP1GAP RAP1 GTPase activating protein 3.8676
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.8098
BPHL biphenyl hydrolase-like (serine hydrolase) 3.6197
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.60748
LPGAT1 lysophosphatidylglycerol acyltransferase 1 3.51455
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.5126
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.48945
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.38095
TXNRD1 thioredoxin reductase 1 3.31765
ZFP36 ZFP36 ring finger protein 3.2886
NMU neuromedin U 3.2339
HMOX1 heme oxygenase 1 3.19805
SLC75A1 solute carrier family 75 member 1 3.1259
ABHD4 abhydrolase domain containing 4 3.0924
CYB5A cytochrome b5 type A (microsomal) 3.01077
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.0061
HSPA1A heat shock 70kDa protein 1A 2.9962
UGDH UDP-glucose 6-dehydrogenase 2.93715
BAG3 BCL2-associated athanogene 3 2.89175
HEBP1 heme binding protein 1 2.8325
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.80795
SOCS2 suppressor of cytokine signaling 2 2.76432
UBE2A ubiquitin-conjugating enzyme E2A 2.75395
DUSP6 dual specificity phosphatase 6 2.74252
NVL nuclear VCP-like 2.7018
BAMBI BMP and activin membrane-bound inhibitor 2.67005
STAP2 signal transducing adaptor family member 2 2.61655
CGRRF1 cell growth regulator with ring finger domain 1 2.58175
BAX BCL2-associated X protein 2.55268
MINDY1 MINDY lysine 48 deubiquitinase 1 2.51505
KIF20A kinesin family member 20A 2.47555
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.4688
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.4641
SORBS3 sorbin and SH3 domain containing 3 2.4639
CNPY3 canopy FGF signaling regulator 3 2.4259
LRRC42 leucine rich repeat containing 42 2.4155
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.39245
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.38173
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.38078
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.37997
CLIC2 chloride intracellular channel 2 2.37385
ACOT9 acyl-CoA thioesterase 9 2.3492
TMSB15C thymosin beta 15C 2.3356
KAT6A K(lysine) acetyltransferase 6A 2.33105
STX4 syntaxin 4 2.319
LPAR2 lysophosphatidic acid receptor 2 2.27358
CDC25B cell division cycle 25B 2.23325
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.1646
CCL17 chemokine (C-C motif) ligand 17 2.151
RAB21 RAB21, member RAS oncogene family 2.15055
PLS1 plastin 1 2.1492
CD2AP CD2-associated protein 2.13425
GTPBP6 GTP binding protein 6 (putative) 2.13135
TNS2 tensin 2 2.1132
EGLN3 egl-9 family hypoxia-inducible factor 3 2.10155
SLC35A5 solute carrier family 35, member A5 2.10145
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 2.101
MAD2L1BP MAD2L1 binding protein 2.07915
ECD ecdysoneless homolog (Drosophila) 2.077
KRT2 keratin 2, type II 2.0764
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 2.06635
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.0586
TWF2 twinfilin actin binding protein 2 2.0569
RAB1B RAB1B, member RAS oncogene family 2.05595
ANGPTL4 angiopoietin-like 4 2.01605
HMG20B high mobility group 20B 2.00493

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -8.2416
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.82435
OXA1L oxidase (cytochrome c) assembly 1-like -5.77945
NT5DC2 5'-nucleotidase domain containing 2 -5.45325
ZNF586 zinc finger protein 586 -5.2747
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.2507
PCNA proliferating cell nuclear antigen -5.193
ZW10 zw10 kinetochore protein -5.1391
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -4.96908
PECR peroxisomal trans-2-enoyl-CoA reductase -4.87225
BLCAP bladder cancer associated protein -4.80135
USP6NL USP6 N-terminal like -4.72545
LDHD lactate dehydrogenase D -4.4185
CCNB2 cyclin B2 -4.3609
PSRC1 proline/serine-rich coiled-coil 1 -4.31065
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -4.02805
CD58 CD58 molecule -3.46908
CDC20 cell division cycle 20 -3.40545
DDIT4 DNA-damage-inducible transcript 4 -3.34025
GNAS GNAS complex locus -3.32324
NRIP1 nuclear receptor interacting protein 1 -3.11305
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.89085
RBM34 RNA binding motif protein 34 -2.87647
PGM1 phosphoglucomutase 1 -2.728
EGR1 early growth response 1 -2.68537
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.6296
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.5441
DPH2 DPH2 homolog (S. cerevisiae) -2.5081
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.4661
RPL37 ribosomal protein L37 -2.44235
LOC124907782 dual specificity protein phosphatase 22 -2.42465
GMPPA GDP-mannose pyrophosphorylase A -2.4087
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.38715
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.3748
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.36155
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.30982
AURKB aurora kinase B -2.28115
ACAA1 acetyl-CoA acyltransferase 1 -2.248
HYOU1 hypoxia up-regulated 1 -2.2305
CDK1 cyclin-dependent kinase 1 -2.19747
RPS13 ribosomal protein S13 -2.181
TATDN2 TatD DNase domain containing 2 -2.1748
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.17155
BLM Bloom syndrome, RecQ helicase-like -2.16585
IGF2 insulin-like growth factor 2 -2.16272
ALDOC aldolase C, fructose-bisphosphate -2.15785
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.151
CNN2 calponin 2 -2.13555
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.13295
HMGA2 high mobility group AT-hook 2 -2.1213
DSCC1 DNA replication and sister chromatid cohesion 1 -2.105
NOP53 NOP53 ribosome biogenesis factor -2.0957
PM20D1 peptidase M20 domain containing 1 -2.09063
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.08115
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -2.0753
GCSH glycine cleavage system protein H (aminomethyl carrier) -2.05883
TCERG1 transcription elongation regulator 1 -2.01865
REEP5 receptor accessory protein 5 -2.01017
EDN1 endothelin 1 -2.00425