CRCGN008_HEPG2_24H:N22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description TCDD-dioxin 6.25 nm perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

107 genes differentially expressed following the CRCGN008_HEPG2_24H:N22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIMP2 TIMP metallopeptidase inhibitor 2 6.2488
ZFP36 ZFP36 ring finger protein 5.5377
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.04965
ADRB2 adrenoceptor beta 2, surface 4.9265
EPHB2 EPH receptor B2 4.90825
DYNLT3 dynein, light chain, Tctex-type 3 4.7982
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.5648
SQOR sulfide quinone oxidoreductase 4.40575
PLS1 plastin 1 3.8182
TXNRD1 thioredoxin reductase 1 3.7921
GPER1 G protein-coupled estrogen receptor 1 3.77077
HMOX1 heme oxygenase 1 3.5952
RAP1GAP RAP1 GTPase activating protein 3.55135
UGDH UDP-glucose 6-dehydrogenase 3.51375
MVP major vault protein 3.50625
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 3.45555
HEBP1 heme binding protein 1 3.4402
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.43958
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.372
CGRRF1 cell growth regulator with ring finger domain 1 3.2999
PRKCH protein kinase C, eta 3.24175
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.17085
TRIM13 tripartite motif containing 13 3.0608
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.04265
NMU neuromedin U 2.95675
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.81083
SSBP2 single-stranded DNA binding protein 2 2.68345
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.65095
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.63975
DEFA5 defensin, alpha 5, Paneth cell-specific 2.55475
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.552
ACOT9 acyl-CoA thioesterase 9 2.5354
BAG3 BCL2-associated athanogene 3 2.52245
CRYZ crystallin, zeta (quinone reductase) 2.51395
DEFA6 defensin, alpha 6, Paneth cell-specific 2.49885
WFS1 Wolfram syndrome 1 (wolframin) 2.48935
GPATCH8 G patch domain containing 8 2.43575
TGFBI transforming growth factor, beta-induced, 68kDa 2.41645
CHN1 chimerin 1 2.4042
SMAD3 SMAD family member 3 2.3869
PPARG peroxisome proliferator-activated receptor gamma 2.3438
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.32945
TBPL1 TBP-like 1 2.29695
CYTH1 cytohesin 1 2.2938
KIF20A kinesin family member 20A 2.2892
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.2641
SORBS3 sorbin and SH3 domain containing 3 2.257
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 2.25085
TMEM50A transmembrane protein 50A 2.219
ANO10 anoctamin 10 2.1823
MINDY1 MINDY lysine 48 deubiquitinase 1 2.1777
CREG1 cellular repressor of E1A-stimulated genes 1 2.15355
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.1299
SOCS2 suppressor of cytokine signaling 2 2.11538
GCLC glutamate-cysteine ligase, catalytic subunit 2.09623
RSU1 Ras suppressor protein 1 2.09415
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.05685
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 2.0319
STAP2 signal transducing adaptor family member 2 2.0302
COMMD10 COMM domain containing 10 2.0248
RAB21 RAB21, member RAS oncogene family 2.02385
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.02093
WNT8B wingless-type MMTV integration site family, member 8B 2.0057

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -8.1875
LDHD lactate dehydrogenase D -5.0559
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.9602
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.9253
ISOC1 isochorismatase domain containing 1 -4.6769
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.44975
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.2123
PSRC1 proline/serine-rich coiled-coil 1 -4.15875
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -4.12785
CCNB2 cyclin B2 -4.03195
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.72145
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.68345
RGS2 regulator of G-protein signaling 2 -3.5533
C5 complement component 5 -3.506
OXA1L oxidase (cytochrome c) assembly 1-like -3.12405
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.05605
CLTB clathrin, light chain B -2.96114
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.81868
AURKB aurora kinase B -2.60395
TRAPPC8 trafficking protein particle complex 8 -2.55885
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.5527
TXNDC9 thioredoxin domain containing 9 -2.5502
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.44185
SPAG4 sperm associated antigen 4 -2.33255
EGLN1 egl-9 family hypoxia-inducible factor 1 -2.3222
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.30258
CCNA2 cyclin A2 -2.23565
WBP2 WW domain binding protein 2 -2.1977
AARS1 alanyl-tRNA synthetase 1 -2.16215
ALDOC aldolase C, fructose-bisphosphate -2.157
CCL19 chemokine (C-C motif) ligand 19 -2.0913
VAT1 vesicle amine transport 1 -2.0772
ETHE1 ethylmalonic encephalopathy 1 -2.0689
CDK4 cyclin-dependent kinase 4 -2.06815
POLM polymerase (DNA directed), mu -2.05935
SCAP SREBF chaperone -2.04265
SSNA1 Sjogren syndrome nuclear autoantigen 1 -2.04185
DHCR7 7-dehydrocholesterol reductase -2.03995
ACAA1 acetyl-CoA acyltransferase 1 -2.03495
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.0313
MYBBP1A MYB binding protein (P160) 1a -2.0292
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.0231
RNF44 ring finger protein 44 -2.0191
CXCR2 chemokine (C-X-C motif) receptor 2 -2.0137