| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | TCDD-dioxin 3.13 nm perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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143 genes differentially expressed following the CRCGN008_HEPG2_24H:N23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CYCS | cytochrome c, somatic | 6.21 |
| PPARG | peroxisome proliferator-activated receptor gamma | 6.0468 |
| VAT1 | vesicle amine transport 1 | 5.2902 |
| AMDHD2 | amidohydrolase domain containing 2 | 5.0623 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 4.9466 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 4.91525 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 4.73895 |
| CBR3 | carbonyl reductase 3 | 4.66275 |
| EPHB2 | EPH receptor B2 | 4.41515 |
| CCL2 | chemokine (C-C motif) ligand 2 | 4.109 |
| ZFP36 | ZFP36 ring finger protein | 4.09055 |
| EGF | epidermal growth factor | 3.94915 |
| PRR15L | proline rich 15-like | 3.6323 |
| MAP7 | microtubule-associated protein 7 | 3.50465 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.45705 |
| TXNRD1 | thioredoxin reductase 1 | 3.3999 |
| HEBP1 | heme binding protein 1 | 3.0303 |
| ABHD6 | abhydrolase domain containing 6 | 3.00938 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.87548 |
| VGLL4 | vestigial-like family member 4 | 2.74425 |
| PDGFRL | platelet-derived growth factor receptor-like | 2.7193 |
| HSPA1A | heat shock 70kDa protein 1A | 2.7149 |
| TBPL1 | TBP-like 1 | 2.70315 |
| CRIPTO3 | cripto, EGF-CFC family member 3 | 2.69965 |
| VLDLR | very low density lipoprotein receptor | 2.68075 |
| HMOX1 | heme oxygenase 1 | 2.65815 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.60555 |
| ZP2 | zona pellucida glycoprotein 2 (sperm receptor) | 2.56075 |
| RAP1GAP | RAP1 GTPase activating protein | 2.55855 |
| MVP | major vault protein | 2.5515 |
| KIF20A | kinesin family member 20A | 2.54195 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2.4701 |
| CCNP | cyclin P | 2.3964 |
| AARSD1 | alanyl-tRNA synthetase domain containing 1 | 2.3872 |
| GUCY2C | guanylate cyclase 2C | 2.3802 |
| WDR7 | WD repeat domain 7 | 2.32995 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 2.32495 |
| WNT11 | wingless-type MMTV integration site family, member 11 | 2.30595 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 2.29295 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | 2.2907 |
| LOC122526780 | uncharacterized LOC122526780 | 2.2742 |
| PARP2 | poly (ADP-ribose) polymerase 2 | 2.25897 |
| FLOT1 | flotillin 1 | 2.24612 |
| RORC | RAR-related orphan receptor C | 2.23715 |
| BCL2L10 | BCL2-like 10 (apoptosis facilitator) | 2.19875 |
| CLDN3 | claudin 3 | 2.19357 |
| OR10C1 | olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) | 2.1702 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.16445 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | 2.16355 |
| CDX1 | caudal type homeobox 1 | 2.13995 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 2.12955 |
| TFF3 | trefoil factor 3 (intestinal) | 2.11925 |
| CCN5 | cellular communication network factor 5 | 2.1162 |
| NMI | N-myc (and STAT) interactor | 2.1029 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | 2.09365 |
| ADRA2A | adrenoceptor alpha 2A | 2.08725 |
| WASHC3 | WASH complex subunit 3 | 2.08395 |
| COQ8A | coenzyme Q8A | 2.0789 |
| ZNF816 | zinc finger protein 816 | 2.07285 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | 2.07175 |
| CLN6 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | 2.06815 |
| ZNF35 | zinc finger protein 35 | 2.06485 |
| CHRNA3 | cholinergic receptor, nicotinic, alpha 3 (neuronal) | 2.06395 |
| MSX2 | msh homeobox 2 | 2.0527 |
| PIGZ | phosphatidylinositol glycan anchor biosynthesis, class Z | 2.0387 |
| FLNC | filamin C, gamma | 2.02645 |
| GHRH | growth hormone releasing hormone | 2.02305 |
| GPA33 | glycoprotein A33 (transmembrane) | 2.02235 |
| NACAD | NAC alpha domain containing | 2.01525 |
| HDAC11 | histone deacetylase 11 | 2.00865 |
| HAND1 | heart and neural crest derivatives expressed 1 | 2.0085 |
| Symbol | Name | Standardized Value |
|---|---|---|
| C5 | complement component 5 | -6.69355 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -5.90795 |
| GOLT1B | golgi transport 1B | -5.3188 |
| MRPS2 | mitochondrial ribosomal protein S2 | -5.1883 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -5.08605 |
| COG7 | component of oligomeric golgi complex 7 | -5.0 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.5436 |
| PCNA | proliferating cell nuclear antigen | -4.50795 |
| GNAS | GNAS complex locus | -3.81994 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -3.43665 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.32285 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | -3.21105 |
| SLC9A8 | solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 | -3.16625 |
| HMG20B | high mobility group 20B | -3.07247 |
| STMN1 | stathmin 1 | -2.8825 |
| POLR3E | polymerase (RNA) III (DNA directed) polypeptide E (80kD) | -2.7988 |
| PDZD2 | PDZ domain containing 2 | -2.72165 |
| CCP110 | centriolar coiled coil protein 110kDa | -2.62455 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | -2.5427 |
| EGR1 | early growth response 1 | -2.53787 |
| PPP4C | protein phosphatase 4, catalytic subunit | -2.50715 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.4513 |
| INTS3 | integrator complex subunit 3 | -2.41885 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | -2.41685 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -2.4167 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.40355 |
| CSAD | cysteine sulfinic acid decarboxylase | -2.40175 |
| LGMN | legumain | -2.37885 |
| MLF2 | myeloid leukemia factor 2 | -2.361 |
| PMPCA | peptidase (mitochondrial processing) alpha | -2.3564 |
| PLCXD1 | phosphatidylinositol-specific phospholipase C, X domain containing 1 | -2.3543 |
| MAST3 | microtubule associated serine/threonine kinase 3 | -2.3503 |
| ENTR1 | endosome associated trafficking regulator 1 | -2.33545 |
| CMAS | cytidine monophosphate N-acetylneuraminic acid synthetase | -2.2992 |
| MAP9 | microtubule-associated protein 9 | -2.29695 |
| RLIM | ring finger protein, LIM domain interacting | -2.2903 |
| CTSD | cathepsin D | -2.28625 |
| AP2S1 | adaptor-related protein complex 2, sigma 1 subunit | -2.27168 |
| PFN1 | profilin 1 | -2.2601 |
| SLC17A6 | solute carrier family 17 (vesicular glutamate transporter), member 6 | -2.24695 |
| KRT5 | keratin 5, type II | -2.2205 |
| SENP7 | SUMO1/sentrin specific peptidase 7 | -2.1965 |
| ERCC1 | excision repair cross-complementation group 1 | -2.17733 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.16937 |
| SH3GLB2 | SH3-domain GRB2-like endophilin B2 | -2.16495 |
| AKR1D1 | aldo-keto reductase family 1, member D1 | -2.16325 |
| NLGN4Y | neuroligin 4, Y-linked | -2.16085 |
| ZNF692 | zinc finger protein 692 | -2.1593 |
| SLC6A1 | solute carrier family 6 (neurotransmitter transporter), member 1 | -2.1411 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -2.1333 |
| CLEC4A | C-type lectin domain family 4, member A | -2.12873 |
| PLXNB2 | plexin B2 | -2.10435 |
| GABARAP | GABA(A) receptor-associated protein | -2.09295 |
| SSR2 | signal sequence receptor, beta (translocon-associated protein beta) | -2.0827 |
| PGM1 | phosphoglucomutase 1 | -2.0818 |
| PABPC4 | poly(A) binding protein, cytoplasmic 4 (inducible form) | -2.0725 |
| ORM2 | orosomucoid 2 | -2.07085 |
| BRINP1 | bone morphogenetic protein/retinoic acid inducible neural-specific 1 | -2.06815 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -2.06105 |
| PABPC3 | poly(A) binding protein, cytoplasmic 3 | -2.06095 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.0546 |
| VASH1 | vasohibin 1 | -2.0518 |
| ALDH9A1 | aldehyde dehydrogenase 9 family, member A1 | -2.05105 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | -2.04405 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | -2.043 |
| MAN1B1 | mannosidase, alpha, class 1B, member 1 | -2.04297 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -2.0348 |
| RBM34 | RNA binding motif protein 34 | -2.03048 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.02362 |
| GID8 | GID complex subunit 8 | -2.0224 |
| TUBA1C | tubulin, alpha 1c | -2.02188 |
| MDM4 | MDM4, p53 regulator | -2.0123 |
