CRCGN008_HEPG2_24H:N24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description TCDD-dioxin 1.56 nm perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

100 genes differentially expressed following the CRCGN008_HEPG2_24H:N24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 6.3131
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 6.29665
VAT1 vesicle amine transport 1 6.157
STK10 serine/threonine kinase 10 5.2473
MYLK myosin light chain kinase 5.04305
LCN2 lipocalin 2 4.9003
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.84855
HOXA10 homeobox A10 4.81955
LOC122526780 uncharacterized LOC122526780 4.69975
RPP38 ribonuclease P/MRP 38kDa subunit 4.5847
GSTZ1 glutathione S-transferase zeta 1 4.43905
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.3724
RRAGA Ras-related GTP binding A 4.3653
CCL2 chemokine (C-C motif) ligand 2 4.23685
GARRE1 granule associated Rac and RHOG effector 1 3.9607
GPER1 G protein-coupled estrogen receptor 1 3.90177
PRR15L proline rich 15-like 3.88575
EGF epidermal growth factor 3.83675
SSBP2 single-stranded DNA binding protein 2 3.83225
TIAM1 T-cell lymphoma invasion and metastasis 1 3.83098
HMOX1 heme oxygenase 1 3.72575
SNAP25 synaptosomal-associated protein, 25kDa 3.59825
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.50695
RAP1GAP RAP1 GTPase activating protein 3.50415
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.4349
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.2016
CRYZ crystallin, zeta (quinone reductase) 3.0681
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.9762
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.9623
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.8955
MINDY1 MINDY lysine 48 deubiquitinase 1 2.88045
PLS1 plastin 1 2.8785
MVP major vault protein 2.8428
TXNRD1 thioredoxin reductase 1 2.80605
MAP7 microtubule-associated protein 7 2.59852
CYB561 cytochrome b561 2.55297
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.55257
CYCS cytochrome c, somatic 2.51645
BAG3 BCL2-associated athanogene 3 2.5029
TMEM50A transmembrane protein 50A 2.4611
NANOS3 nanos homolog 3 (Drosophila) 2.44835
CNPY3 canopy FGF signaling regulator 3 2.4315
MEST mesoderm specific transcript 2.3697
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.34657
RALB v-ral simian leukemia viral oncogene homolog B 2.3189
THAP4 THAP domain containing 4 2.3179
CAB39 calcium binding protein 39 2.27275
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.24975
GRB10 growth factor receptor-bound protein 10 2.24518
WDTC1 WD and tetratricopeptide repeats 1 2.23925
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.22678
SKIC8 SKI8 subunit of superkiller complex 2.16838
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 2.16615
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 2.1627
CDC25B cell division cycle 25B 2.1583
ETFA electron-transfer-flavoprotein, alpha polypeptide 2.158
BTBD3 BTB (POZ) domain containing 3 2.1327
SPX spexin hormone 2.12035
ESRP1 epithelial splicing regulatory protein 1 2.10245
LOC102723713 TP53-target gene 3 protein 2.0871
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.0549
STAP2 signal transducing adaptor family member 2 2.0537
OLFM4 olfactomedin 4 2.0224

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -5.5162
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -4.43005
ZMIZ1 zinc finger, MIZ-type containing 1 -4.3464
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -4.19977
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -3.7346
RNF167 ring finger protein 167 -3.6161
UGDH UDP-glucose 6-dehydrogenase -3.467
C5 complement component 5 -3.23385
DDIT4 DNA-damage-inducible transcript 4 -3.16105
MAPK13 mitogen-activated protein kinase 13 -2.9488
RBM15B RNA binding motif protein 15B -2.8567
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.79155
PSRC1 proline/serine-rich coiled-coil 1 -2.67525
IL4R interleukin 4 receptor -2.65655
AURKB aurora kinase B -2.6444
RBM34 RNA binding motif protein 34 -2.51373
SMIM29 small integral membrane protein 29 -2.4581
RHOBTB2 Rho-related BTB domain containing 2 -2.4016
SMYD5 SMYD family member 5 -2.333
GMCL1 germ cell-less, spermatogenesis associated 1 -2.3045
INSIG1 insulin induced gene 1 -2.20202
FHL2 four and a half LIM domains 2 -2.1854
ORM1 orosomucoid 1 -2.18292
STMN1 stathmin 1 -2.14895
RGS18 regulator of G-protein signaling 18 -2.12145
TRIB3 tribbles pseudokinase 3 -2.12005
RWDD2A RWD domain containing 2A -2.118
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.08955
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) -2.07795
ARID5B AT rich interactive domain 5B (MRF1-like) -2.0747
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.04995
LIAS lipoic acid synthetase -2.0381
F8 coagulation factor VIII, procoagulant component -2.03475
PADI3 peptidyl arginine deiminase, type III -2.0324
CRIPT cysteine-rich PDZ-binding protein -2.02955
HAT1 histone acetyltransferase 1 -2.01205
AIM2 absent in melanoma 2 -2.0032