CRCGN008_HEPG2_24H:O07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description beta-carotene 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

85 genes differentially expressed following the CRCGN008_HEPG2_24H:O07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NMU neuromedin U 5.71415
CCNF cyclin F 5.57578
CARMIL1 capping protein regulator and myosin 1 linker 1 5.2758
E2F2 E2F transcription factor 2 5.1218
TAC4 tachykinin 4 (hemokinin) 5.0
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.92165
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.58375
ADRB2 adrenoceptor beta 2, surface 4.5507
KCNK1 potassium channel, two pore domain subfamily K, member 1 4.39153
ABHD6 abhydrolase domain containing 6 4.37617
CCNH cyclin H 4.12785
HLA-DRA major histocompatibility complex, class II, DR alpha 4.1162
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.1124
SNAP25 synaptosomal-associated protein, 25kDa 3.76093
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.7316
CDPF1 cysteine-rich, DPF motif domain containing 1 3.65745
GPER1 G protein-coupled estrogen receptor 1 3.61615
CYCS cytochrome c, somatic 3.27665
PRR15L proline rich 15-like 3.2653
CHN1 chimerin 1 3.15815
SSBP2 single-stranded DNA binding protein 2 2.88632
CDC45 cell division cycle 45 2.86515
TMEM50A transmembrane protein 50A 2.82535
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.74962
TXNRD1 thioredoxin reductase 1 2.74955
LPAR2 lysophosphatidic acid receptor 2 2.71615
CHEK2 checkpoint kinase 2 2.71378
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.64813
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.6292
RRAGA Ras-related GTP binding A 2.5953
JADE2 jade family PHD finger 2 2.58773
CCP110 centriolar coiled coil protein 110kDa 2.56745
METRN meteorin, glial cell differentiation regulator 2.4369
GATA2 GATA binding protein 2 2.41293
TNP1 transition protein 1 (during histone to protamine replacement) 2.3552
PAQR3 progestin and adipoQ receptor family member III 2.2514
SLC17A2 solute carrier family 17, member 2 2.2495
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.24502
ARHGAP11A Rho GTPase activating protein 11A 2.239
HLF hepatic leukemia factor 2.19518
TBPL1 TBP-like 1 2.16385
SQSTM1 sequestosome 1 2.1103
TIPRL TOR signaling pathway regulator 2.07625
SFTPB surfactant protein B 2.05237
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.04675
NPY neuropeptide Y 2.0408
SYT13 synaptotagmin XIII 2.0369
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 2.0281
ICAM5 intercellular adhesion molecule 5, telencephalin 2.0064

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
LDHD lactate dehydrogenase D -10.0
NT5DC2 5'-nucleotidase domain containing 2 -6.06005
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.103
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.79255
CCNB1 cyclin B1 -4.65275
ZNF586 zinc finger protein 586 -4.6526
TLCD3A TLC domain containing 3A -4.6307
UGDH UDP-glucose 6-dehydrogenase -4.20395
PCCB propionyl CoA carboxylase, beta polypeptide -4.17815
MAPK13 mitogen-activated protein kinase 13 -3.74668
PGM1 phosphoglucomutase 1 -3.7069
ARHGAP1 Rho GTPase activating protein 1 -3.61335
RFC2 replication factor C (activator 1) 2, 40kDa -3.6076
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.52787
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -3.408
ZW10 zw10 kinetochore protein -3.16825
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.0414
S100A4 S100 calcium binding protein A4 -2.9019
CDC25B cell division cycle 25B -2.7861
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.77845
HSPA8 heat shock 70kDa protein 8 -2.63932
OXA1L oxidase (cytochrome c) assembly 1-like -2.55815
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.51595
EPS8L2 EPS8-like 2 -2.4786
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.31115
NRIP1 nuclear receptor interacting protein 1 -2.23058
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.1928
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -2.185
COG4 component of oligomeric golgi complex 4 -2.181
RTL8C retrotransposon Gag like 8C -2.1401
RAB15 RAB15, member RAS oncogene family -2.10127
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.08032
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.0598
PRPF31 pre-mRNA processing factor 31 -2.03063
ARAF A-Raf proto-oncogene, serine/threonine kinase -2.00515