CRCGN008_HEPG2_24H:O10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description beta-carotene 2.53 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

102 genes differentially expressed following the CRCGN008_HEPG2_24H:O10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 7.32255
STK10 serine/threonine kinase 10 6.83445
ATP11B ATPase, class VI, type 11B 5.9005
PLS1 plastin 1 5.6395
ADRB2 adrenoceptor beta 2, surface 5.3173
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.18696
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.9039
MYLK myosin light chain kinase 4.72205
NOSIP nitric oxide synthase interacting protein 4.46855
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.3431
MAMLD1 mastermind-like domain containing 1 4.31505
SSBP2 single-stranded DNA binding protein 2 3.99193
CHN1 chimerin 1 3.67595
ARL4C ADP-ribosylation factor-like 4C 3.6715
SFTPB surfactant protein B 3.58313
CCL2 chemokine (C-C motif) ligand 2 3.5641
CYCS cytochrome c, somatic 3.4533
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.40375
MAP7 microtubule-associated protein 7 3.39005
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.3074
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.19097
DYNLT3 dynein, light chain, Tctex-type 3 3.18735
GSTZ1 glutathione S-transferase zeta 1 3.1155
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.0496
TBC1D31 TBC1 domain family, member 31 3.03945
MTM1 myotubularin 1 2.85917
SMIM40 small integral membrane protein 40 2.52995
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 2.4936
USP6 ubiquitin specific peptidase 6 2.46735
TXNL4B thioredoxin-like 4B 2.4296
NEK7 NIMA-related kinase 7 2.4044
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.39418
LOC122526780 uncharacterized LOC122526780 2.357
TLR4 toll-like receptor 4 2.34255
KIF20A kinesin family member 20A 2.3412
USP6NL USP6 N-terminal like 2.2816
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.2437
BAX BCL2-associated X protein 2.24248
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.21145
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 2.18555
EPHA3 EPH receptor A3 2.16772
AP3B1 adaptor-related protein complex 3, beta 1 subunit 2.16153
XYLT1 xylosyltransferase I 2.15265
CYTH3 cytohesin 3 2.15085
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.14335
CDK19 cyclin-dependent kinase 19 2.13932
SNX10 sorting nexin 10 2.11075
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.0871
RBMXL2 RNA binding motif protein, X-linked-like 2 2.06235
WNT3 wingless-type MMTV integration site family, member 3 2.05905
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 2.0543
HARS1 histidyl-tRNA synthetase 1 2.05045
CREB1 cAMP responsive element binding protein 1 2.04276
FTCD formimidoyltransferase cyclodeaminase 2.0352
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 2.02245
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.01315
UBXN2B UBX domain protein 2B 2.01145

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
ZNF586 zinc finger protein 586 -6.50665
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -5.12963
ZMIZ1 zinc finger, MIZ-type containing 1 -5.00665
PCNA proliferating cell nuclear antigen -5.0
CCNB2 cyclin B2 -4.9883
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.38255
MTFR1 mitochondrial fission regulator 1 -3.84788
HMG20B high mobility group 20B -3.76858
SLC35F2 solute carrier family 35, member F2 -3.6538
OXA1L oxidase (cytochrome c) assembly 1-like -3.1112
ILK integrin-linked kinase -3.06045
PDE2A phosphodiesterase 2A, cGMP-stimulated -3.01415
ITGB1BP1 integrin beta 1 binding protein 1 -2.8871
CAB39 calcium binding protein 39 -2.77775
EXT1 exostosin glycosyltransferase 1 -2.61945
RNF167 ring finger protein 167 -2.5949
RHOG ras homolog family member G -2.507
TXNDC9 thioredoxin domain containing 9 -2.45835
LRP10 low density lipoprotein receptor-related protein 10 -2.4499
RNF24 ring finger protein 24 -2.44887
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -2.4028
NLRP4 NLR family, pyrin domain containing 4 -2.33855
MMD monocyte to macrophage differentiation-associated -2.3347
HSPA8 heat shock 70kDa protein 8 -2.32707
LRRC41 leucine rich repeat containing 41 -2.28485
SCAND1 SCAN domain containing 1 -2.2822
TRMT61B tRNA methyltransferase 61B -2.2636
LSM1 LSM1, U6 small nuclear RNA associated -2.2627
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B -2.19825
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -2.19295
UNC13D unc-13 homolog D (C. elegans) -2.1861
ARID3B AT rich interactive domain 3B (BRIGHT-like) -2.17635
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) -2.1317
TMEM243 transmembrane protein 243, mitochondrial -2.12905
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.0806
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) -2.06965
ADNP activity-dependent neuroprotector homeobox -2.0544
SELENOW selenoprotein W -2.0442
ZNF7 zinc finger protein 7 -2.03865
RBM15B RNA binding motif protein 15B -2.02215
SPATS2 spermatogenesis associated, serine-rich 2 -2.0184
ZNF587 zinc finger protein 587 -2.0059
HCK HCK proto-oncogene, Src family tyrosine kinase -2.00245
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.00195