CRCGN008_HEPG2_24H:O13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3'-methyl-4-dimethylaminoazobenzene 49.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

586 genes differentially expressed following the CRCGN008_HEPG2_24H:O13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
TXNRD1 thioredoxin reductase 1 8.4893
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 7.36
INPP1 inositol polyphosphate-1-phosphatase 7.2794
KLHL21 kelch-like family member 21 6.6063
ABHD4 abhydrolase domain containing 4 6.5635
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 6.55615
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 6.492
TUBB6 tubulin, beta 6 class V 6.34455
PRAF2 PRA1 domain family, member 2 6.2164
TRIB3 tribbles pseudokinase 3 6.16835
DDB2 damage-specific DNA binding protein 2, 48kDa 6.00985
CDC45 cell division cycle 45 5.979
FOSL1 FOS-like antigen 1 5.92065
VAT1 vesicle amine transport 1 5.67925
TERT telomerase reverse transcriptase 5.5998
KEAP1 kelch-like ECH-associated protein 1 5.487
C2CD2 C2 calcium-dependent domain containing 2 5.4424
ANKRD10 ankyrin repeat domain 10 5.1427
STX1A syntaxin 1A (brain) 5.0985
KHDC4 KH domain containing 4, pre-mRNA splicing factor 5.07015
DDIT4 DNA-damage-inducible transcript 4 4.95305
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 4.8561
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.83725
SKIC2 SKI2 subunit of superkiller complex 4.83105
NISCH nischarin 4.8166
E2F2 E2F transcription factor 2 4.8026
MICALL1 MICAL-like 1 4.70482
CCP110 centriolar coiled coil protein 110kDa 4.6732
LCN2 lipocalin 2 4.66275
CCL2 chemokine (C-C motif) ligand 2 4.62955
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 4.5914
RAP1GAP RAP1 GTPase activating protein 4.55645
BLCAP bladder cancer associated protein 4.51315
SQSTM1 sequestosome 1 4.40185
TERF2IP telomeric repeat binding factor 2, interacting protein 4.38095
PDCD11 programmed cell death 11 4.35795
PPARG peroxisome proliferator-activated receptor gamma 4.30885
TATDN2 TatD DNase domain containing 2 4.29175
TBP TATA box binding protein 4.19185
KDM5A lysine (K)-specific demethylase 5A 4.13437
CASC3 cancer susceptibility candidate 3 4.1123
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.03015
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 3.9688
TENT5A terminal nucleotidyltransferase 5A 3.93815
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.92865
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.7713
LOC122526780 uncharacterized LOC122526780 3.73295
GADD45A growth arrest and DNA-damage-inducible, alpha 3.7312
PLSCR3 phospholipid scramblase 3 3.64115
NPIPB5 nuclear pore complex interacting protein family, member B5 3.62965
ZFP36 ZFP36 ring finger protein 3.5709
SOCS2 suppressor of cytokine signaling 2 3.57048
TWNK twinkle mtDNA helicase 3.55285
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 3.53915
CCDC92 coiled-coil domain containing 92 3.5237
IER3 immediate early response 3 3.5047
UBE2A ubiquitin-conjugating enzyme E2A 3.4777
TOMM34 translocase of outer mitochondrial membrane 34 3.45175
RALGDS ral guanine nucleotide dissociation stimulator 3.4399
IP6K2 inositol hexakisphosphate kinase 2 3.41955
XPC xeroderma pigmentosum, complementation group C 3.40665
IL4R interleukin 4 receptor 3.3872
STIMATE STIM activating enhancer 3.36795
ZNF557 zinc finger protein 557 3.33585
MAP7 microtubule-associated protein 7 3.33272
DUSP14 dual specificity phosphatase 14 3.32735
CLBA1 clathrin binding box of aftiphilin containing 1 3.3205
PILRB paired immunoglobin-like type 2 receptor beta 3.31735
NSUN3 NOP2/Sun domain family, member 3 3.31695
GSTZ1 glutathione S-transferase zeta 1 3.2957
SLC75A1 solute carrier family 75 member 1 3.29
PNKP polynucleotide kinase 3'-phosphatase 3.2514
NOL8 nucleolar protein 8 3.2442
SESN1 sestrin 1 3.2181
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 3.2082
ATG9A autophagy related 9A 3.18665
ZBTB35 zinc finger and BTB domain containing 35 3.17885
DHDDS dehydrodolichyl diphosphate synthase 3.14555
ZNF629 zinc finger protein 629 3.1374
LSR lipolysis stimulated lipoprotein receptor 3.12725
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 3.0977
WDR4 WD repeat domain 4 3.08965
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 3.08885
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.08095
NAXD NAD(P)HX dehydratase 3.07465
IGHMBP2 immunoglobulin mu binding protein 2 3.06715
GDI1 GDP dissociation inhibitor 1 3.0119
NOLC1 nucleolar and coiled-body phosphoprotein 1 3.00907
TBXA2R thromboxane A2 receptor 3.00338
MCOLN1 mucolipin 1 2.9839
ELAC2 elaC ribonuclease Z 2 2.9827
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.97945
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.97705
USP19 ubiquitin specific peptidase 19 2.96625
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 2.93075
CGRRF1 cell growth regulator with ring finger domain 1 2.92145
TMEM43 transmembrane protein 43 2.915
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.8796
GSTM2 glutathione S-transferase mu 2 (muscle) 2.87805
ASPHD1 aspartate beta-hydroxylase domain containing 1 2.8774
KDM3A lysine (K)-specific demethylase 3A 2.863
CDC25B cell division cycle 25B 2.8627
FAM53C family with sequence similarity 53, member C 2.8553
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.85187
KIF17 kinesin family member 17 2.848
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.82575
CDC34 cell division cycle 34 2.8222
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.8147
ZDHHC11B zinc finger, DHHC-type containing 11B 2.80755
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.7975
NUP58 nucleoporin 58 2.79415
TKTL1 transketolase-like 1 2.78778
HPSE heparanase 2.77195
USP8 ubiquitin specific peptidase 8 2.77095
ULK1 unc-51 like autophagy activating kinase 1 2.7663
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.76295
GPC1 glypican 1 2.75487
SETD1A SET domain containing 1A 2.7492
PLK3 polo-like kinase 3 2.74305
TSPYL2 TSPY-like 2 2.73775
DNM1L dynamin 1-like 2.7354
PARP6 poly (ADP-ribose) polymerase family, member 6 2.7273
FASN fatty acid synthase 2.71354
ZFPM1 zinc finger protein, FOG family member 1 2.71095
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.70905
FBXW4 F-box and WD repeat domain containing 4 2.7042
CEP76 centrosomal protein 76kDa 2.69907
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.67442
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.6733
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 2.6685
MXD1 MAX dimerization protein 1 2.6622
FDXR ferredoxin reductase 2.6594
TWF2 twinfilin actin binding protein 2 2.65935
ISG20 interferon stimulated exonuclease gene 20kDa 2.65223
SRSF4 serine/arginine-rich splicing factor 4 2.64455
AEN apoptosis enhancing nuclease 2.6392
FAM193A family with sequence similarity 193, member A 2.62
GARS1 glycyl-tRNA synthetase 1 2.61775
ZNF410 zinc finger protein 410 2.61535
AGTPBP1 ATP/GTP binding protein 1 2.60765
CYCS cytochrome c, somatic 2.60205
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.6014
TOE1 target of EGR1, member 1 (nuclear) 2.5787
PRR14 proline rich 14 2.57683
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 2.5747
TARS1 threonyl-tRNA synthetase 1 2.57435
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 2.5695
IFI44 interferon-induced protein 44 2.56825
MYH13 myosin, heavy chain 13, skeletal muscle 2.56505
NUP85 nucleoporin 85kDa 2.56435
ZNF556 zinc finger protein 556 2.55305
ATG2A autophagy related 2A 2.5466
KLHL36 kelch-like family member 36 2.53645
ECM1 extracellular matrix protein 1 2.53415
LPAR2 lysophosphatidic acid receptor 2 2.52367
C6ORF89 chromosome 6 open reading frame 89 2.51888
TEX10 testis expressed 10 2.5127
ZNF79 zinc finger protein 79 2.51097
MAD2L1BP MAD2L1 binding protein 2.50205
BRD9 bromodomain containing 9 2.50155
RRAGA Ras-related GTP binding A 2.4832
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.48095
CNPY3 canopy FGF signaling regulator 3 2.4795
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.47762
BAG3 BCL2-associated athanogene 3 2.4709
TP53TG5 TP53 target 5 2.46935
ECD ecdysoneless homolog (Drosophila) 2.46785
PRKCD protein kinase C, delta 2.45925
IARS1 isoleucyl-tRNA synthetase 1 2.4584
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase 2.4528
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 2.44705
IFI6 interferon, alpha-inducible protein 6 2.4467
RNF103 ring finger protein 103 2.4459
ZNF768 zinc finger protein 768 2.43635
RHOB ras homolog family member B 2.4355
CSNK1E casein kinase 1, epsilon 2.43478
OTUD3 OTU deubiquitinase 3 2.43435
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.4327
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.4327
MARCHF5 membrane associated ring-CH-type finger 5 2.42775
WFS1 Wolfram syndrome 1 (wolframin) 2.4255
FBXL12 F-box and leucine-rich repeat protein 12 2.4229
SURF2 surfeit 2 2.42265
CDR2L cerebellar degeneration-related protein 2-like 2.41925
ZNF282 zinc finger protein 282 2.4133
KCTD17 potassium channel tetramerization domain containing 17 2.4074
UBE3C ubiquitin protein ligase E3C 2.401
TOB1 transducer of ERBB2, 1 2.38975
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 2.3895
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.38705
CDC37L1 cell division cycle 37-like 1 2.38685
YTHDC1 YTH domain containing 1 2.3868
HSFX2 heat shock transcription factor family, X linked 2 2.38445
CCDC51 coiled-coil domain containing 51 2.3713
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 2.36855
SCAF8 SR-related CTD-associated factor 8 2.36165
WDR6 WD repeat domain 6 2.35035
UNC13A unc-13 homolog A (C. elegans) 2.3462
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.34555
RNF25 ring finger protein 25 2.34385
GTPBP2 GTP binding protein 2 2.3428
IFI44L interferon-induced protein 44-like 2.3383
VAMP7 vesicle-associated membrane protein 7 2.3325
TBC1D3G TBC1 domain family member 3G 2.32385
NOP2 NOP2 nucleolar protein 2.31685
PLTP phospholipid transfer protein 2.30935
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 2.30205
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 2.2948
NCOA6 nuclear receptor coactivator 6 2.28505
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.28305
TIMP1 TIMP metallopeptidase inhibitor 1 2.28245
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.27495
ATF3 activating transcription factor 3 2.27225
TLE6 transducin-like enhancer of split 6 2.2719
PTH2R parathyroid hormone 2 receptor 2.2662
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.26325
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.24575
YARS1 tyrosyl-tRNA synthetase 1 2.2434
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.23765
TTF1 transcription termination factor, RNA polymerase I 2.23732
DGKD diacylglycerol kinase, delta 130kDa 2.236
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.2327
FASTKD5 FAST kinase domains 5 2.232
RSAD2 radical S-adenosyl methionine domain containing 2 2.22185
RAP1GAP2 RAP1 GTPase activating protein 2 2.2213
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.2213
TBC1D10B TBC1 domain family, member 10B 2.22115
GFI1 growth factor independent 1 transcription repressor 2.2188
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.21543
BTG3 BTG family, member 3 2.21323
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.21305
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 2.2114
MBD1 methyl-CpG binding domain protein 1 2.20875
ZNF593 zinc finger protein 593 2.20775
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.20715
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.2046
BUD31 BUD31 homolog (S. cerevisiae) 2.19985
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.1996
HDAC7 histone deacetylase 7 2.19395
STK11 serine/threonine kinase 11 2.1909
CRYBB3 crystallin, beta B3 2.18595
FXR2 fragile X mental retardation, autosomal homolog 2 2.18558
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 2.1831
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.1827
PRPF4 pre-mRNA processing factor 4 2.17788
DNAH17 dynein, axonemal, heavy chain 17 2.1769
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 2.17065
ZNF451 zinc finger protein 451 2.17015
EDC4 enhancer of mRNA decapping 4 2.1617
JMJD7 jumonji domain containing 7 2.1607
MVP major vault protein 2.1564
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.15525
KDM5C lysine (K)-specific demethylase 5C 2.1532
RNMT RNA (guanine-7-) methyltransferase 2.15147
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 2.15075
EAPP E2F-associated phosphoprotein 2.14575
SAMD9 sterile alpha motif domain containing 9 2.1446
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 2.1429
DUSP6 dual specificity phosphatase 6 2.14222
FOXK2 forkhead box K2 2.1412
PELO pelota homolog (Drosophila) 2.1381
TDRD12 tudor domain containing 12 2.13375
RPS27L ribosomal protein S27-like 2.12635
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.12455
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 2.12322
TRAPPC14 trafficking protein particle complex subunit 14 2.12185
BECN1 beclin 1, autophagy related 2.117
TRMO tRNA methyltransferase O 2.1124
GAPVD1 GTPase activating protein and VPS9 domains 1 2.1114
MEF2D myocyte enhancer factor 2D 2.1068
FHOD1 formin homology 2 domain containing 1 2.09955
LOC128125814 uncharacterized LOC128125814 2.0988
SETD5 SET domain containing 5 2.09845
ZYX zyxin 2.09675
CCSER2 coiled-coil serine-rich protein 2 2.09425
CH25H cholesterol 25-hydroxylase 2.08865
THSD1 thrombospondin, type I, domain containing 1 2.0871
TTC19 tetratricopeptide repeat domain 19 2.0835
BRD8 bromodomain containing 8 2.08235
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.07495
ISG15 ISG15 ubiquitin-like modifier 2.0742
E2F1 E2F transcription factor 1 2.0738
F8 coagulation factor VIII, procoagulant component 2.07265
PTPN3 protein tyrosine phosphatase, non-receptor type 3 2.0721
ATP13A1 ATPase type 13A1 2.07065
CSP2 CS pseudogene 2 2.07061
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 2.06995
USP36 ubiquitin specific peptidase 36 2.0667
PAGE1 P antigen family, member 1 (prostate associated) 2.0662
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 2.0654
EVPL envoplakin 2.06465
POLL polymerase (DNA directed), lambda 2.0646
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 2.0597
ABITRAM actin binding transcription modulator 2.0593
CSNK1G3 casein kinase 1, gamma 3 2.05905
RPAP1 RNA polymerase II associated protein 1 2.05885
NCBP3 nuclear cap binding subunit 3 2.05415
FAM3A family with sequence similarity 3, member A 2.05308
ALAS1 5'-aminolevulinate synthase 1 2.0527
FOXO3 forkhead box O3 2.0526
CAMTA2 calmodulin binding transcription activator 2 2.0517
CCDC86 coiled-coil domain containing 86 2.0516
GRK1 G protein-coupled receptor kinase 1 2.0459
TRIOBP TRIO and F-actin binding protein 2.04517
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 2.04505
PPP4R1 protein phosphatase 4, regulatory subunit 1 2.04
PDGFA platelet-derived growth factor alpha polypeptide 2.0394
CCDC57 coiled-coil domain containing 57 2.0367
RBM6 RNA binding motif protein 6 2.0363
CAMLG calcium modulating ligand 2.0347
ASB6 ankyrin repeat and SOCS box containing 6 2.03315
TIGAR TP53 induced glycolysis regulatory phosphatase 2.0308
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 2.02875
DXO decapping exoribonuclease 2.02532
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.02365
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 2.0205
RBM10 RNA binding motif protein 10 2.02018
RSRC2 arginine/serine-rich coiled-coil 2 2.02005
CLASRP CLK4-associating serine/arginine rich protein 2.0196
KCMF1 potassium channel modulatory factor 1 2.0163
SPAG1 sperm associated antigen 1 2.0136
YBX3 Y box binding protein 3 2.01275
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 2.00795
RGPD1 RANBP2-like and GRIP domain containing 1 2.0072
TENT2 terminal nucleotidyltransferase 2 2.00705
ATAD3A ATPase family, AAA domain containing 3A 2.0033
OXCT2 3-oxoacid CoA transferase 2 2.0027

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -9.1431
PSRC1 proline/serine-rich coiled-coil 1 -8.58775
PECR peroxisomal trans-2-enoyl-CoA reductase -8.1376
CDC20 cell division cycle 20 -7.53195
DERA deoxyribose-phosphate aldolase (putative) -6.68015
B4GAT1 beta-1,4-glucuronyltransferase 1 -6.51135
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -6.31465
ZNF586 zinc finger protein 586 -6.28565
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.19165
USP6NL USP6 N-terminal like -5.8249
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.82425
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -5.7374
CCNB2 cyclin B2 -5.7267
HAT1 histone acetyltransferase 1 -5.6871
OXA1L oxidase (cytochrome c) assembly 1-like -5.66115
MNAT1 MNAT CDK-activating kinase assembly factor 1 -5.5656
RSU1 Ras suppressor protein 1 -5.53155
LDHD lactate dehydrogenase D -5.4669
HMGA2 high mobility group AT-hook 2 -5.2365
TOP2A topoisomerase (DNA) II alpha 170kDa -5.2353
PCNA proliferating cell nuclear antigen -5.193
LAP3 leucine aminopeptidase 3 -5.15475
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.103
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -5.07835
ZW10 zw10 kinetochore protein -5.0145
PCCB propionyl CoA carboxylase, beta polypeptide -5.001
RFC2 replication factor C (activator 1) 2, 40kDa -4.82693
PLS1 plastin 1 -4.6086
PROS1 protein S (alpha) -4.5113
MSRA methionine sulfoxide reductase A -4.4988
ZMIZ1 zinc finger, MIZ-type containing 1 -4.47075
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.46042
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -4.36312
PLK1 polo-like kinase 1 -4.33095
PGM1 phosphoglucomutase 1 -4.2942
ALDOC aldolase C, fructose-bisphosphate -4.15635
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.0854
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -4.02678
ANO10 anoctamin 10 -3.991
TM9SF2 transmembrane 9 superfamily member 2 -3.92495
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -3.9089
ISOC1 isochorismatase domain containing 1 -3.87835
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -3.87658
DENND2D DENN/MADD domain containing 2D -3.773
SOAT2 sterol O-acyltransferase 2 -3.6578
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.63875
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -3.6141
PGAM4 phosphoglycerate mutase family member 4 -3.58885
ADAM10 ADAM metallopeptidase domain 10 -3.51697
NUP37 nucleoporin 37kDa -3.5049
RGS2 regulator of G-protein signaling 2 -3.48795
KLHDC2 kelch domain containing 2 -3.4741
PEG10 paternally expressed 10 -3.4443
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.40965
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -3.39145
AURKB aurora kinase B -3.38025
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -3.3686
LYRM4 LYR motif containing 4 -3.3269
ANAPC15 anaphase promoting complex subunit 15 -3.2981
PGK1 phosphoglycerate kinase 1 -3.29727
PHKB phosphorylase kinase, beta -3.27285
ACAA1 acetyl-CoA acyltransferase 1 -3.2353
MAP2K5 mitogen-activated protein kinase kinase 5 -3.22762
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -3.21333
TRAPPC6A trafficking protein particle complex 6A -3.131
KIF4A kinesin family member 4A -3.11505
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -3.0682
ECT2 epithelial cell transforming 2 -3.0464
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 -3.0464
A1CF APOBEC1 complementation factor -2.97035
NLRP2B NLR family pyrin domain containing 2B -2.96045
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.957
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.94685
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.93985
COMMD10 COMM domain containing 10 -2.9237
DET1 de-etiolated homolog 1 (Arabidopsis) -2.9237
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.89745
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.89377
LMNB1 lamin B1 -2.8435
HNMT histamine N-methyltransferase -2.78382
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.77985
PDZD2 PDZ domain containing 2 -2.76813
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.75385
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.7509
CPQ carboxypeptidase Q -2.74517
ERI3 ERI1 exoribonuclease family member 3 -2.73445
PID1 phosphotyrosine interaction domain containing 1 -2.72825
DPYD dihydropyrimidine dehydrogenase -2.7259
PTPRK protein tyrosine phosphatase, receptor type, K -2.7127
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.70533
SLIT2 slit homolog 2 (Drosophila) -2.69585
LOC124907782 dual specificity protein phosphatase 22 -2.68465
RHOBTB1 Rho-related BTB domain containing 1 -2.68075
PRUNE1 prune exopolyphosphatase 1 -2.66892
CRELD2 cysteine-rich with EGF-like domains 2 -2.6597
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -2.65875
CPPED1 calcineurin-like phosphoesterase domain containing 1 -2.64525
PLG plasminogen -2.64515
ECH1 enoyl CoA hydratase 1, peroxisomal -2.63415
CCNA2 cyclin A2 -2.62733
MRPL48 mitochondrial ribosomal protein L48 -2.62195
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.6189
ELP4 elongator acetyltransferase complex subunit 4 -2.61445
WDR7 WD repeat domain 7 -2.61
SELENOF selenoprotein F -2.58985
VAV3 vav 3 guanine nucleotide exchange factor -2.583
CDK1 cyclin-dependent kinase 1 -2.58297
ADI1 acireductone dioxygenase 1 -2.5666
MYLK myosin light chain kinase -2.5587
NUCB2 nucleobindin 2 -2.54285
EIF2D eukaryotic translation initiation factor 2D -2.5358
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.53495
GLOD4 glyoxalase domain containing 4 -2.5285
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) -2.5255
GPC5 glypican 5 -2.5209
ERBIN erbb2 interacting protein -2.5187
KCTD12 potassium channel tetramerization domain containing 12 -2.51458
CNN3 calponin 3, acidic -2.5058
HYOU1 hypoxia up-regulated 1 -2.50555
C2CD5 C2 calcium-dependent domain containing 5 -2.49965
ILK integrin-linked kinase -2.4916
NCK1 NCK adaptor protein 1 -2.47975
HSPA8 heat shock 70kDa protein 8 -2.47718
GASK1B golgi associated kinase 1B -2.47105
RNASE4 ribonuclease, RNase A family, 4 -2.45607
SLC30A10 solute carrier family 30, member 10 -2.45335
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.44115
CPVL carboxypeptidase, vitellogenic-like -2.4226
GTF2A2 general transcription factor IIA, 2, 12kDa -2.42105
TCTN1 tectonic family member 1 -2.4187
HSPE1 heat shock 10kDa protein 1 -2.4157
ATP5F1C ATP synthase F1 subunit gamma -2.4156
PBK PDZ binding kinase -2.41505
EFHD2 EF-hand domain family, member D2 -2.41325
FCN1 ficolin (collagen/fibrinogen domain containing) 1 -2.4029
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -2.401
ABT1 activator of basal transcription 1 -2.3934
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 -2.39045
TMED7 transmembrane emp24 protein transport domain containing 7 -2.38925
APOE apolipoprotein E -2.38815
APOM apolipoprotein M -2.37953
PRMT1 protein arginine methyltransferase 1 -2.37795
MRTFB myocardin related transcription factor B -2.3745
CFHR2 complement factor H-related 2 -2.37245
FGA fibrinogen alpha chain -2.36303
FGL2 fibrinogen-like 2 -2.3591
ANXA7 annexin A7 -2.3498
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.3427
SPA17 sperm autoantigenic protein 17 -2.3287
CA14 carbonic anhydrase XIV -2.3281
MYL9 myosin, light chain 9, regulatory -2.31985
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -2.3172
SPTBN2 spectrin, beta, non-erythrocytic 2 -2.3148
SAMM50 SAMM50 sorting and assembly machinery component -2.3017
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.29775
ANG angiogenin, ribonuclease, RNase A family, 5 -2.2905
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.28095
IQGAP2 IQ motif containing GTPase activating protein 2 -2.2786
MRPS27 mitochondrial ribosomal protein S27 -2.2753
KCTD20 potassium channel tetramerization domain containing 20 -2.27445
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -2.27345
MTFR1 mitochondrial fission regulator 1 -2.2703
ACTL6A actin-like 6A -2.26845
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.2655
AP3B1 adaptor-related protein complex 3, beta 1 subunit -2.26485
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) -2.25625
ESM1 endothelial cell-specific molecule 1 -2.24965
FPGT fucose-1-phosphate guanylyltransferase -2.2482
PPP1R7 protein phosphatase 1, regulatory subunit 7 -2.24235
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.24222
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.2366
HADH hydroxyacyl-CoA dehydrogenase -2.23448
UGP2 UDP-glucose pyrophosphorylase 2 -2.22855
ECSIT ECSIT signalling integrator -2.2168
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.21603
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -2.2088
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 -2.20837
TRAPPC3 trafficking protein particle complex 3 -2.20805
SCGB1D1 secretoglobin, family 1D, member 1 -2.20688
PARP1 poly (ADP-ribose) polymerase 1 -2.2056
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -2.20555
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.20495
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.2043
CDCA3 cell division cycle associated 3 -2.2039
CFI complement factor I -2.198
ADCY7 adenylate cyclase 7 -2.1948
ZNF91 zinc finger protein 91 -2.1934
DCPS decapping enzyme, scavenger -2.18685
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.18655
C5 complement component 5 -2.182
MAPK13 mitogen-activated protein kinase 13 -2.1755
HMGB2 high mobility group box 2 -2.16325
KIF15 kinesin family member 15 -2.15965
TFRC transferrin receptor -2.15838
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.1583
TMEM35A transmembrane protein 35A -2.1501
ACO1 aconitase 1, soluble -2.1486
ASIC2 acid sensing (proton gated) ion channel 2 -2.14455
CHI3L2 chitinase 3-like 2 -2.14395
CHEK2 checkpoint kinase 2 -2.13283
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -2.1321
PCYOX1 prenylcysteine oxidase 1 -2.12075
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.1203
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -2.1187
RB1 retinoblastoma 1 -2.11693
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -2.11465
NUP93 nucleoporin 93kDa -2.1109
CRIPTO3 cripto, EGF-CFC family member 3 -2.1096
LGALS8 lectin, galactoside-binding, soluble, 8 -2.09903
GDI2 GDP dissociation inhibitor 2 -2.09768
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 -2.0905
LBR lamin B receptor -2.08985
NCAPD2 non-SMC condensin I complex, subunit D2 -2.08965
SLC35F2 solute carrier family 35, member F2 -2.08965
CDK14 cyclin-dependent kinase 14 -2.08208
CCDC170 coiled-coil domain containing 170 -2.07645
MEX3D mex-3 RNA binding family member D -2.07385
ACOX2 acyl-CoA oxidase 2, branched chain -2.0703
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -2.06927
PDGFD platelet derived growth factor D -2.0691
FGB fibrinogen beta chain -2.067
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 -2.0667
COL1A2 collagen, type I, alpha 2 -2.06118
MAP2K6 mitogen-activated protein kinase kinase 6 -2.05993
KNG1 kininogen 1 -2.05932
ATL2 atlastin GTPase 2 -2.0593
FZD2 frizzled class receptor 2 -2.0593
TMPO thymopoietin -2.05882
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -2.05495
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) -2.05445
RAB15 RAB15, member RAS oncogene family -2.05397
ISOC2 isochorismatase domain containing 2 -2.0467
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.04655
PKLR pyruvate kinase, liver and RBC -2.04388
LMAN1 lectin, mannose-binding, 1 -2.04168
MEFV Mediterranean fever -2.04
ASGR2 asialoglycoprotein receptor 2 -2.03925
MAGT1 magnesium transporter 1 -2.03875
ZIC1 Zic family member 1 -2.03805
FGFR4 fibroblast growth factor receptor 4 -2.03735
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 -2.0369
ASGR1 asialoglycoprotein receptor 1 -2.03495
DEK DEK proto-oncogene -2.03465
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -2.03436
PRCP prolylcarboxypeptidase (angiotensinase C) -2.02395
CENPA centromere protein A -2.02355
PDE4B phosphodiesterase 4B, cAMP-specific -2.0229
CTSB cathepsin B -2.0227
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.02045
IRF6 interferon regulatory factor 6 -2.0184
GLCE glucuronic acid epimerase -2.0143
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -2.0106
TEP1 telomerase-associated protein 1 -2.0093
EPHX2 epoxide hydrolase 2, cytoplasmic -2.00885
TNS3 tensin 3 -2.0081
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.00775
RPIA ribose 5-phosphate isomerase A -2.0012