CRCGN008_HEPG2_24H:O17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3'-methyl-4-dimethylaminoazobenzene 3.08 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

324 genes differentially expressed following the CRCGN008_HEPG2_24H:O17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
DDIT4 DNA-damage-inducible transcript 4 7.69865
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 7.05503
E2F2 E2F transcription factor 2 6.6284
TRIB3 tribbles pseudokinase 3 6.4778
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.85405
ADRB2 adrenoceptor beta 2, surface 5.84075
DDB2 damage-specific DNA binding protein 2, 48kDa 5.8298
CBR3 carbonyl reductase 3 5.5895
INPP1 inositol polyphosphate-1-phosphatase 5.2317
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 5.16745
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.1052
EPHB2 EPH receptor B2 4.89451
BLCAP bladder cancer associated protein 4.8528
CCL2 chemokine (C-C motif) ligand 2 4.83795
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.8105
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.76375
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.7385
LCN2 lipocalin 2 4.7003
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 4.67215
BACE2 beta-site APP-cleaving enzyme 2 4.58615
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 4.5183
TERT telomerase reverse transcriptase 4.2944
CXCR4 chemokine (C-X-C motif) receptor 4 4.28307
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 4.23035
CCDC85B coiled-coil domain containing 85B 4.173
STAP2 signal transducing adaptor family member 2 4.1593
TCERG1 transcription elongation regulator 1 4.0969
UBE2A ubiquitin-conjugating enzyme E2A 4.0714
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.02392
SNAP25 synaptosomal-associated protein, 25kDa 4.0132
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.95525
SESN1 sestrin 1 3.7904
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.72363
NISCH nischarin 3.70535
TXLNA taxilin alpha 3.70355
STX1A syntaxin 1A (brain) 3.6514
CH25H cholesterol 25-hydroxylase 3.6369
MAP7 microtubule-associated protein 7 3.56732
MICALL1 MICAL-like 1 3.5498
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.5188
KIFBP kinesin family binding protein 3.454
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.4435
FOSL1 FOS-like antigen 1 3.38975
ZFP36 ZFP36 ring finger protein 3.38325
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 3.3542
KLHL21 kelch-like family member 21 3.3453
KHDC4 KH domain containing 4, pre-mRNA splicing factor 3.3413
ABHD4 abhydrolase domain containing 4 3.33315
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.31577
CYCS cytochrome c, somatic 3.2903
KEAP1 kelch-like ECH-associated protein 1 3.28835
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 3.2049
TUBB6 tubulin, beta 6 class V 3.1721
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 3.1339
IER3 immediate early response 3 3.11965
PRAF2 PRA1 domain family, member 2 3.11825
SPAG1 sperm associated antigen 1 3.094
FNBP4 formin binding protein 4 3.07305
TBP TATA box binding protein 3.0552
PROSER1 proline and serine rich 1 2.9896
TBXA2R thromboxane A2 receptor 2.89775
KDM7A lysine (K)-specific demethylase 7A 2.87185
OASL 2'-5'-oligoadenylate synthetase-like 2.80418
ALAS1 5'-aminolevulinate synthase 1 2.7804
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.7781
BPHL biphenyl hydrolase-like (serine hydrolase) 2.77505
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.77268
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.7569
CDX1 caudal type homeobox 1 2.7374
TTC19 tetratricopeptide repeat domain 19 2.71575
NCBP3 nuclear cap binding subunit 3 2.7043
TXNRD1 thioredoxin reductase 1 2.6849
LGALS4 lectin, galactoside-binding, soluble, 4 2.6772
KDM3A lysine (K)-specific demethylase 3A 2.65535
GADD45A growth arrest and DNA-damage-inducible, alpha 2.6477
KDM5A lysine (K)-specific demethylase 5A 2.64162
VAT1 vesicle amine transport 1 2.6407
CDC25B cell division cycle 25B 2.60755
ZBTB35 zinc finger and BTB domain containing 35 2.59368
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.59095
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.5791
ULK1 unc-51 like autophagy activating kinase 1 2.5697
ELAC2 elaC ribonuclease Z 2 2.56715
CHN1 chimerin 1 2.56685
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.56587
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 2.56285
RCOR1 REST corepressor 1 2.51825
ULBP2 UL16 binding protein 2 2.5182
DYSF dysferlin 2.50975
CCL24 chemokine (C-C motif) ligand 24 2.504
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.484
TP53BP2 tumor protein p53 binding protein 2 2.47915
MYOM2 myomesin 2 2.4749
AEN apoptosis enhancing nuclease 2.46515
SHB Src homology 2 domain containing adaptor protein B 2.4608
IL4R interleukin 4 receptor 2.4454
COL16A1 collagen, type XVI, alpha 1 2.4384
FOXO3 forkhead box O3 2.43022
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 2.41953
CKM creatine kinase, muscle 2.40375
LPAR2 lysophosphatidic acid receptor 2 2.40158
DUSP14 dual specificity phosphatase 14 2.39735
RRAGA Ras-related GTP binding A 2.38615
CASC3 cancer susceptibility candidate 3 2.37825
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.36895
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 2.3658
YTHDC1 YTH domain containing 1 2.3461
DNMBP dynamin binding protein 2.3397
TWF2 twinfilin actin binding protein 2 2.33945
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 2.32305
WIPF2 WAS/WASL interacting protein family, member 2 2.3205
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.29845
EGR1 early growth response 1 2.29265
CLCA2 chloride channel accessory 2 2.28325
SRPK3 SRSF protein kinase 3 2.2799
TEX10 testis expressed 10 2.27945
TRAPPC10 trafficking protein particle complex 10 2.27752
ECD ecdysoneless homolog (Drosophila) 2.2768
CHEK2 checkpoint kinase 2 2.26795
NRBF2 nuclear receptor binding factor 2 2.26325
CCNJ cyclin J 2.25835
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.25515
SQSTM1 sequestosome 1 2.25338
PRR15L proline rich 15-like 2.23435
DOCK6 dedicator of cytokinesis 6 2.21865
ZBTB39 zinc finger and BTB domain containing 39 2.21855
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2.21795
ERCC3 excision repair cross-complementation group 3 2.2167
FES FES proto-oncogene, tyrosine kinase 2.20955
CD8A CD8a molecule 2.2089
ZNF451 zinc finger protein 451 2.20887
LUC7L2 LUC7-like 2 (S. cerevisiae) 2.20105
LRP10 low density lipoprotein receptor-related protein 10 2.19865
PDCD11 programmed cell death 11 2.19062
PHAF1 phagosome assembly factor 1 2.1793
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 2.17765
NOX1 NADPH oxidase 1 2.17443
GUCY2C guanylate cyclase 2C 2.15405
PYGM phosphorylase, glycogen, muscle 2.121
CCNF cyclin F 2.11385
TIGAR TP53 induced glycolysis regulatory phosphatase 2.11335
FERMT1 fermitin family member 1 2.1075
HPSE heparanase 2.10075
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.09847
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.09055
HBEGF heparin-binding EGF-like growth factor 2.08835
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.08078
ISLR immunoglobulin superfamily containing leucine-rich repeat 2.0702
CUTC cutC copper transporter 2.069
MAD2L1BP MAD2L1 binding protein 2.0634
MXD1 MAX dimerization protein 1 2.04985
KLHL41 kelch-like family member 41 2.0496
ENOPH1 enolase-phosphatase 1 2.0471
NKG7 natural killer cell granule protein 7 2.0446
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.0388
KLHDC4 kelch domain containing 4 2.0383
GPR153 G protein-coupled receptor 153 2.02667
ATF3 activating transcription factor 3 2.02615
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 2.02575
MEST mesoderm specific transcript 2.0194
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.01898
NOLC1 nucleolar and coiled-body phosphoprotein 1 2.01575

decreased expression

Symbol Name Standardized Value
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -6.7454
MSRA methionine sulfoxide reductase A -6.46725
USP6NL USP6 N-terminal like -6.0827
ADI1 acireductone dioxygenase 1 -5.6374
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.6295
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.47265
PEG10 paternally expressed 10 -5.28125
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.17025
PSRC1 proline/serine-rich coiled-coil 1 -5.17005
ZNF586 zinc finger protein 586 -5.14975
DSG2 desmoglein 2 -5.0752
RSU1 Ras suppressor protein 1 -5.0604
ZW10 zw10 kinetochore protein -4.90765
PECR peroxisomal trans-2-enoyl-CoA reductase -4.83305
PCNA proliferating cell nuclear antigen -4.77245
MNAT1 MNAT CDK-activating kinase assembly factor 1 -4.72515
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.64675
ANO10 anoctamin 10 -4.64465
RAI14 retinoic acid induced 14 -4.60695
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.3575
DNM1L dynamin 1-like -4.0004
CBR1 carbonyl reductase 1 -3.92835
PGM1 phosphoglucomutase 1 -3.7255
GNAS GNAS complex locus -3.71685
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.70732
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -3.56525
ACAA1 acetyl-CoA acyltransferase 1 -3.54448
SPAG4 sperm associated antigen 4 -3.45735
ZMIZ1 zinc finger, MIZ-type containing 1 -3.44805
S100A4 S100 calcium binding protein A4 -3.37145
WDR7 WD repeat domain 7 -3.3133
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -3.29892
NUCB2 nucleobindin 2 -3.2384
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.1324
ALDOC aldolase C, fructose-bisphosphate -3.12895
PLS1 plastin 1 -3.11685
PDZD2 PDZ domain containing 2 -3.10155
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.94025
SLC35F2 solute carrier family 35, member F2 -2.9154
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.89542
CLTB clathrin, light chain B -2.88934
OXA1L oxidase (cytochrome c) assembly 1-like -2.87605
HYOU1 hypoxia up-regulated 1 -2.84085
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.83755
ANKRD10 ankyrin repeat domain 10 -2.8333
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.80978
CCNB1 cyclin B1 -2.7791
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.73283
TCEAL4 transcription elongation factor A (SII)-like 4 -2.71675
PLS3 plastin 3 -2.7024
SLC39A1 solute carrier family 39 (zinc transporter), member 1 -2.69365
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.68705
ZNF91 zinc finger protein 91 -2.66195
UGP2 UDP-glucose pyrophosphorylase 2 -2.65965
FLOT2 flotillin 2 -2.64485
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 -2.64305
SMIM10L1 small integral membrane protein 10 like 1 -2.64095
FOS FBJ murine osteosarcoma viral oncogene homolog -2.6151
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -2.5903
RHOBTB1 Rho-related BTB domain containing 1 -2.5815
THAP11 THAP domain containing 11 -2.5779
PCOLCE2 procollagen C-endopeptidase enhancer 2 -2.557
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 -2.53905
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -2.51373
DPYD dihydropyrimidine dehydrogenase -2.512
SNX11 sorting nexin 11 -2.50685
MPPED2 metallophosphoesterase domain containing 2 -2.49292
CETN3 centrin, EF-hand protein, 3 -2.49045
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.49018
LOC124907782 dual specificity protein phosphatase 22 -2.4858
ENTREP2 endosomal transmembrane epsin interactor 2 -2.4784
PGAM4 phosphoglycerate mutase family member 4 -2.45445
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.4495
LEP leptin -2.4431
SCARB1 scavenger receptor class B, member 1 -2.41735
MINPP1 multiple inositol-polyphosphate phosphatase 1 -2.41575
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.36997
GCHFR GTP cyclohydrolase I feedback regulator -2.3633
TRAPPC6A trafficking protein particle complex 6A -2.36045
ATF5 activating transcription factor 5 -2.35072
RAB4B RAB4B, member RAS oncogene family -2.3505
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -2.34738
OCEL1 occludin/ELL domain containing 1 -2.343
AQP5 aquaporin 5 -2.33685
PFKP phosphofructokinase, platelet -2.32555
CRELD2 cysteine-rich with EGF-like domains 2 -2.3237
KLHDC2 kelch domain containing 2 -2.3195
MAGT1 magnesium transporter 1 -2.31515
GTF2A2 general transcription factor IIA, 2, 12kDa -2.3117
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.3038
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -2.2969
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.2949
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.29055
FICD FIC domain containing -2.28895
TMED9 transmembrane emp24 protein transport domain containing 9 -2.28667
GAP43 growth associated protein 43 -2.27458
PDIA3 protein disulfide isomerase family A, member 3 -2.27365
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.2443
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.2282
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -2.22415
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.22235
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -2.22125
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit -2.2191
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -2.2116
MLF2 myeloid leukemia factor 2 -2.2069
TMEM230 transmembrane protein 230 -2.2066
MRPS35 mitochondrial ribosomal protein S35 -2.20493
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 -2.20155
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.1947
ACLY ATP citrate lyase -2.19337
MRPS27 mitochondrial ribosomal protein S27 -2.1879
PCCB propionyl CoA carboxylase, beta polypeptide -2.1877
ERBIN erbb2 interacting protein -2.18625
ZNF281 zinc finger protein 281 -2.1806
MTFR1 mitochondrial fission regulator 1 -2.18027
TAGLN2 transgelin 2 -2.17823
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.17322
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 -2.17208
MDH1 malate dehydrogenase 1, NAD (soluble) -2.17025
CNN3 calponin 3, acidic -2.16575
RIPOR2 RHO family interacting cell polarization regulator 2 -2.16115
TMED7 transmembrane emp24 protein transport domain containing 7 -2.16033
KL klotho -2.1581
LIN37 lin-37 DREAM MuvB core complex component -2.15565
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.15395
NR1H4 nuclear receptor subfamily 1, group H, member 4 -2.1425
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.13505
C2CD5 C2 calcium-dependent domain containing 5 -2.13375
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -2.13145
SCGB1D1 secretoglobin, family 1D, member 1 -2.12865
BFAR bifunctional apoptosis regulator -2.12095
PRMT1 protein arginine methyltransferase 1 -2.1158
TUBA1B tubulin, alpha 1b -2.11495
ZNF304 zinc finger protein 304 -2.1101
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -2.10667
TCTN1 tectonic family member 1 -2.1063
GLDC glycine dehydrogenase (decarboxylating) -2.104
CALB2 calbindin 2 -2.101
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.10085
ERGIC2 ERGIC and golgi 2 -2.08895
VNN2 vanin 2 -2.0844
ZNF667 zinc finger protein 667 -2.08075
AKAP8 A kinase (PRKA) anchor protein 8 -2.07433
KIF14 kinesin family member 14 -2.0715
MDFIC MyoD family inhibitor domain containing -2.07132
TSPAN6 tetraspanin 6 -2.0694
MTA1 metastasis associated 1 -2.0689
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.0685
XYLT1 xylosyltransferase I -2.0616
NTAQ1 N-terminal glutamine amidase 1 -2.06055
EXT1 exostosin glycosyltransferase 1 -2.0477
ZNF415 zinc finger protein 415 -2.02875
TRIM52 tripartite motif containing 52 -2.0276
STAT1 signal transducer and activator of transcription 1, 91kDa -2.02472
ZFP30 ZFP30 zinc finger protein -2.0194
SELENOT selenoprotein T -2.0178
AMDHD2 amidohydrolase domain containing 2 -2.01685
LGALS14 lectin, galactoside-binding, soluble, 14 -2.0167
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -2.0115
SLC35B1 solute carrier family 35, member B1 -2.00855
TXNL1 thioredoxin-like 1 -2.00285