CRCGN008_HEPG2_24H:O18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3'-methyl-4-dimethylaminoazobenzene 1.54 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

331 genes differentially expressed following the CRCGN008_HEPG2_24H:O18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 10.0
DDIT4 DNA-damage-inducible transcript 4 7.5133
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 6.87395
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 6.61735
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 6.4602
DDB2 damage-specific DNA binding protein 2, 48kDa 5.4893
ABHD4 abhydrolase domain containing 4 5.2399
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.15365
E2F2 E2F transcription factor 2 5.01895
ATP11B ATPase, class VI, type 11B 4.65895
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.5815
BACE2 beta-site APP-cleaving enzyme 2 4.5193
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.49468
TBC1D31 TBC1 domain family, member 31 4.26265
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 4.1453
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.05955
BLCAP bladder cancer associated protein 4.05455
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 4.00885
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 3.9952
INPP1 inositol polyphosphate-1-phosphatase 3.88885
CBR3 carbonyl reductase 3 3.88495
KHDC4 KH domain containing 4, pre-mRNA splicing factor 3.85245
TBPL1 TBP-like 1 3.83105
MICALL1 MICAL-like 1 3.80928
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.71705
FDXR ferredoxin reductase 3.6246
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.618
FOSL1 FOS-like antigen 1 3.5966
ZBTB35 zinc finger and BTB domain containing 35 3.58212
BAX BCL2-associated X protein 3.57345
TUBB6 tubulin, beta 6 class V 3.5662
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 3.56075
PRAF2 PRA1 domain family, member 2 3.50755
RGS2 regulator of G-protein signaling 2 3.4813
AEN apoptosis enhancing nuclease 3.47205
LPAR2 lysophosphatidic acid receptor 2 3.47135
IER3 immediate early response 3 3.36205
TBP TATA box binding protein 3.35155
ANKRD10 ankyrin repeat domain 10 3.22335
CCP110 centriolar coiled coil protein 110kDa 3.20805
TERT telomerase reverse transcriptase 3.15625
FPGS folylpolyglutamate synthase 3.1526
KLHL21 kelch-like family member 21 3.149
NUP85 nucleoporin 85kDa 3.07395
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 3.0235
TXNRD1 thioredoxin reductase 1 3.012
SACS sacsin molecular chaperone 2.98495
PRR15L proline rich 15-like 2.9534
TERF2IP telomeric repeat binding factor 2, interacting protein 2.94555
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.90185
DUSP3 dual specificity phosphatase 3 2.87443
RFWD3 ring finger and WD repeat domain 3 2.85035
KIFBP kinesin family binding protein 2.8102
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.80465
PEX13 peroxisomal biogenesis factor 13 2.7984
TIGAR TP53 induced glycolysis regulatory phosphatase 2.7703
STX1A syntaxin 1A (brain) 2.7328
ERCC3 excision repair cross-complementation group 3 2.72325
GADD45A growth arrest and DNA-damage-inducible, alpha 2.68995
PSIP1 PC4 and SFRS1 interacting protein 1 2.65767
EVL Enah/Vasp-like 2.6347
ELAC2 elaC ribonuclease Z 2 2.6305
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.61735
ARID4B AT rich interactive domain 4B (RBP1-like) 2.56505
WDR47 WD repeat domain 47 2.56055
CCDC93 coiled-coil domain containing 93 2.48455
FNBP4 formin binding protein 4 2.47485
NRBF2 nuclear receptor binding factor 2 2.46125
TEX10 testis expressed 10 2.4585
HEBP1 heme binding protein 1 2.4373
DUSP6 dual specificity phosphatase 6 2.42442
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 2.4205
KDM3A lysine (K)-specific demethylase 3A 2.42035
MDN1 MDN1, midasin homolog (yeast) 2.40485
EGR1 early growth response 1 2.38198
RNMT RNA (guanine-7-) methyltransferase 2.37832
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.36723
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 2.3623
PYGB phosphorylase, glycogen; brain 2.3561
ZNF79 zinc finger protein 79 2.32708
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.32465
NKG7 natural killer cell granule protein 7 2.31985
TSC22D3 TSC22 domain family, member 3 2.31732
PCNA proliferating cell nuclear antigen 2.3161
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 2.31037
MTPAP mitochondrial poly(A) polymerase 2.3034
SBNO1 strawberry notch homolog 1 (Drosophila) 2.30035
TOMM34 translocase of outer mitochondrial membrane 34 2.29535
PDCD11 programmed cell death 11 2.28375
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2.2786
RALGDS ral guanine nucleotide dissociation stimulator 2.2695
VCPKMT valosin containing protein lysine (K) methyltransferase 2.26625
HAUS6 HAUS augmin-like complex, subunit 6 2.26455
RESF1 retroelement silencing factor 1 2.26005
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 2.2539
TWNK twinkle mtDNA helicase 2.25135
WIPF2 WAS/WASL interacting protein family, member 2 2.23667
PIWIL2 piwi-like RNA-mediated gene silencing 2 2.2332
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 2.2258
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.22318
PSPC1 paraspeckle component 1 2.2178
PLK3 polo-like kinase 3 2.212
FAM168B family with sequence similarity 168, member B 2.2114
NISCH nischarin 2.20965
KDM5A lysine (K)-specific demethylase 5A 2.20062
GABARAPL1 GABA(A) receptor-associated protein like 1 2.19798
CCNJ cyclin J 2.19725
ERCC2 excision repair cross-complementation group 2 2.1814
FANCG Fanconi anemia, complementation group G 2.1765
RPAP3 RNA polymerase II associated protein 3 2.1638
PILRB paired immunoglobin-like type 2 receptor beta 2.15745
SAC3D1 SAC3 domain containing 1 2.14095
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.1312
ATG14 autophagy related 14 2.1151
FASN fatty acid synthase 2.11347
NIP7 NIP7, nucleolar pre-rRNA processing protein 2.1109
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.10775
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 2.10332
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.10155
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.09475
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 2.0915
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) 2.0886
CLBA1 clathrin binding box of aftiphilin containing 1 2.07845
RNF146 ring finger protein 146 2.07785
VAT1 vesicle amine transport 1 2.077
RHOA ras homolog family member A 2.07675
SMG8 SMG8 nonsense mediated mRNA decay factor 2.07365
TLR4 toll-like receptor 4 2.07205
ZNF451 zinc finger protein 451 2.0689
SLC25A38 solute carrier family 25, member 38 2.0686
BMAL2 basic helix-loop-helix ARNT like 2 2.0685
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 2.06845
PRPF39 pre-mRNA processing factor 39 2.06785
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa 2.06525
RPAP2 RNA polymerase II associated protein 2 2.06335
CCDC22 coiled-coil domain containing 22 2.05562
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 2.05315
CDT1 chromatin licensing and DNA replication factor 1 2.0528
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 2.05232
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.0514
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 2.0481
KIF17 kinesin family member 17 2.0472
ZMAT3 zinc finger, matrin-type 3 2.04555
SQSTM1 sequestosome 1 2.0435
SPAG1 sperm associated antigen 1 2.04185
RBM48 RNA binding motif protein 48 2.03778
SCYL3 SCY1-like 3 (S. cerevisiae) 2.03745
PSAT1 phosphoserine aminotransferase 1 2.03695
ZNF267 zinc finger protein 267 2.0305
NCBP3 nuclear cap binding subunit 3 2.0293
SAMD9 sterile alpha motif domain containing 9 2.02915
PUM3 pumilio RNA binding family member 3 2.02685
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 2.02625
SAV1 salvador family WW domain containing protein 1 2.01925
DCPH1 damage control phosphatase 1 2.01855
PALB2 partner and localizer of BRCA2 2.0171
CAMTA2 calmodulin binding transcription activator 2 2.01705
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.013
LOC122526780 uncharacterized LOC122526780 2.0122
TTC19 tetratricopeptide repeat domain 19 2.009
RNFT1-DT RNFT1 divergent transcript 2.00295

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.89494
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -6.34725
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -6.1517
PSRC1 proline/serine-rich coiled-coil 1 -5.1199
SCAND1 SCAN domain containing 1 -5.0843
RSU1 Ras suppressor protein 1 -4.97535
RAI14 retinoic acid induced 14 -4.93105
ZMIZ1 zinc finger, MIZ-type containing 1 -4.92255
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.91535
MNAT1 MNAT CDK-activating kinase assembly factor 1 -4.69635
CCNB2 cyclin B2 -4.4212
HLA-DMA major histocompatibility complex, class II, DM alpha -4.1571
CCNB1 cyclin B1 -4.08835
FGFR4 fibroblast growth factor receptor 4 -4.07333
NUCB2 nucleobindin 2 -4.0346
HSPB1 heat shock 27kDa protein 1 -3.637
MSRA methionine sulfoxide reductase A -3.4792
LOC124907782 dual specificity protein phosphatase 22 -3.40465
PLS1 plastin 1 -3.3488
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -3.33512
LGMN legumain -3.27745
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.21662
ILK integrin-linked kinase -3.19955
PCCB propionyl CoA carboxylase, beta polypeptide -3.1907
RHEB Ras homolog enriched in brain -3.17612
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.13425
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -3.13165
DERA deoxyribose-phosphate aldolase (putative) -3.08015
DPYD dihydropyrimidine dehydrogenase -3.06935
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.05125
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.03038
GLRX glutaredoxin (thioltransferase) -2.95108
LIMD2 LIM domain containing 2 -2.93445
SCARB1 scavenger receptor class B, member 1 -2.91105
ANO10 anoctamin 10 -2.86245
OXA1L oxidase (cytochrome c) assembly 1-like -2.83065
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.82265
ANXA7 annexin A7 -2.7986
MAPK13 mitogen-activated protein kinase 13 -2.79428
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.79272
ATF5 activating transcription factor 5 -2.77785
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -2.76885
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -2.75215
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.7375
ZNF274 zinc finger protein 274 -2.731
SLC35B1 solute carrier family 35, member B1 -2.69755
CBR1 carbonyl reductase 1 -2.68365
TRIM24 tripartite motif containing 24 -2.64227
ACTG1 actin gamma 1 -2.63037
PGAM4 phosphoglycerate mutase family member 4 -2.6168
RABL3 RAB, member of RAS oncogene family-like 3 -2.60625
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.6047
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.5903
SOX11 SRY (sex determining region Y)-box 11 -2.57583
RTL8C retrotransposon Gag like 8C -2.5743
TBCA tubulin folding cofactor A -2.53655
SCGB1D1 secretoglobin, family 1D, member 1 -2.53467
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.5318
ARB2A ARB2 cotranscriptional regulator A -2.5169
PCP4 Purkinje cell protein 4 -2.5116
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 -2.5084
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.5064
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -2.4959
NLRP2B NLR family pyrin domain containing 2B -2.48345
GPC5 glypican 5 -2.4776
ALDOC aldolase C, fructose-bisphosphate -2.4769
TCEAL4 transcription elongation factor A (SII)-like 4 -2.4716
SNX3 sorting nexin 3 -2.44488
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.43132
PDHB pyruvate dehydrogenase (lipoamide) beta -2.4254
RPL9 ribosomal protein L9 -2.39275
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.38692
RPS15 ribosomal protein S15 -2.3868
RHOBTB1 Rho-related BTB domain containing 1 -2.385
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -2.38329
BANF1 barrier to autointegration factor 1 -2.38205
ELP4 elongator acetyltransferase complex subunit 4 -2.3812
METTL9 methyltransferase like 9 -2.37145
NREP neuronal regeneration related protein -2.36052
RPL23A ribosomal protein L23a -2.36049
HMGN2 high mobility group nucleosomal binding domain 2 -2.35865
GLRX5 glutaredoxin 5 -2.3441
RPL41 ribosomal protein L41 -2.33495
A1CF APOBEC1 complementation factor -2.3306
PEG10 paternally expressed 10 -2.33037
MTREX Mtr4 exosome RNA helicase -2.32885
PGM1 phosphoglucomutase 1 -2.31995
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -2.30695
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.3034
TUBA1B tubulin, alpha 1b -2.3027
RPL34 ribosomal protein L34 -2.29865
H3-3A H3.3 histone A -2.29811
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.29675
CD5L CD5 molecule-like -2.2935
AKAP8 A kinase (PRKA) anchor protein 8 -2.28758
RPS10 ribosomal protein S10 -2.28448
FIG4 FIG4 phosphoinositide 5-phosphatase -2.27875
RPS13 ribosomal protein S13 -2.27805
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -2.2768
AGGF1 angiogenic factor with G patch and FHA domains 1 -2.27318
OCEL1 occludin/ELL domain containing 1 -2.2589
BLMH bleomycin hydrolase -2.2536
RPS4X ribosomal protein S4, X-linked -2.25003
RPS18 ribosomal protein S18 -2.2453
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -2.2429
DENND2D DENN/MADD domain containing 2D -2.23685
RPS24 ribosomal protein S24 -2.2368
ANGPT1 angiopoietin 1 -2.23665
TUBA1C tubulin, alpha 1c -2.23277
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.22095
SCG3 secretogranin III -2.21835
LNPEP leucyl/cystinyl aminopeptidase -2.2144
MAT2B methionine adenosyltransferase II, beta -2.2125
COBLL1 cordon-bleu WH2 repeat protein-like 1 -2.20836
IGF2 insulin-like growth factor 2 -2.2004
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.1938
ASGR1 asialoglycoprotein receptor 1 -2.18485
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.17765
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -2.17505
TLE5 TLE family member 5, transcriptional modulator -2.1731
RPS15A ribosomal protein S15a -2.15805
COX7C cytochrome c oxidase subunit VIIc -2.15555
PECR peroxisomal trans-2-enoyl-CoA reductase -2.14735
AKR1D1 aldo-keto reductase family 1, member D1 -2.1468
ITGA1 integrin, alpha 1 -2.14595
PARL presenilin associated, rhomboid-like -2.14475
RPL27A ribosomal protein L27a -2.1437
HNMT histamine N-methyltransferase -2.14288
COMMD10 COMM domain containing 10 -2.13735
GNG4 guanine nucleotide binding protein (G protein), gamma 4 -2.13455
ADAM10 ADAM metallopeptidase domain 10 -2.12825
RPS11 ribosomal protein S11 -2.1255
STAU2 staufen double-stranded RNA binding protein 2 -2.12525
ODAM odontogenic, ameloblast asssociated -2.12355
HIGD1B HIG1 hypoxia inducible domain family, member 1B -2.11585
FGF20 fibroblast growth factor 20 -2.11525
REPIN1 replication initiator 1 -2.10075
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -2.09885
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.0911
GAPDH glyceraldehyde-3-phosphate dehydrogenase -2.08969
TBX2 T-box 2 -2.08748
TIMP3 TIMP metallopeptidase inhibitor 3 -2.084
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -2.0811
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.07245
PDZRN3 PDZ domain containing ring finger 3 -2.06745
RPS23 ribosomal protein S23 -2.0665
C2CD5 C2 calcium-dependent domain containing 5 -2.06455
MORF4L2 mortality factor 4 like 2 -2.0552
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 -2.05145
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -2.0509
RGS7 regulator of G-protein signaling 7 -2.0495
LGALS14 lectin, galactoside-binding, soluble, 14 -2.0485
LECT2 leukocyte cell-derived chemotaxin 2 -2.04675
CAPZB capping protein (actin filament) muscle Z-line, beta -2.04132
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -2.0411
TRMT5 tRNA methyltransferase 5 -2.03755
ACTL6B actin-like 6B -2.03572
UGP2 UDP-glucose pyrophosphorylase 2 -2.03535
CXCL2 chemokine (C-X-C motif) ligand 2 -2.0348
RPL30 ribosomal protein L30 -2.03075
TUBA1A tubulin, alpha 1a -2.02356
SUSD4 sushi domain containing 4 -2.02145
TRIB3 tribbles pseudokinase 3 -2.019
OAZ1 ornithine decarboxylase antizyme 1 -2.01582
FCN3 ficolin (collagen/fibrinogen domain containing) 3 -2.0156
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -2.01392
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) -2.0126
HMGA2 high mobility group AT-hook 2 -2.0068
PTPRN protein tyrosine phosphatase, receptor type, N -2.00545
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.00345