CRCGN008_HEPG2_24H:O19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-hydroxyanthraquinone 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN008_HEPG2_24H:O19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 5.4401
RPL39L ribosomal protein L39-like 5.28735
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.84075
UBQLN2 ubiquilin 2 4.77945
NOTCH1 notch 1 4.7109
CCL2 chemokine (C-C motif) ligand 2 4.5928
PRR15L proline rich 15-like 4.51955
NMU neuromedin U 4.47825
HEBP1 heme binding protein 1 4.17175
SKIC8 SKI8 subunit of superkiller complex 4.01905
PLSCR1 phospholipid scramblase 1 3.52133
CHN1 chimerin 1 3.3906
CNPY3 canopy FGF signaling regulator 3 3.2268
ANO1 anoctamin 1, calcium activated chloride channel 3.0595
PIH1D1 PIH1 domain containing 1 3.05495
HSPA1A heat shock 70kDa protein 1A 3.03105
SSBP2 single-stranded DNA binding protein 2 2.78113
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.67655
SIRT3 sirtuin 3 2.58578
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.53763
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.44975
ZNF589 zinc finger protein 589 2.43462
DEFA6 defensin, alpha 6, Paneth cell-specific 2.4197
NOSIP nitric oxide synthase interacting protein 2.3468
DEFA5 defensin, alpha 5, Paneth cell-specific 2.3158
SSB Sjogren syndrome antigen B (autoantigen La) 2.18178
MTERF3 mitochondrial transcription termination factor 3 2.1159
TRMT61B tRNA methyltransferase 61B 2.11065
SMAD3 SMAD family member 3 2.10594
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.09355
ACVR1 activin A receptor, type I 2.06915
TMEM109 transmembrane protein 109 2.0561
PTK2 protein tyrosine kinase 2 2.03242
MRTFB myocardin related transcription factor B 2.016

decreased expression

Symbol Name Standardized Value
EGF epidermal growth factor -5.2721
PCCB propionyl CoA carboxylase, beta polypeptide -5.11805
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.9881
ACAA1 acetyl-CoA acyltransferase 1 -4.86913
DERA deoxyribose-phosphate aldolase (putative) -4.7569
HLA-DMA major histocompatibility complex, class II, DM alpha -4.7486
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.7462
LDHD lactate dehydrogenase D -4.4381
YME1L1 YME1-like 1 ATPase -4.37987
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.63358
FGFR4 fibroblast growth factor receptor 4 -3.58033
NGRN neugrin, neurite outgrowth associated -3.44235
FBXL12 F-box and leucine-rich repeat protein 12 -2.9028
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -2.86865
CCNB2 cyclin B2 -2.85485
UMOD uromodulin -2.826
SNX11 sorting nexin 11 -2.70557
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.69535
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.6931
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.6556
CD5L CD5 molecule-like -2.6356
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.56352
OXA1L oxidase (cytochrome c) assembly 1-like -2.535
DCXR dicarbonyl/L-xylulose reductase -2.5345
AKAP8 A kinase (PRKA) anchor protein 8 -2.48873
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 -2.4561
GLOD4 glyoxalase domain containing 4 -2.3828
CLCNKA chloride channel, voltage-sensitive Ka -2.3623
DNM2 dynamin 2 -2.3586
KNG1 kininogen 1 -2.31315
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.3043
DUSP9 dual specificity phosphatase 9 -2.1925
DDIT4 DNA-damage-inducible transcript 4 -2.1894
CLDN8 claudin 8 -2.18735
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.1352
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -2.13325
BHMT betaine--homocysteine S-methyltransferase -2.09735
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 -2.06965
CST7 cystatin F (leukocystatin) -2.06955
DPYS dihydropyrimidinase -2.05575
HSPA8 heat shock 70kDa protein 8 -2.04727
AZU1 azurocidin 1 -2.0194