CRCGN008_HEPG2_24H:O20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-hydroxyanthraquinone 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN008_HEPG2_24H:O20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 7.22545
CHN1 chimerin 1 6.8445
CYCS cytochrome c, somatic 5.88455
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.36725
ADRB2 adrenoceptor beta 2, surface 5.29645
CIAO3 cytosolic iron-sulfur assembly component 3 5.11755
MYLK myosin light chain kinase 4.98615
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.5713
SSBP2 single-stranded DNA binding protein 2 4.4635
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.3871
EPHB2 EPH receptor B2 4.24654
DYNLT3 dynein, light chain, Tctex-type 3 4.23695
CDPF1 cysteine-rich, DPF motif domain containing 1 4.161
PRR15L proline rich 15-like 3.99635
PEX11A peroxisomal biogenesis factor 11 alpha 3.9689
GPER1 G protein-coupled estrogen receptor 1 3.77303
TIAM1 T-cell lymphoma invasion and metastasis 1 3.29848
CDK19 cyclin-dependent kinase 19 3.29323
CNPY3 canopy FGF signaling regulator 3 3.2357
NMU neuromedin U 3.1407
PMM2 phosphomannomutase 2 3.07525
CDCA4 cell division cycle associated 4 3.03685
CCL2 chemokine (C-C motif) ligand 2 2.93665
EDN1 endothelin 1 2.9313
LMO3 LIM domain only 3 (rhombotin-like 2) 2.72075
GPR15 G protein-coupled receptor 15 2.66245
NOTCH1 notch 1 2.59325
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.589
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.4193
NKX2-1 NK2 homeobox 1 2.40198
ZNF589 zinc finger protein 589 2.40023
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.3154
SFTPB surfactant protein B 2.26113
IER3 immediate early response 3 2.25445
KRT81 keratin 81, type II 2.2286
CCP110 centriolar coiled coil protein 110kDa 2.18755
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.18705
TSHR thyroid stimulating hormone receptor 2.16935
TLR4 toll-like receptor 4 2.1647
SOCS2 suppressor of cytokine signaling 2 2.1586
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.11778
HMBOX1 homeobox containing 1 2.0715
FAAP24 FA core complex associated protein 24 2.05725
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.04985
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.0458

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -5.23935
TCERG1 transcription elongation regulator 1 -4.73885
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.9883
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.7565
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.31175
CCNB2 cyclin B2 -3.17385
OXA1L oxidase (cytochrome c) assembly 1-like -3.1188
FBXL12 F-box and leucine-rich repeat protein 12 -2.8898
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.88765
NKG7 natural killer cell granule protein 7 -2.7411
CHIC2 cysteine-rich hydrophobic domain 2 -2.595
DDIT4 DNA-damage-inducible transcript 4 -2.55705
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.52358
SLC35F2 solute carrier family 35, member F2 -2.50475
CLDN10 claudin 10 -2.3957
TXNDC9 thioredoxin domain containing 9 -2.28942
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.255
MAPK13 mitogen-activated protein kinase 13 -2.2147
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -2.1618
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.14852
TCTN1 tectonic family member 1 -2.1255
IDO1 indoleamine 2,3-dioxygenase 1 -2.11775
ZFTA zinc finger translocation associated -2.10885
GNLY granulysin -2.0994
AQP5 aquaporin 5 -2.08535
TTC38 tetratricopeptide repeat domain 38 -2.07705
ZNF134 zinc finger protein 134 -2.0528
ZW10 zw10 kinetochore protein -2.03145