CRCGN008_HEPG2_24H:O21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-hydroxyanthraquinone 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

143 genes differentially expressed following the CRCGN008_HEPG2_24H:O21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
PPARG peroxisome proliferator-activated receptor gamma 5.41175
MYLK myosin light chain kinase 5.23475
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.1481
CBR3 carbonyl reductase 3 4.79765
STK10 serine/threonine kinase 10 4.77595
SQOR sulfide quinone oxidoreductase 4.68935
HOOK2 hook microtubule-tethering protein 2 4.19012
CCL2 chemokine (C-C motif) ligand 2 4.0751
CEP57 centrosomal protein 57kDa 4.03166
MAP7 microtubule-associated protein 7 3.51522
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.46895
HEBP1 heme binding protein 1 3.3273
CYB561 cytochrome b561 2.95475
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.7909
VGLL4 vestigial-like family member 4 2.7106
NBAS neuroblastoma amplified sequence 2.57935
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.57015
CNPY3 canopy FGF signaling regulator 3 2.55275
TBP TATA box binding protein 2.53885
KIF20A kinesin family member 20A 2.52295
TBXAS1 thromboxane A synthase 1 (platelet) 2.51445
DND1 DND microRNA-mediated repression inhibitor 1 2.50553
CDK19 cyclin-dependent kinase 19 2.49037
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.4856
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 2.4768
JADE2 jade family PHD finger 2 2.4617
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 2.44615
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.415
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.38515
TPST1 tyrosylprotein sulfotransferase 1 2.33475
ACOD1 aconitate decarboxylase 1 2.28395
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.28157
IP6K2 inositol hexakisphosphate kinase 2 2.2788
GPATCH8 G patch domain containing 8 2.23703
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.21005
ASXL2 additional sex combs like transcriptional regulator 2 2.2012
CCP110 centriolar coiled coil protein 110kDa 2.1951
SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.1937
PLSCR1 phospholipid scramblase 1 2.17605
DPH2 DPH2 homolog (S. cerevisiae) 2.16275
PDZD8 PDZ domain containing 8 2.1351
MTCH1 mitochondrial carrier 1 2.1292
TMUB2 transmembrane and ubiquitin-like domain containing 2 2.1197
PIH1D1 PIH1 domain containing 1 2.10825
FERMT1 fermitin family member 1 2.08685
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 2.0751
FBLN2 fibulin 2 2.06365
THBS2 thrombospondin 2 2.04755
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 2.0377
SDC1 syndecan 1 2.03312
PCDHB13 protocadherin beta 13 2.0067
NME7 NME/NM23 family member 7 2.0038
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 2.00265

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
ILK integrin-linked kinase -5.66395
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.18145
GOLT1B golgi transport 1B -5.1319
VDAC1 voltage-dependent anion channel 1 -4.64197
CCNB1 cyclin B1 -4.51285
CCNB2 cyclin B2 -4.08695
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.00325
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.86375
GNAS GNAS complex locus -3.74079
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -3.3997
HMG20B high mobility group 20B -3.32555
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.2564
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.21012
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.1436
FBXO7 F-box protein 7 -3.00665
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.9376
CD320 CD320 molecule -2.72485
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E -2.7006
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.64855
SH3GLB2 SH3-domain GRB2-like endophilin B2 -2.6335
CLTB clathrin, light chain B -2.63174
CUL1 cullin 1 -2.62335
IL4R interleukin 4 receptor -2.6167
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.61357
CA14 carbonic anhydrase XIV -2.49735
ICOS inducible T-cell co-stimulator -2.4892
CHIC2 cysteine-rich hydrophobic domain 2 -2.4735
TRAT1 T cell receptor associated transmembrane adaptor 1 -2.4507
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -2.4224
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 -2.41435
NUP58 nucleoporin 58 -2.38855
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.3782
ZNF280D zinc finger protein 280D -2.37185
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled -2.3684
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.34385
PHEX phosphate regulating endopeptidase homolog, X-linked -2.3393
KLHL4 kelch-like family member 4 -2.33125
OXA1L oxidase (cytochrome c) assembly 1-like -2.3299
LINS1 lines homolog 1 -2.32945
ZNF287 zinc finger protein 287 -2.317
TMEM106B transmembrane protein 106B -2.31545
CXCL11 chemokine (C-X-C motif) ligand 11 -2.30305
RIC3 RIC3 acetylcholine receptor chaperone -2.29635
CCKBR cholecystokinin B receptor -2.28695
GALE UDP-galactose-4-epimerase -2.2546
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -2.24795
CUX2 cut-like homeobox 2 -2.24775
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -2.22975
CLEC2D C-type lectin domain family 2, member D -2.22265
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -2.22233
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) -2.2204
TOLLIP toll interacting protein -2.2054
PDE5A phosphodiesterase 5A, cGMP-specific -2.1911
BEAN1 brain expressed, associated with NEDD4, 1 -2.1896
PLAAT2 phospholipase A and acyltransferase 2 -2.1744
MINAR1 membrane integral NOTCH2 associated receptor 1 -2.1737
IL21 interleukin 21 -2.165
ZP2 zona pellucida glycoprotein 2 (sperm receptor) -2.1526
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 -2.1452
BTC betacellulin -2.14225
CDSN corneodesmosin -2.13867
RECQL RecQ helicase-like -2.13735
CDON cell adhesion associated, oncogene regulated -2.13455
CLPTM1 cleft lip and palate associated transmembrane protein 1 -2.12322
MYEF2 myelin expression factor 2 -2.12005
NEUROD4 neuronal differentiation 4 -2.11865
MAPK10 mitogen-activated protein kinase 10 -2.10945
TMEM14B transmembrane protein 14B -2.10645
DCAF13 DDB1 and CUL4 associated factor 13 -2.10355
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 -2.09395
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 -2.09235
LDB3 LIM domain binding 3 -2.08828
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) -2.08658
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -2.08625
PMFBP1 polyamine modulated factor 1 binding protein 1 -2.0848
TSPAN2 tetraspanin 2 -2.0799
LHX2 LIM homeobox 2 -2.0753
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.07285
USP53 ubiquitin specific peptidase 53 -2.0672
PEBP1 phosphatidylethanolamine binding protein 1 -2.06527
MBTPS2 membrane-bound transcription factor peptidase, site 2 -2.0594
ZBTB16 zinc finger and BTB domain containing 16 -2.0577
ATRNL1 attractin-like 1 -2.05753
NRIP1 nuclear receptor interacting protein 1 -2.04975
SLC30A4 solute carrier family 30 (zinc transporter), member 4 -2.03605
USP27X ubiquitin specific peptidase 27, X-linked -2.0332
SLC45A2 solute carrier family 45, member 2 -2.00735
RAI2 retinoic acid induced 2 -2.0028