CRCGN008_HEPG2_24H:O22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-hydroxyanthraquinone 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

90 genes differentially expressed following the CRCGN008_HEPG2_24H:O22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 7.58673
HOXA10 homeobox A10 5.55188
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.22155
CHMP6 charged multivesicular body protein 6 5.2083
MYLK myosin light chain kinase 5.1762
HLA-DMA major histocompatibility complex, class II, DM alpha 5.12765
C2CD2 C2 calcium-dependent domain containing 2 4.8559
SQOR sulfide quinone oxidoreductase 4.6582
EGF epidermal growth factor 4.58105
ABHD6 abhydrolase domain containing 6 4.3432
GSTZ1 glutathione S-transferase zeta 1 4.2442
GATA3 GATA binding protein 3 3.8335
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.74403
LPAR2 lysophosphatidic acid receptor 2 3.3096
MAP7 microtubule-associated protein 7 3.17882
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 3.1538
CYCS cytochrome c, somatic 3.12315
SLC75A1 solute carrier family 75 member 1 3.07325
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.93985
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.75958
JADE2 jade family PHD finger 2 2.73365
SSBP2 single-stranded DNA binding protein 2 2.64755
WDTC1 WD and tetratricopeptide repeats 1 2.64353
CRIPTO3 cripto, EGF-CFC family member 3 2.60165
LOC122526780 uncharacterized LOC122526780 2.56965
CORO1A coronin, actin binding protein, 1A 2.54495
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 2.4933
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.43185
TLR4 toll-like receptor 4 2.3907
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.34625
MYOT myotilin 2.34505
SYNM synemin, intermediate filament protein 2.3185
SPEG SPEG complex locus 2.2934
GAGE1 G antigen 1 2.27385
NOSIP nitric oxide synthase interacting protein 2.2513
CD40 CD40 molecule, TNF receptor superfamily member 5 2.24316
COL8A2 collagen, type VIII, alpha 2 2.23672
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.20552
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 2.17405
GPATCH8 G patch domain containing 8 2.13063
NUP153 nucleoporin 153kDa 2.12285
GPHN gephyrin 2.11455
PAQR5 progestin and adipoQ receptor family member V 2.1071
METTL25B methyltransferase like 25B 2.08425
FAM50B family with sequence similarity 50, member B 2.08355
LRRC2 leucine rich repeat containing 2 2.06645
CIAO3 cytosolic iron-sulfur assembly component 3 2.0639
SECTM1 secreted and transmembrane 1 2.0584
RAP1A RAP1A, member of RAS oncogene family 2.0557
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 2.0537
PHF13 PHD finger protein 13 2.0419
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) 2.03215

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -5.4951
ZNF586 zinc finger protein 586 -5.25015
ADI1 acireductone dioxygenase 1 -5.1514
NUP85 nucleoporin 85kDa -5.08485
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.0516
OXA1L oxidase (cytochrome c) assembly 1-like -4.95035
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.53485
CCDC86 coiled-coil domain containing 86 -4.46125
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.30635
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.1843
PCCB propionyl CoA carboxylase, beta polypeptide -4.05065
PRPF4 pre-mRNA processing factor 4 -3.85162
ARID5B AT rich interactive domain 5B (MRF1-like) -3.8429
JPT1 Jupiter microtubule associated homolog 1 -3.40395
MAPK13 mitogen-activated protein kinase 13 -3.39593
MRPS7 mitochondrial ribosomal protein S7 -3.29595
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.11312
ICAM3 intercellular adhesion molecule 3 -3.02305
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.01638
CCNB2 cyclin B2 -2.92675
ZMIZ1 zinc finger, MIZ-type containing 1 -2.76075
MRPL58 mitochondrial ribosomal protein L58 -2.65545
KCTD2 potassium channel tetramerization domain containing 2 -2.52213
WASHC4 WASH complex subunit 4 -2.50328
RNF167 ring finger protein 167 -2.48775
FBXL12 F-box and leucine-rich repeat protein 12 -2.42245
DDIT4 DNA-damage-inducible transcript 4 -2.37575
GRB2 growth factor receptor-bound protein 2 -2.33175
NRIP1 nuclear receptor interacting protein 1 -2.30402
HSPA8 heat shock 70kDa protein 8 -2.24457
CDR2L cerebellar degeneration-related protein 2-like -2.2436
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.18922
ATP5PD ATP synthase peripheral stalk subunit d -2.1427
SAP30BP SAP30 binding protein -2.14115
EIF4A3 eukaryotic translation initiation factor 4A3 -2.11465
FHL2 four and a half LIM domains 2 -2.10395
ASRGL1 asparaginase like 1 -2.07225
SPOUT1 SPOUT domain containing methyltransferase 1 -2.04665