CRCGN008_HEPG2_24H:O23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-hydroxyanthraquinone 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN008_HEPG2_24H:O23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EGF epidermal growth factor 5.00905
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.87615
EPHB2 EPH receptor B2 4.79862
CHMP6 charged multivesicular body protein 6 4.7339
ADRB2 adrenoceptor beta 2, surface 4.6921
NMU neuromedin U 4.5098
EPHA3 EPH receptor A3 4.44803
GPER1 G protein-coupled estrogen receptor 1 3.71102
PFKL phosphofructokinase, liver 3.65232
ZFP36 ZFP36 ring finger protein 3.485
CCL2 chemokine (C-C motif) ligand 2 3.3188
HEBP1 heme binding protein 1 3.26575
CHN1 chimerin 1 3.1684
CNPY3 canopy FGF signaling regulator 3 3.1439
TIAM1 T-cell lymphoma invasion and metastasis 1 3.08215
BPHL biphenyl hydrolase-like (serine hydrolase) 3.034
HLA-DRA major histocompatibility complex, class II, DR alpha 2.96125
JADE2 jade family PHD finger 2 2.83225
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.7981
SSBP2 single-stranded DNA binding protein 2 2.75188
TBXA2R thromboxane A2 receptor 2.68523
FOS FBJ murine osteosarcoma viral oncogene homolog 2.5888
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.55867
TBP TATA box binding protein 2.49785
RAB31 RAB31, member RAS oncogene family 2.46908
SMYD5 SMYD family member 5 2.467
GADD45A growth arrest and DNA-damage-inducible, alpha 2.4269
CSK c-src tyrosine kinase 2.4212
ZNF589 zinc finger protein 589 2.37327
CLEC5A C-type lectin domain family 5, member A 2.33425
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 2.2726
ADGRL4 adhesion G protein-coupled receptor L4 2.26175
LCN2 lipocalin 2 2.2443
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.21
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 2.18565
CRYZL1 crystallin, zeta (quinone reductase)-like 1 2.17595
DEFA6 defensin, alpha 6, Paneth cell-specific 2.17295
NOSIP nitric oxide synthase interacting protein 2.1398
DEFA5 defensin, alpha 5, Paneth cell-specific 2.12365
RORB RAR-related orphan receptor B 2.12125
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.11193
TLR4 toll-like receptor 4 2.0869
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.06495
FABP1 fatty acid binding protein 1, liver 2.0616
MORC3 MORC family CW-type zinc finger 3 2.0547
RNPS1 RNA binding protein S1, serine-rich domain 2.01965
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.01395
RBMY1J RNA binding motif protein, Y-linked, family 1, member J 2.01375
CDO1 cysteine dioxygenase type 1 2.0034

decreased expression

Symbol Name Standardized Value
HLA-DMA major histocompatibility complex, class II, DM alpha -5.13345
CHMP4B charged multivesicular body protein 4B -5.11378
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -5.02863
NUP85 nucleoporin 85kDa -4.9574
CCNB2 cyclin B2 -4.7944
ENOPH1 enolase-phosphatase 1 -4.71875
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.00265
CCNB1 cyclin B1 -3.7502
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.3095
HMG20B high mobility group 20B -3.23857
OXA1L oxidase (cytochrome c) assembly 1-like -2.9235
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.88
MRPS7 mitochondrial ribosomal protein S7 -2.6639
NRIP1 nuclear receptor interacting protein 1 -2.64587
MRPL58 mitochondrial ribosomal protein L58 -2.6339
S100A1 S100 calcium binding protein A1 -2.633
TXNDC9 thioredoxin domain containing 9 -2.44933
WBP2 WW domain binding protein 2 -2.4044
REC8 REC8 meiotic recombination protein -2.25165
SAP30BP SAP30 binding protein -2.2357
CTSW cathepsin W -2.1798
MALT1 MALT1 paracaspase -2.1174
RBM34 RNA binding motif protein 34 -2.04765
DDIT4 DNA-damage-inducible transcript 4 -2.04655
GALNS galactosamine (N-acetyl)-6-sulfatase -2.0286
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.01785
LBHD1 LBH domain containing 1 -2.0103
KCTD2 potassium channel tetramerization domain containing 2 -2.00825