CRCGN008_HEPG2_24H:P04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tricresyl phosphate 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN008_HEPG2_24H:P04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 5.7079
PPARG peroxisome proliferator-activated receptor gamma 5.149
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.1116
SSBP2 single-stranded DNA binding protein 2 4.0021
VAV3 vav 3 guanine nucleotide exchange factor 3.99522
SNAP25 synaptosomal-associated protein, 25kDa 3.97515
HLA-DRA major histocompatibility complex, class II, DR alpha 3.95038
MINDY1 MINDY lysine 48 deubiquitinase 1 3.6562
MICALL1 MICAL-like 1 3.56425
CCDC85B coiled-coil domain containing 85B 3.549
FOS FBJ murine osteosarcoma viral oncogene homolog 3.27695
CDK19 cyclin-dependent kinase 19 3.23325
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.20945
MAP7 microtubule-associated protein 7 3.18928
GATA2 GATA binding protein 2 3.13877
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.04225
KDM5A lysine (K)-specific demethylase 5A 3.0256
INTS13 integrator complex subunit 13 2.75765
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.66232
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.52545
NFIL3 nuclear factor, interleukin 3 regulated 2.50535
JADE2 jade family PHD finger 2 2.43027
UBE2S ubiquitin-conjugating enzyme E2S 2.3873
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.29295
NPR2 natriuretic peptide receptor 2 2.213
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 2.1129
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.0849
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.0849
CORO1C coronin, actin binding protein, 1C 2.04435
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.04125
PER1 period circadian clock 1 2.03825

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
TARBP1 TAR (HIV-1) RNA binding protein 1 -8.38535
TLCD3A TLC domain containing 3A -4.9662
NRIP1 nuclear receptor interacting protein 1 -4.93507
LOC124907782 dual specificity protein phosphatase 22 -4.7922
SMNDC1 survival motor neuron domain containing 1 -4.7709
LDHD lactate dehydrogenase D -4.5919
CCNB2 cyclin B2 -4.551
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.25395
RFC2 replication factor C (activator 1) 2, 40kDa -4.00297
GNAS GNAS complex locus -3.54274
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.4533
SPAG4 sperm associated antigen 4 -3.18395
OXA1L oxidase (cytochrome c) assembly 1-like -3.09965
SOAT2 sterol O-acyltransferase 2 -2.6546
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.5947
ANKRD10 ankyrin repeat domain 10 -2.3507
BMP4 bone morphogenetic protein 4 -2.326
SQOR sulfide quinone oxidoreductase -2.3186
DCK deoxycytidine kinase -2.22835
COL5A2 collagen, type V, alpha 2 -2.22342
THNSL2 threonine synthase-like 2 (S. cerevisiae) -2.2131
ANXA3 annexin A3 -2.16975
PLK2 polo-like kinase 2 -2.16785
NINJ1 ninjurin 1 -2.0254