CRCGN008_HEPG2_24H:P05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tricresyl phosphate 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

328 genes differentially expressed following the CRCGN008_HEPG2_24H:P05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 10.0
CHN1 chimerin 1 5.51085
MINDY1 MINDY lysine 48 deubiquitinase 1 5.3257
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 5.0925
GSTZ1 glutathione S-transferase zeta 1 4.56415
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 4.48655
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.47585
E2F2 E2F transcription factor 2 4.4707
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.4575
MOK MOK protein kinase 4.4332
LCN2 lipocalin 2 4.33795
UBQLN2 ubiquilin 2 4.16165
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.8309
EPN2 epsin 2 3.779
NT5DC2 5'-nucleotidase domain containing 2 3.72235
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.43645
PRR15L proline rich 15-like 3.4253
MAP7 microtubule-associated protein 7 3.40725
RRAGA Ras-related GTP binding A 3.3638
KIF20A kinesin family member 20A 3.3043
HMG20B high mobility group 20B 3.29422
CDC34 cell division cycle 34 3.28415
NNT nicotinamide nucleotide transhydrogenase 3.27848
EGF epidermal growth factor 3.2746
ARFIP2 ADP-ribosylation factor interacting protein 2 3.25225
USP6 ubiquitin specific peptidase 6 3.2233
POLR1A polymerase (RNA) I polypeptide A, 194kDa 3.21582
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 3.19925
SQOR sulfide quinone oxidoreductase 3.1959
AMDHD2 amidohydrolase domain containing 2 3.1568
PLSCR1 phospholipid scramblase 1 3.13287
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.12635
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 3.0919
SFTPB surfactant protein B 3.08802
FOXO3 forkhead box O3 3.07621
DROSHA drosha, ribonuclease type III 3.0708
CCDC86 coiled-coil domain containing 86 3.0303
MSRA methionine sulfoxide reductase A 3.0024
TRAPPC3 trafficking protein particle complex 3 2.8942
PLS1 plastin 1 2.8573
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.82727
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.80775
SCARB1 scavenger receptor class B, member 1 2.7418
JADE2 jade family PHD finger 2 2.7379
USP6NL USP6 N-terminal like 2.70215
BLCAP bladder cancer associated protein 2.6404
MCOLN1 mucolipin 1 2.6315
WASF3 WAS protein family, member 3 2.62015
RNF123 ring finger protein 123 2.61805
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.6049
MAPK9 mitogen-activated protein kinase 9 2.59898
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.5988
CDK6 cyclin-dependent kinase 6 2.59755
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 2.59315
PYCR1 pyrroline-5-carboxylate reductase 1 2.5896
HSPB3 heat shock 27kDa protein 3 2.57095
EVL Enah/Vasp-like 2.566
TIAM1 T-cell lymphoma invasion and metastasis 1 2.5489
KDM7A lysine (K)-specific demethylase 7A 2.5488
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.546
KLHDC2 kelch domain containing 2 2.5396
NFIL3 nuclear factor, interleukin 3 regulated 2.5378
PNKP polynucleotide kinase 3'-phosphatase 2.5144
LRRC59 leucine rich repeat containing 59 2.51195
MRPS2 mitochondrial ribosomal protein S2 2.5072
NLRP2B NLR family pyrin domain containing 2B 2.4973
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.48415
PNPLA6 patatin-like phospholipase domain containing 6 2.47205
CASC3 cancer susceptibility candidate 3 2.464
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.45775
ZNF692 zinc finger protein 692 2.45675
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.45385
COBL cordon-bleu WH2 repeat protein 2.4307
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.43015
MYOD1 myogenic differentiation 1 2.4244
NOSIP nitric oxide synthase interacting protein 2.41925
RPAP1 RNA polymerase II associated protein 1 2.41705
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.4074
ZDHHC11B zinc finger, DHHC-type containing 11B 2.4026
NOP10 NOP10 ribonucleoprotein 2.3957
ZDHHC6 zinc finger, DHHC-type containing 6 2.38915
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 2.38505
FNDC3B fibronectin type III domain containing 3B 2.3772
DHPS deoxyhypusine synthase 2.35595
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.34705
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.34634
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 2.32233
CYTH3 cytohesin 3 2.3128
DTX2 deltex 2, E3 ubiquitin ligase 2.3069
PGM1 phosphoglucomutase 1 2.3003
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.2837
KLHL41 kelch-like family member 41 2.2748
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.2732
PDCD6 programmed cell death 6 2.2732
PRKCD protein kinase C, delta 2.27195
TMPRSS11E transmembrane protease, serine 11E 2.27015
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.26825
PCDHB11 protocadherin beta 11 2.25207
DUSP14 dual specificity phosphatase 14 2.24715
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.2426
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 2.24145
UBAP2 ubiquitin associated protein 2 2.23438
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.22685
NISCH nischarin 2.225
HEATR6 HEAT repeat containing 6 2.213
CORO1A coronin, actin binding protein, 1A 2.21195
NUCB2 nucleobindin 2 2.20965
CLDN4 claudin 4 2.20085
CREB1 cAMP responsive element binding protein 1 2.1999
MLEC malectin 2.18603
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.184
TLCD3A TLC domain containing 3A 2.1823
ZFYVE26 zinc finger, FYVE domain containing 26 2.18005
ZNF589 zinc finger protein 589 2.17398
HELZ helicase with zinc finger 2.1649
RALGDS ral guanine nucleotide dissociation stimulator 2.15412
NBPF3 neuroblastoma breakpoint family, member 3 2.14885
COG2 component of oligomeric golgi complex 2 2.1476
LOC102724428 serine/threonine-protein kinase SIK1 2.14615
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 2.14583
FCHO1 FCH domain only 1 2.14215
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.14025
LOC122526780 uncharacterized LOC122526780 2.13445
GTF2A2 general transcription factor IIA, 2, 12kDa 2.1229
TRIM25 tripartite motif containing 25 2.1198
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.1182
PSG2 pregnancy specific beta-1-glycoprotein 2 2.11145
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 2.11142
PTCD1 pentatricopeptide repeat domain 1 2.11135
RAB15 RAB15, member RAS oncogene family 2.10572
BIRC2 baculoviral IAP repeat containing 2 2.1056
RAD51C RAD51 paralog C 2.10405
TMPRSS11D transmembrane protease, serine 11D 2.10325
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.10231
SSNA1 Sjogren syndrome nuclear autoantigen 1 2.0914
CHURC1-FNTB CHURC1-FNTB readthrough 2.09123
SPG11 spastic paraplegia 11 (autosomal recessive) 2.086
ATP13A1 ATPase type 13A1 2.0842
EML3 echinoderm microtubule associated protein like 3 2.08205
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 2.08015
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.07725
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase 2.07417
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.07385
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.0718
CGB8 chorionic gonadotropin, beta polypeptide 8 2.071
TSPAN6 tetraspanin 6 2.07055
DVL1 dishevelled segment polarity protein 1 2.06655
VCP valosin containing protein 2.06525
MARK3 MAP/microtubule affinity-regulating kinase 3 2.0628
MARCO macrophage receptor with collagenous structure 2.06055
SLC12A9 solute carrier family 12, member 9 2.05955
GSTA4 glutathione S-transferase alpha 4 2.05805
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.0574
SETD5 SET domain containing 5 2.05535
CPAP centrosome assembly and centriole elongation protein 2.04805
HOXA11 homeobox A11 2.046
GSAP gamma-secretase activating protein 2.0455
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 2.0412
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.0406
UBE3C ubiquitin protein ligase E3C 2.04055
TMEM187 transmembrane protein 187 2.04
FOXA2 forkhead box A2 2.03483
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.0323
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.03175
CHERP calcium homeostasis endoplasmic reticulum protein 2.0308
FAM193B family with sequence similarity 193, member B 2.03055
P4HB prolyl 4-hydroxylase, beta polypeptide 2.02942
PHKB phosphorylase kinase, beta 2.02543
MTMR1 myotubularin related protein 1 2.01101
CAPNS1 calpain, small subunit 1 2.0056
DAAM1 dishevelled associated activator of morphogenesis 1 2.0046
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 2.00195

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
SLC35F2 solute carrier family 35, member F2 -6.76145
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.58545
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.186
SMNDC1 survival motor neuron domain containing 1 -5.75825
ZW10 zw10 kinetochore protein -5.61935
CDC20 cell division cycle 20 -5.318
CCNH cyclin H -4.9543
ZNF586 zinc finger protein 586 -4.8917
MAPK13 mitogen-activated protein kinase 13 -4.75873
USP22 ubiquitin specific peptidase 22 -4.75462
ACAA1 acetyl-CoA acyltransferase 1 -4.46208
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -4.22235
NGRN neugrin, neurite outgrowth associated -4.2212
ZMIZ1 zinc finger, MIZ-type containing 1 -4.19755
ENOPH1 enolase-phosphatase 1 -4.0331
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.9889
HAT1 histone acetyltransferase 1 -3.96025
SCAND1 SCAN domain containing 1 -3.8655
FAIM Fas apoptotic inhibitory molecule -3.7582
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.66895
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -3.652
NUP93 nucleoporin 93kDa -3.6485
HSPA1A heat shock 70kDa protein 1A -3.51335
CRYZ crystallin, zeta (quinone reductase) -3.4972
PRCP prolylcarboxypeptidase (angiotensinase C) -3.44615
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.42655
THAP11 THAP domain containing 11 -3.42225
EAPP E2F-associated phosphoprotein -3.4121
KIFBP kinesin family binding protein -3.3622
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.35245
TBPL1 TBP-like 1 -3.3472
HYOU1 hypoxia up-regulated 1 -3.22585
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -3.2209
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.19032
EBNA1BP2 EBNA1 binding protein 2 -3.152
DACT1 dishevelled-binding antagonist of beta-catenin 1 -3.09765
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.049
RAB21 RAB21, member RAS oncogene family -3.03415
DYNLT3 dynein, light chain, Tctex-type 3 -3.0248
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -3.01045
DDIT4 DNA-damage-inducible transcript 4 -2.96175
OXA1L oxidase (cytochrome c) assembly 1-like -2.9273
GLOD4 glyoxalase domain containing 4 -2.9242
SMIM40 small integral membrane protein 40 -2.8321
PLK1 polo-like kinase 1 -2.7896
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.78485
MTFR1 mitochondrial fission regulator 1 -2.78263
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.7719
NAP1L3 nucleosome assembly protein 1-like 3 -2.75425
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.72825
RGS2 regulator of G-protein signaling 2 -2.72275
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -2.70885
ARCN1 archain 1 -2.6889
CLEC2D C-type lectin domain family 2, member D -2.668
PRR13 proline rich 13 -2.66285
TM9SF2 transmembrane 9 superfamily member 2 -2.6346
ADI1 acireductone dioxygenase 1 -2.62925
PTBP2 polypyrimidine tract binding protein 2 -2.6042
MAP2K5 mitogen-activated protein kinase kinase 5 -2.59565
ZFAND1 zinc finger, AN1-type domain 1 -2.5941
MRPL15 mitochondrial ribosomal protein L15 -2.5939
IFT52 intraflagellar transport 52 -2.59005
SFRP4 secreted frizzled-related protein 4 -2.58735
PCNP PEST proteolytic signal containing nuclear protein -2.58245
ANXA7 annexin A7 -2.55345
TCEAL4 transcription elongation factor A (SII)-like 4 -2.55105
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.53165
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -2.52365
CCN5 cellular communication network factor 5 -2.516
GFUS GDP-L-fucose synthase -2.50425
CAB39 calcium binding protein 39 -2.49265
VTN vitronectin -2.47625
ITGB1BP1 integrin beta 1 binding protein 1 -2.4724
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.4662
WDR43 WD repeat domain 43 -2.4496
LOC112694756 uncharaterized LOC112694756 -2.44385
TOMM34 translocase of outer mitochondrial membrane 34 -2.4414
NUDC nudC nuclear distribution protein -2.42712
FGG fibrinogen gamma chain -2.4028
CTSD cathepsin D -2.39935
AATF apoptosis antagonizing transcription factor -2.39145
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.38767
ELAC2 elaC ribonuclease Z 2 -2.38425
GPX7 glutathione peroxidase 7 -2.3832
USB1 U6 snRNA biogenesis 1 -2.38075
DSG2 desmoglein 2 -2.378
SOAT2 sterol O-acyltransferase 2 -2.37335
CYRIA CYFIP related Rac1 interactor A -2.37115
CXCL12 chemokine (C-X-C motif) ligand 12 -2.34683
NKAPD1 NKAP domain containing 1 -2.3468
DOK5 docking protein 5 -2.33085
VAT1 vesicle amine transport 1 -2.328
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -2.31915
BGN biglycan -2.29097
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.27715
THY1 Thy-1 cell surface antigen -2.27567
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 -2.27463
LBP lipopolysaccharide binding protein -2.27117
GOLT1B golgi transport 1B -2.2707
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.26397
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -2.2615
THBS2 thrombospondin 2 -2.2488
NAE1 NEDD8 activating enzyme E1 subunit 1 -2.2441
TLR4 toll-like receptor 4 -2.24315
FGB fibrinogen beta chain -2.24043
BCAS2 breast carcinoma amplified sequence 2 -2.2112
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.2084
PTDSS1 phosphatidylserine synthase 1 -2.203
SCG2 secretogranin II -2.19755
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -2.18725
PEX2 peroxisomal biogenesis factor 2 -2.18415
EI24 etoposide induced 2.4 -2.1833
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -2.16628
IFRD2 interferon-related developmental regulator 2 -2.164
CTSO cathepsin O -2.16395
UPP1 uridine phosphorylase 1 -2.1556
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.1552
CLU clusterin -2.14868
CPQ carboxypeptidase Q -2.1464
TCN2 transcobalamin II -2.1452
TMT1A thiol methyltransferase 1A -2.14313
MMRN2 multimerin 2 -2.1384
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.1331
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.13005
DLAT dihydrolipoamide S-acetyltransferase -2.12265
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -2.11995
ZNF226 zinc finger protein 226 -2.11935
TRAIP TRAF interacting protein -2.11365
FGA fibrinogen alpha chain -2.1128
RECK reversion-inducing-cysteine-rich protein with kazal motifs -2.10825
CEP15 centrosomal protein 15 -2.10315
AGO1 argonaute RISC catalytic component 1 -2.09455
S1PR1 sphingosine-1-phosphate receptor 1 -2.09455
PPP1R16B protein phosphatase 1, regulatory subunit 16B -2.08598
AGMAT agmatine ureohydrolase (agmatinase) -2.0832
BAHCC1 BAH domain and coiled-coil containing 1 -2.07985
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.0661
APOH apolipoprotein H (beta-2-glycoprotein I) -2.064
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -2.06122
ZNF544 zinc finger protein 544 -2.0576
CHMP4B charged multivesicular body protein 4B -2.05615
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.0529
NPY1R neuropeptide Y receptor Y1 -2.05055
RCOR3 REST corepressor 3 -2.04825
RBM34 RNA binding motif protein 34 -2.04382
LOC128125814 uncharacterized LOC128125814 -2.04075
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -2.03905
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.0353
COL8A2 collagen, type VIII, alpha 2 -2.03428
THSD7A thrombospondin, type I, domain containing 7A -2.02042
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.01225
TXNDC9 thioredoxin domain containing 9 -2.0083
MALT1 MALT1 paracaspase -2.00792
MRPL39 mitochondrial ribosomal protein L39 -2.0023
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -2.0001