CRCGN008_HEPG2_24H:P07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K63993117 40.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

104 genes differentially expressed following the CRCGN008_HEPG2_24H:P07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 5.21295
INTS3 integrator complex subunit 3 5.05715
PPARG peroxisome proliferator-activated receptor gamma 5.0209
GSTZ1 glutathione S-transferase zeta 1 4.71475
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.7096
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.46395
SNAP25 synaptosomal-associated protein, 25kDa 4.45808
PRR15L proline rich 15-like 4.2833
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.92067
SSBP2 single-stranded DNA binding protein 2 3.91162
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.6737
HLA-DRA major histocompatibility complex, class II, DR alpha 3.56588
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.38545
UGDH UDP-glucose 6-dehydrogenase 2.8552
CCNF cyclin F 2.8392
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.77465
GPATCH8 G patch domain containing 8 2.76095
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 2.63978
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.62695
KIF20A kinesin family member 20A 2.6186
SERTAD3 SERTA domain containing 3 2.4759
LCN2 lipocalin 2 2.4555
OMG oligodendrocyte myelin glycoprotein 2.4523
FAIM Fas apoptotic inhibitory molecule 2.4505
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.4107
KLHL9 kelch-like family member 9 2.40362
LPAR2 lysophosphatidic acid receptor 2 2.3876
MX2 MX dynamin-like GTPase 2 2.3224
PSAT1 phosphoserine aminotransferase 1 2.31125
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.2946
RGS7 regulator of G-protein signaling 7 2.29325
RSAD2 radical S-adenosyl methionine domain containing 2 2.2778
CDPF1 cysteine-rich, DPF motif domain containing 1 2.21575
CXCL14 chemokine (C-X-C motif) ligand 14 2.20185
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.18775
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.18512
CARTPT CART prepropeptide 2.16385
WASF3 WAS protein family, member 3 2.15395
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.1305
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.08125
ARID4B AT rich interactive domain 4B (RBP1-like) 2.07605
SLC38A10 solute carrier family 38, member 10 2.0746
GCLM glutamate-cysteine ligase, modifier subunit 2.06835
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.05075
RCL1 RNA terminal phosphate cyclase-like 1 2.05065
MARK3 MAP/microtubule affinity-regulating kinase 3 2.05025
FNDC3B fibronectin type III domain containing 3B 2.0153

decreased expression

Symbol Name Standardized Value
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -7.78865
OXA1L oxidase (cytochrome c) assembly 1-like -6.24845
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.33695
KDM3A lysine (K)-specific demethylase 3A -5.1715
ZNF586 zinc finger protein 586 -5.0367
CCNB2 cyclin B2 -4.9883
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.92435
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.92415
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -4.73563
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.66275
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.60425
PCNA proliferating cell nuclear antigen -4.50795
HLA-DMA major histocompatibility complex, class II, DM alpha -4.0936
RNF167 ring finger protein 167 -3.36575
EDN1 endothelin 1 -3.00275
TCEAL4 transcription elongation factor A (SII)-like 4 -2.81975
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.81384
S100A4 S100 calcium binding protein A4 -2.7573
DSG2 desmoglein 2 -2.74175
ZW10 zw10 kinetochore protein -2.67915
SLC35F6 solute carrier family 35, member F6 -2.53015
MSMO1 methylsterol monooxygenase 1 -2.474
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 -2.4607
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.46
ZNF692 zinc finger protein 692 -2.4357
ZNF331 zinc finger protein 331 -2.3977
HSPA8 heat shock 70kDa protein 8 -2.39502
UFD1 ubiquitin recognition factor in ER associated degradation 1 -2.33655
ATRAID all-trans retinoic acid-induced differentiation factor -2.3245
SNED1 sushi, nidogen and EGF-like domains 1 -2.30443
NUP155 nucleoporin 155kDa -2.3018
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -2.29342
GFUS GDP-L-fucose synthase -2.29243
GLOD4 glyoxalase domain containing 4 -2.2742
DZIP1 DAZ interacting zinc finger protein 1 -2.2221
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.21715
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -2.2104
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.18825
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit -2.1678
LGALSL lectin, galactoside-binding-like -2.1667
STEAP1B STEAP family member 1B -2.15535
AUP1 ancient ubiquitous protein 1 -2.14105
SLC46A3 solute carrier family 46, member 3 -2.121
ACAA1 acetyl-CoA acyltransferase 1 -2.10235
SQLE squalene epoxidase -2.0869
SPACA9 sperm acrosome associated 9 -2.075
SGCE sarcoglycan, epsilon -2.06105
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.04195
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.03915
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.0364
KLHL25 kelch-like family member 25 -2.02895
CSNK2B casein kinase 2, beta polypeptide -2.0247
GABARAP GABA(A) receptor-associated protein -2.01645
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -2.01393
PNPLA3 patatin-like phospholipase domain containing 3 -2.0128
GRB10 growth factor receptor-bound protein 10 -2.00565
GMPS guanine monphosphate synthase -2.0045