CRCGN008_HEPG2_24H:P09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K63993117 10.15 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

84 genes differentially expressed following the CRCGN008_HEPG2_24H:P09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MCM3 minichromosome maintenance complex component 3 4.82885
NOSIP nitric oxide synthase interacting protein 4.76605
CBR3 carbonyl reductase 3 4.6713
STK10 serine/threonine kinase 10 4.36182
ADRB2 adrenoceptor beta 2, surface 4.3473
PPARG peroxisome proliferator-activated receptor gamma 4.30595
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.2041
WDR7 WD repeat domain 7 3.60435
GPER1 G protein-coupled estrogen receptor 1 3.55715
DMTF1 cyclin D binding myb-like transcription factor 1 3.27517
EGF epidermal growth factor 3.20665
SCARB1 scavenger receptor class B, member 1 3.19383
VGLL4 vestigial-like family member 4 3.18088
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 3.15975
NT5DC2 5'-nucleotidase domain containing 2 3.13815
NUCB2 nucleobindin 2 3.0029
JADE2 jade family PHD finger 2 2.9646
MTERF3 mitochondrial transcription termination factor 3 2.8632
SFTPB surfactant protein B 2.86063
LRP10 low density lipoprotein receptor-related protein 10 2.76365
ECD ecdysoneless homolog (Drosophila) 2.7345
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.54705
ICE1 interactor of little elongation complex ELL subunit 1 2.5311
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.5122
CCDC86 coiled-coil domain containing 86 2.40005
ALDOC aldolase C, fructose-bisphosphate 2.36275
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.3448
MRPS2 mitochondrial ribosomal protein S2 2.31275
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.29295
BIRC2 baculoviral IAP repeat containing 2 2.21755
MOSPD3 motile sperm domain containing 3 2.19215
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2.18235
ADAM10 ADAM metallopeptidase domain 10 2.17113
RAB31 RAB31, member RAS oncogene family 2.15523
RALGDS ral guanine nucleotide dissociation stimulator 2.14912
AP5M1 adaptor-related protein complex 5, mu 1 subunit 2.149
SOCS2 suppressor of cytokine signaling 2 2.14645
LOC124907782 dual specificity protein phosphatase 22 2.13555
ZDHHC6 zinc finger, DHHC-type containing 6 2.13545
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 2.12625
LRP5 low density lipoprotein receptor-related protein 5 2.11855
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.0938
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.0892
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.08195
ARFIP2 ADP-ribosylation factor interacting protein 2 2.0702
GOLGA8F golgin A8 family, member F 2.04875
TBC1D4 TBC1 domain family, member 4 2.04632
SORBS3 sorbin and SH3 domain containing 3 2.02238
SREBF1 sterol regulatory element binding transcription factor 1 2.0192
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.0124
H2AZ2 H2A.Z variant histone 2 2.00175

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -8.92015
CDC20 cell division cycle 20 -5.67995
TUBB6 tubulin, beta 6 class V -4.74795
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.66935
CCNB2 cyclin B2 -4.64095
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -4.41315
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.2868
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.2689
FAIM Fas apoptotic inhibitory molecule -2.74845
TCEAL4 transcription elongation factor A (SII)-like 4 -2.6392
CRYZ crystallin, zeta (quinone reductase) -2.63735
SCAND1 SCAN domain containing 1 -2.61135
ZIM3 zinc finger, imprinted 3 -2.58605
CLIC4 chloride intracellular channel 4 -2.55883
EAPP E2F-associated phosphoprotein -2.55775
ACAA1 acetyl-CoA acyltransferase 1 -2.51975
ATF5 activating transcription factor 5 -2.46598
ZNF93 zinc finger protein 93 -2.42292
BCAS2 breast carcinoma amplified sequence 2 -2.3547
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.34845
TOMM34 translocase of outer mitochondrial membrane 34 -2.3327
PRPF4 pre-mRNA processing factor 4 -2.26755
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.2133
SPAG4 sperm associated antigen 4 -2.20255
GDF3 growth differentiation factor 3 -2.19845
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) -2.09927
TOR1A torsin family 1, member A (torsin A) -2.0955
ITGB1BP1 integrin beta 1 binding protein 1 -2.0772
HSPA1A heat shock 70kDa protein 1A -2.0673
AMH anti-Mullerian hormone -2.06225
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 -2.0488
TREH trehalase (brush-border membrane glycoprotein) -2.0145
FBXL12 F-box and leucine-rich repeat protein 12 -2.0141